Postmenopausal increase in KiSS-1, GPR54, and luteinizing hormone releasing hormone (LHRH-1) mRNA in the basal hypothalamus of female rhesus monkeys.

Kim W, Jessen HM, Auger AP, Terasawa E

Peptides21 Jun 2008Cited by 51 (Europe PMC)

PMID18619506PMCIDPMC2612733DOI10.1016/j.peptides.2008.06.005PepBankPUB-18619506

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In female rhesus monkeys, natural KiSS-1 mRNA in the medial basal hypothalamus was higher after menopause than in eugonadal adults.
In plain wordsIn female rhesus monkeys, the brain's own KiSS-1 gene activity in this region was higher after menopause.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseKiSS-1 mRNA in medial basal hypothalamus, postmenopausal vs adult
Study
rhesus monkeyn = 14
Comparator
Eugonadal adult females
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Results indicate that KiSS-1, GPR54, and LHRH-1 mRNA levels in the medial basal hypothalamus (MBH) in postmenopausal females (28.3+/-1.1 years of age, n=5) were all significantly higher than that in eugonadal adult females (14.7+/-2.1 years of age, n=9), whereas KiSS-1, GPR54, and LHRH-1 mRNA levels…
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study we investigated whether KiSS-1, GPR54, and LHRH-1 mRNA in the brain change after menopause in female rhesus monkeys using quantitative real-time PCR.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1861950601
02AnimalEndogenous levelAnimal study (in vivo)Other
In female rhesus monkeys, natural KiSS-1 mRNA in the preoptic area did not change significantly between postmenopausal and eugonadal adults.
In plain wordsIn female rhesus monkeys, the brain's own KiSS-1 gene activity in the preoptic area did not differ with age group.
Peptide
Kisspeptin-54 (metastin)
Outcome
No significant changeKiSS-1 mRNA in preoptic area, postmenopausal vs adult
Study
rhesus monkeyn = 14
Comparator
Eugonadal adult females
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Results indicate that KiSS-1, GPR54, and LHRH-1 mRNA levels in the medial basal hypothalamus (MBH) in postmenopausal females (28.3+/-1.1 years of age, n=5) were all significantly higher than that in eugonadal adult females (14.7+/-2.1 years of age, n=9), whereas KiSS-1, GPR54, and LHRH-1 mRNA levels…
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study we investigated whether KiSS-1, GPR54, and LHRH-1 mRNA in the brain change after menopause in female rhesus monkeys using quantitative real-time PCR.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1861950602
03AnimalEndogenous levelAnimal study (in vivo)Other
In young female rhesus monkeys, natural KiSS-1 mRNA in the medial basal hypothalamus was higher after ovariectomy than in ovarian intact females.
In plain wordsIn young female rhesus monkeys, the brain's own KiSS-1 gene activity in this region was higher after the ovaries were removed.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseKiSS-1 mRNA in medial basal hypothalamus, ovariectomized vs intact
Study
rhesus monkeyn: not reported in source
Comparator
Ovarian intact young females
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Results indicate that KiSS-1 and LHRH-1 mRNA levels in the MBH, not POA, in ovariectomized females were significantly higher than those in ovarian intact females
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study we investigated whether KiSS-1, GPR54, and LHRH-1 mRNA in the brain change after menopause in female rhesus monkeys using quantitative real-time PCR.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1861950603
04AnimalEndogenous levelAnimal study (in vivo)Other
In young female rhesus monkeys, natural KiSS-1 mRNA in the preoptic area did not differ significantly after ovariectomy.
In plain wordsIn young female rhesus monkeys, the brain's own KiSS-1 gene activity in the preoptic area did not differ after the ovaries were removed.
Peptide
Kisspeptin-54 (metastin)
Outcome
No significant changeKiSS-1 mRNA in preoptic area, ovariectomized vs intact
Study
rhesus monkeyn: not reported in source
Comparator
Ovarian intact young females
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Results indicate that KiSS-1 and LHRH-1 mRNA levels in the MBH, not POA, in ovariectomized females were significantly higher than those in ovarian intact females, whereas GPR54 mRNA levels in ovariectomized females had a tendency to be elevated in the MBH, although the values were not quite statistically significant.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study we investigated whether KiSS-1, GPR54, and LHRH-1 mRNA in the brain change after menopause in female rhesus monkeys using quantitative real-time PCR.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1861950604

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Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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