Modulation of early functional recovery of Achilles tendon to bone unit after transection by BPC 157 and methylprednisolone.

Krivic A, Majerovic M, Jelic I, Seiwerth S, Sikiric P

Inflammation research : official journal of the European Histamine Research Society ... [et al.]1 May 2008Cited by 29 (Europe PMC)

PMID18594781DOI10.1007/s00011-007-7056-8PepBankPUB-18594781

Publisher page PubMedAsk about this study

Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with Achilles tendon to bone transection, BPC‑157 improved early functional recovery, with increased Achilles functional index at all time points.
In plain wordsIn rats with a cut Achilles tendon, BPC‑157 improved early functional recovery compared with saline.
Peptide
BPC-157
Outcome
IncreaseAchilles functional index (AFI)
Study
ratn: not reported in source
Achilles tendon to bone transection
Comparator
Normal saline
Outcome group
Tendon and ligament healing · Musculoskeletal
Studied dose
10 microg/kg · intraperitoneal · 1-4 daysAs given in this study (rat).
Source sentences
Summary
BPC 157 improved functional recovery (AFI values increased at all time points, p <0.05)
2 context sentences(design, population, supporting numbers)
Summary · context
Surgical transection of the right Achilles tendon to bone area was performed in seventy two Wistar Albino male rats.
Summary · context
Agents (stable peptide BPC 157 10 microg methylprednisolone 5 mg, normal saline 5 ml) were given alone (/kg b.w., intraperitoneally, once daily, first 30 min after surgery, last 24 h before analysis).
Report a problemFND-1859478101
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with Achilles tendon to bone transection, BPC‑157 decreased myeloperoxidase activity in the healing tendon.
In plain wordsIn rats with a cut Achilles tendon, BPC‑157 lowered a marker of inflammation compared with saline.
Peptide
BPC-157
Outcome
DecreaseMyeloperoxidase (MPO) activity
Study
ratn: not reported in source
Achilles tendon to bone transection
Comparator
Normal saline
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
10 microg/kg · intraperitoneal · 1-4 daysAs given in this study (rat).
Source sentences
Summary
decreased myeloperoxidase (MPO) activity and histological inflammatory cell influx, p <0.05)
2 context sentences(design, population, supporting numbers)
Summary · context
Surgical transection of the right Achilles tendon to bone area was performed in seventy two Wistar Albino male rats.
Summary · context
Agents (stable peptide BPC 157 10 microg methylprednisolone 5 mg, normal saline 5 ml) were given alone (/kg b.w., intraperitoneally, once daily, first 30 min after surgery, last 24 h before analysis).
Report a problemFND-1859478102
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with Achilles tendon to bone transection, BPC‑157 decreased histological inflammatory cell influx.
In plain wordsIn rats with a cut Achilles tendon, BPC‑157 reduced the number of inflammatory cells in the healing tendon compared with saline.
Peptide
BPC-157
Outcome
DecreaseHistological inflammatory cell influx
Study
ratn: not reported in source
Achilles tendon to bone transection
Comparator
Normal saline
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
10 microg/kg · intraperitoneal · 1-4 daysAs given in this study (rat).
Source sentences
Summary
decreased myeloperoxidase (MPO) activity and histological inflammatory cell influx, p <0.05)
2 context sentences(design, population, supporting numbers)
Summary · context
Surgical transection of the right Achilles tendon to bone area was performed in seventy two Wistar Albino male rats.
Summary · context
Agents (stable peptide BPC 157 10 microg methylprednisolone 5 mg, normal saline 5 ml) were given alone (/kg b.w., intraperitoneally, once daily, first 30 min after surgery, last 24 h before analysis).
Report a problemFND-1859478103
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with Achilles tendon to bone transection, BPC‑157 increased new blood vessel formation, with a higher vascular index.
In plain wordsIn rats with a cut Achilles tendon, BPC‑157 increased new blood vessel formation compared with saline.
Peptide
BPC-157
Outcome
IncreaseVascular index (new blood vessel formation)
Study
ratn: not reported in source
Achilles tendon to bone transection
Comparator
Normal saline
Outcome group
Tendon and ligament healing · Musculoskeletal
Studied dose
10 microg/kg · intraperitoneal · 1-4 daysAs given in this study (rat).
Source sentences
Summary
increased new blood vessel formation (increased vascular index, p <0.05)
2 context sentences(design, population, supporting numbers)
Summary · context
Surgical transection of the right Achilles tendon to bone area was performed in seventy two Wistar Albino male rats.
Summary · context
Agents (stable peptide BPC 157 10 microg methylprednisolone 5 mg, normal saline 5 ml) were given alone (/kg b.w., intraperitoneally, once daily, first 30 min after surgery, last 24 h before analysis).
Report a problemFND-1859478104

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.