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Study · In vitro (cells) · 2008

7 results

Thymosin beta4 is cytoprotective in human gingival fibroblasts.

Reti R, Kwon E, Qiu P, Wheater M, Sosne G

European journal of oral sciences1 Oct 2008Cited by 31 (Europe PMC)

PMID18821984 (opens in a new tab)DOI10.1111/j.1600-0722.2008.00569.x (opens in a new tab)PepBankPUB-18821984
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In cultured human gingival fibroblasts, thymosin beta‑4 significantly suppressed interleukin-8 secretion after TNF-alpha stimulation.

    In plain wordsIn cells from human gums, thymosin beta‑4 lowered the release of the inflammatory signal IL-8 after TNF-alpha stimulation.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseIL-8 secretion after TNF-alpha stimulation
    Study

    humann: not reported in source

    cultured human gingival fibroblasts
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin beta 4 significantly suppressed the secretion of interleukin-8 (IL-8) following stimulation with tumor necrosis factoralpha (TNF-alpha), suggesting that it may suppress the inflammatory response initiated by pro-inflammatory cytokines.
    1 context sentence
    Summary · context
    The ability of Tbeta(4) to demonstrate similar protective properties in cells of the oral cavity was analyzed using an in vitro model of cultured human gingival fibroblasts.
  2. 02LabIn vitro (cells)Activity measurement

    In cultured human gingival fibroblasts, thymosin beta‑4 did not protect against challenge with lipopolysaccharide from Porphyromonas gingivalis.

    In plain wordsIn cells from human gums, thymosin beta‑4 did not protect against a bacterial toxin from Porphyromonas gingivalis.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeProtection against P. gingivalis lipopolysaccharide
    Study

    humann: not reported in source

    cultured human gingival fibroblasts
    Outcome group
    Cell viability and death · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    By contrast, Tbeta(4) was not effective in protecting fibroblasts from challenge with lipopolysaccharide purified from Porphyromonas gingivalis or Escherichia coli.
    1 context sentence
    Summary · context
    The ability of Tbeta(4) to demonstrate similar protective properties in cells of the oral cavity was analyzed using an in vitro model of cultured human gingival fibroblasts.
  3. 03LabIn vitro (cells)Activity measurement

    In cultured human gingival fibroblasts, thymosin beta‑4 did not protect against challenge with lipopolysaccharide from Escherichia coli.

    In plain wordsIn cells from human gums, thymosin beta‑4 did not protect against a bacterial toxin from Escherichia coli.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeProtection against E. coli lipopolysaccharide
    Study

    humann: not reported in source

    cultured human gingival fibroblasts
    Outcome group
    Cell viability and death · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    By contrast, Tbeta(4) was not effective in protecting fibroblasts from challenge with lipopolysaccharide purified from Porphyromonas gingivalis or Escherichia coli.
    1 context sentence
    Summary · context
    The ability of Tbeta(4) to demonstrate similar protective properties in cells of the oral cavity was analyzed using an in vitro model of cultured human gingival fibroblasts.
  4. 04LabIn vitro (cells)Activity measurement

    In cultured human gingival fibroblasts, thymosin beta‑4 protected against the cytotoxic effects of chlorhexidine digluconate.

    In plain wordsIn cells from human gums, thymosin beta‑4 protected against damage from the mouthrinse ingredient chlorhexidine.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseChlorhexidine digluconate cytotoxicity
    Study

    humann: not reported in source

    cultured human gingival fibroblasts
    Outcome group
    Cell viability and death · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin beta 4 was able to protect gingival fibroblasts against the known cytotoxic effects of chlorhexidine digluconate, a mouthrinse containing chlorhexidine digluconate, and carbamide peroxide.
    1 context sentence
    Summary · context
    The ability of Tbeta(4) to demonstrate similar protective properties in cells of the oral cavity was analyzed using an in vitro model of cultured human gingival fibroblasts.
  5. 05LabIn vitro (cells)Activity measurement

    In cultured human gingival fibroblasts, thymosin beta‑4 protected against the cytotoxic effects of carbamide peroxide.

    In plain wordsIn cells from human gums, thymosin beta‑4 protected against damage from carbamide peroxide.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCarbamide peroxide cytotoxicity
    Study

    humann: not reported in source

    cultured human gingival fibroblasts
    Outcome group
    Cell viability and death · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin beta 4 was able to protect gingival fibroblasts against the known cytotoxic effects of chlorhexidine digluconate, a mouthrinse containing chlorhexidine digluconate, and carbamide peroxide.
    1 context sentence
    Summary · context
    The ability of Tbeta(4) to demonstrate similar protective properties in cells of the oral cavity was analyzed using an in vitro model of cultured human gingival fibroblasts.
  6. 06LabIn vitro (cells)Activity measurement

    In cultured human gingival fibroblasts, thymosin beta‑4 protected against apoptosis induced by TNF-alpha.

    In plain wordsIn cells from human gums, thymosin beta‑4 protected against cell death caused by TNF-alpha.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseTNF-alpha-induced apoptosis
    Study

    humann: not reported in source

    cultured human gingival fibroblasts
    Outcome group
    Cell viability and death · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, Tbeta(4) was able to protect gingival fibroblasts from the apoptosis that is induced by stimulation with TNF-alpha or by exposure to chlorhexidine.
    1 context sentence
    Summary · context
    The ability of Tbeta(4) to demonstrate similar protective properties in cells of the oral cavity was analyzed using an in vitro model of cultured human gingival fibroblasts.
  7. 07LabIn vitro (cells)Activity measurement

    In cultured human gingival fibroblasts, thymosin beta‑4 protected against apoptosis induced by exposure to chlorhexidine.

    In plain wordsIn cells from human gums, thymosin beta‑4 protected against cell death caused by chlorhexidine.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseChlorhexidine-induced apoptosis
    Study

    humann: not reported in source

    cultured human gingival fibroblasts
    Outcome group
    Cell viability and death · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, Tbeta(4) was able to protect gingival fibroblasts from the apoptosis that is induced by stimulation with TNF-alpha or by exposure to chlorhexidine.
    1 context sentence
    Summary · context
    The ability of Tbeta(4) to demonstrate similar protective properties in cells of the oral cavity was analyzed using an in vitro model of cultured human gingival fibroblasts.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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