Therapy for unhealed gastrocutaneous fistulas in rats as a model for analogous healing of persistent skin wounds and persistent gastric ulcers: stable gastric pentadecapeptide BPC 157, atropine, ranitidine, and omeprazole.

Skorjanec S, Dolovski Z, Kocman I, Brcic L, Blagaic Boban A, Batelja L, Coric M, Sever M, Klicek R, Berkopic L, Radic B, Drmic D and 12 more

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Kolenc D, Ilic S, Cesarec V, Tonkic A, Zoricic I, Mise S, Staresinic M, Ivica M, Lovric Bencic M, Anic T, Seiwerth S, Sikiric P

Digestive diseases and sciences23 Jul 2008Cited by 19 (Europe PMC)

PMID18649140DOI10.1007/s10620-008-0332-9PepBankPUB-18649140

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with gastrocutaneous fistulas, BPC‑157 gave greater wound healing efficiency than standard anti-ulcer agents.
In plain wordsIn rats with fistulas, BPC‑157 healed wounds better than standard anti-ulcer drugs.
Peptide
BPC-157
Outcome
IncreaseSkin wound healing compared with standard agents
Study
ratn: not reported in source
Gastrocutaneous fistula
Comparator
Atropine, ranitidine, omeprazole
Outcome group
Wound healing · Skin and wound
Studied dose
10 microg/kg in drinking water; 10 microg/kg, 10 ng/kg, 10 pg/kg intraperitoneally · drinking water or intraperitonealAs given in this study (rat).
Source sentences
Summary
Greater anti-ulcer potential and efficiency in wound healing compared with standard agents favor BPC 157, efficient in inflammatory bowel disease (PL-14736, Pliva), given in drinking water or intraperitoneally.
1 context sentence(design, population, supporting numbers)
Summary · context
The healing rate of gastrocutaneous fistula in rat (2-mm-diameter stomach defect, 3-mm-diameter skin defect) validates macro/microscopically and biomechanically a direct skin wound/stomach ulcer relation
Report a problemFND-1864914001
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with gastrocutaneous fistulas, BPC‑157 had greater anti-ulcer potential than standard agents.
In plain wordsIn rats with fistulas, BPC‑157 worked better against ulcers than standard anti-ulcer drugs.
Peptide
BPC-157
Outcome
IncreaseAnti-ulcer potential compared with standard agents
Study
ratn: not reported in source
Gastrocutaneous fistula
Comparator
Atropine, ranitidine, omeprazole
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
10 microg/kg in drinking water; 10 microg/kg, 10 ng/kg, 10 pg/kg intraperitoneally · drinking water or intraperitonealAs given in this study (rat).
Source sentences
Summary
Greater anti-ulcer potential and efficiency in wound healing compared with standard agents favor BPC 157, efficient in inflammatory bowel disease (PL-14736, Pliva), given in drinking water or intraperitoneally.
1 context sentence(design, population, supporting numbers)
Summary · context
The healing rate of gastrocutaneous fistula in rat (2-mm-diameter stomach defect, 3-mm-diameter skin defect) validates macro/microscopically and biomechanically a direct skin wound/stomach ulcer relation
Report a problemFND-1864914002
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with fistulas aggravated by 6-alpha-methylprednisolone, BPC‑157 improved skin healing.
In plain wordsIn rats with fistulas made worse by a steroid, BPC‑157 improved skin healing.
Peptide
BPC-157
Outcome
IncreaseSkin healing after methylprednisolone aggravation
Study
ratn: not reported in source
Gastrocutaneous fistula
Outcome group
Wound healing · Skin and wound
Studied dose
10 microg/kg in drinking water; 10 microg/kg, 10 ng/kg, 10 pg/kg intraperitoneally · drinking water or intraperitonealAs given in this study (rat).
Source sentences
Summary
Even after 6-alpha-methylprednisolone aggravation, BPC 157 promptly improves both skin and stomach mucosa healing, and closure of fistulas, with no leakage after up to 20 ml water intragastrically.
Report a problemFND-1864914003
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with fistulas aggravated by 6-alpha-methylprednisolone, BPC‑157 improved stomach mucosa healing.
In plain wordsIn rats with fistulas made worse by a steroid, BPC‑157 improved healing of the stomach lining.
Peptide
BPC-157
Outcome
IncreaseStomach mucosa healing after methylprednisolone aggravation
Study
ratn: not reported in source
Gastrocutaneous fistula
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
10 microg/kg in drinking water; 10 microg/kg, 10 ng/kg, 10 pg/kg intraperitoneally · drinking water or intraperitonealAs given in this study (rat).
Source sentences
Summary
Even after 6-alpha-methylprednisolone aggravation, BPC 157 promptly improves both skin and stomach mucosa healing, and closure of fistulas, with no leakage after up to 20 ml water intragastrically.
Report a problemFND-1864914004
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with fistulas aggravated by 6-alpha-methylprednisolone, BPC‑157 improved closure of fistulas.
In plain wordsIn rats with fistulas made worse by a steroid, BPC‑157 improved closure of the fistulas.
Peptide
BPC-157
Outcome
IncreaseFistula closure after methylprednisolone aggravation
Study
ratn: not reported in source
Gastrocutaneous fistula
Outcome group
Wound healing · Skin and wound
Studied dose
10 microg/kg in drinking water; 10 microg/kg, 10 ng/kg, 10 pg/kg intraperitoneally · drinking water or intraperitonealAs given in this study (rat).
Source sentences
Summary
Even after 6-alpha-methylprednisolone aggravation, BPC 157 promptly improves both skin and stomach mucosa healing, and closure of fistulas, with no leakage after up to 20 ml water intragastrically.
Report a problemFND-1864914005
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with fistulas aggravated by 6-alpha-methylprednisolone, fistulas treated with BPC‑157 showed no leakage after up to 20 ml water intragastrically.
In plain wordsIn rats with steroid-worsened fistulas, treated fistulas did not leak when the stomach was filled with water.
Peptide
BPC-157
Outcome
DecreaseFistula leakage after intragastric water
Study
ratn: not reported in source
Gastrocutaneous fistula
Outcome group
Wound healing · Skin and wound
Studied dose
10 microg/kg in drinking water; 10 microg/kg, 10 ng/kg, 10 pg/kg intraperitoneally · drinking water or intraperitonealAs given in this study (rat).
Source sentences
Summary
Even after 6-alpha-methylprednisolone aggravation, BPC 157 promptly improves both skin and stomach mucosa healing, and closure of fistulas, with no leakage after up to 20 ml water intragastrically.
Report a problemFND-1864914006

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

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