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Study · Animal study (in vivo) · rat · 2008

6 results

Feeding behavior during long-term hexarelin administration in young and old rats.

Bresciani E, Pitsikas N, Tamiazzo L, Luoni M, Bulgarelli I, Cocchi D, Locatelli V, Torsello A

Journal of endocrinological investigation1 Jul 2008Cited by 6 (Europe PMC)

PMID18787385 (opens in a new tab)DOI10.1007/bf03345618 (opens in a new tab)PepBankPUB-18787385
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In young rats, a dose of 80 microg/kg hexarelin s.c. gave reproducibly maximal stimulation of food consumption in a dose-response study (80-320 microg/kg).

    In plain wordsIn young rats, hexarelin at 80 micrograms per kilogram increased food intake as much as higher doses.

    Peptide
    Hexarelin
    Outcome
    IncreaseFood consumption, dose-response in young rats
    Study

    ratn: not reported in source

    Young (3-month-old) rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    80-320 microg/kg · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    A dose-response study (80-320 microg/kg, s.c.) revealed that hexarelin at the dose of 80 microg/kg gave reproducibly maximal stimulation of food consumption in young as well as in old rats.
    1 context sentence
    Summary · context
    The aim of the present study was first to identify the lowest dose of hexarelin giving maximal stimulation of food intake both in young (3-month-old) and old rats (24-month-old).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In old rats, a dose of 80 microg/kg hexarelin s.c. gave reproducibly maximal stimulation of food consumption in a dose-response study (80-320 microg/kg).

    In plain wordsIn old rats, hexarelin at 80 micrograms per kilogram increased food intake as much as higher doses.

    Peptide
    Hexarelin
    Outcome
    IncreaseFood consumption, dose-response in old rats
    Study

    ratn: not reported in source

    Old (24-month-old) rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    80-320 microg/kg · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    A dose-response study (80-320 microg/kg, s.c.) revealed that hexarelin at the dose of 80 microg/kg gave reproducibly maximal stimulation of food consumption in young as well as in old rats.
    1 context sentence
    Summary · context
    The aim of the present study was first to identify the lowest dose of hexarelin giving maximal stimulation of food intake both in young (3-month-old) and old rats (24-month-old).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In young male rats, daily hexarelin 80 microg/kg s.c. for 8 weeks maintained a persistent significant orexigenic action.

    In plain wordsIn young male rats, daily hexarelin kept food intake raised throughout 8 weeks of treatment.

    Peptide
    Hexarelin
    Outcome
    IncreaseFood intake during 8-week treatment in young rats
    Study

    ratn: not reported in source

    Young male rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    80 microg/kg once daily · subcutaneous · 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    The outcome of the chronic study was that hexarelin (80 microg/kg, s.c., once daily) maintained a persistent significant orexigenic action throughout the treatment period, both in young and old rats.
    1 context sentence
    Summary · context
    Second, we evaluated the effect of 8-week daily sc treatment with hexarelin in young and old male rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In old male rats, daily hexarelin 80 microg/kg s.c. for 8 weeks maintained a persistent significant orexigenic action.

    In plain wordsIn old male rats, daily hexarelin kept food intake raised throughout 8 weeks of treatment.

    Peptide
    Hexarelin
    Outcome
    IncreaseFood intake during 8-week treatment in old rats
    Study

    ratn: not reported in source

    Old male rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    80 microg/kg once daily · subcutaneous · 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    The outcome of the chronic study was that hexarelin (80 microg/kg, s.c., once daily) maintained a persistent significant orexigenic action throughout the treatment period, both in young and old rats.
    1 context sentence
    Summary · context
    Second, we evaluated the effect of 8-week daily sc treatment with hexarelin in young and old male rats.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In young male rats, 8 weeks of hexarelin treatment did not affect body weight gain.

    In plain wordsIn young male rats, 8 weeks of hexarelin did not change body weight gain.

    Peptide
    Hexarelin
    Outcome
    No significant changeBody weight gain in young rats
    Study

    ratn: not reported in source

    Young male rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    80 microg/kg once daily · subcutaneous · 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    Interestingly, hexarelin treatment did not affect body weight gain either in young or old rats.
    1 context sentence
    Summary · context
    Second, we evaluated the effect of 8-week daily sc treatment with hexarelin in young and old male rats.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In old male rats, 8 weeks of hexarelin treatment did not affect body weight gain.

    In plain wordsIn old male rats, 8 weeks of hexarelin did not change body weight gain.

    Peptide
    Hexarelin
    Outcome
    No significant changeBody weight gain in old rats
    Study

    ratn: not reported in source

    Old male rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    80 microg/kg once daily · subcutaneous · 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    Interestingly, hexarelin treatment did not affect body weight gain either in young or old rats.
    1 context sentence
    Summary · context
    Second, we evaluated the effect of 8-week daily sc treatment with hexarelin in young and old male rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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