Gastric pentadecapeptide BPC 157 as an effective therapy for muscle crush injury in the rat.

Novinscak T, Brcic L, Staresinic M, Jukic I, Radic B, Pevec D, Mise S, Tomasovic S, Brcic I, Banic T, Jakir A, Buljat G and 5 more

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Anic T, Zoricic I, Romic Z, Seiwerth S, Sikiric P

Surgery today31 Jul 2008Cited by 41 (Europe PMC)

PMID18668315DOI10.1007/s00595-007-3706-2PepBankPUB-18668315

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with muscle crush injury, BPC‑157 improved macroscopic muscle healing, with less hematoma and edema.
In plain wordsIn rats with a crushed muscle, BPC‑157 gave less bruising and swelling.
Peptide
BPC-157
Outcome
DecreaseHematoma and edema (macroscopic healing)
Study
ratn: not reported in source
Gastrocnemius muscle crush injury
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
Dose not stated · intraperitoneal or local cream · once at injury (sacrifice at 2 h), or once a day for 14 daysAs given in this study (rat).
Source sentences
Summary
improved muscle healing, macroscopically (less hematoma and edema
1 context sentence(design, population, supporting numbers)
Summary · context
In crushed rats (force delivered 0.727 Ns/cm2), BPC 157 was applied either intraperitoneally or locally, as a thin cream layer, immediately after injury (sacrifice at 2 h), and once a day for 14 days.
Report a problemFND-1866831501
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with muscle crush injury, BPC‑157 treatment was followed by no post-injury leg contracture.
In plain wordsIn rats with a crushed muscle, BPC‑157 treatment was followed by no stiff, shortened leg.
Peptide
BPC-157
Outcome
DecreasePost-injury leg contracture
Study
ratn: not reported in source
Gastrocnemius muscle crush injury
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
Dose not stated · intraperitoneal or local cream · once at injury (sacrifice at 2 h), or once a day for 14 daysAs given in this study (rat).
Source sentences
Summary
no post-injury leg contracture
1 context sentence(design, population, supporting numbers)
Summary · context
In crushed rats (force delivered 0.727 Ns/cm2), BPC 157 was applied either intraperitoneally or locally, as a thin cream layer, immediately after injury (sacrifice at 2 h), and once a day for 14 days.
Report a problemFND-1866831502
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with muscle crush injury, BPC‑157 improved muscle healing microscopically.
In plain wordsIn rats with a crushed muscle, BPC‑157 improved muscle healing seen under the microscope.
Peptide
BPC-157
Outcome
IncreaseMicroscopic muscle healing
Study
ratn: not reported in source
Gastrocnemius muscle crush injury
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
Dose not stated · intraperitoneal or local cream · once at injury (sacrifice at 2 h), or once a day for 14 daysAs given in this study (rat).
Source sentences
Summary
microscopically
1 context sentence(design, population, supporting numbers)
Summary · context
In crushed rats (force delivered 0.727 Ns/cm2), BPC 157 was applied either intraperitoneally or locally, as a thin cream layer, immediately after injury (sacrifice at 2 h), and once a day for 14 days.
Report a problemFND-1866831503
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with muscle crush injury, BPC‑157 improved muscle healing functionally.
In plain wordsIn rats with a crushed muscle, BPC‑157 improved how well the muscle worked.
Peptide
BPC-157
Outcome
IncreaseFunctional muscle healing
Study
ratn: not reported in source
Gastrocnemius muscle crush injury
Outcome group
Exercise and physical function · Musculoskeletal
Studied dose
Dose not stated · intraperitoneal or local cream · once at injury (sacrifice at 2 h), or once a day for 14 daysAs given in this study (rat).
Source sentences
Summary
functionally
1 context sentence(design, population, supporting numbers)
Summary · context
In crushed rats (force delivered 0.727 Ns/cm2), BPC 157 was applied either intraperitoneally or locally, as a thin cream layer, immediately after injury (sacrifice at 2 h), and once a day for 14 days.
Report a problemFND-1866831504
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with muscle crush injury, BPC‑157 improved muscle healing based on enzyme activity of creatine kinase, lactate dehydrogenase, aspartate aminotransferase and alanine aminotransferase; the direction is not stated.
In plain wordsIn rats with a crushed muscle, BPC‑157 improved healing as judged by muscle and liver enzyme activity.
Peptide
BPC-157
Outcome
Direction not reportedEnzyme activity (creatine kinase, lactate dehydrogenase, AST, ALT)
Study
ratn: not reported in source
Gastrocnemius muscle crush injury
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
Dose not stated · intraperitoneal or local cream · once at injury (sacrifice at 2 h), or once a day for 14 daysAs given in this study (rat).
Source sentences
Summary
enzyme activity (creatine kinase, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase)
1 context sentence(design, population, supporting numbers)
Summary · context
In crushed rats (force delivered 0.727 Ns/cm2), BPC 157 was applied either intraperitoneally or locally, as a thin cream layer, immediately after injury (sacrifice at 2 h), and once a day for 14 days.
Report a problemFND-1866831505

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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