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Study · Not a test of the peptide alone · 2008

6 results

Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway.

Xu X, Chua CC, Gao J, Chua KW, Wang H, Hamdy RC, Chua BH

Brain research16 Jun 2008Cited by 134 (Europe PMC)

PMID18590709 (opens in a new tab)PMCIDPMC2575816 (opens in a new tab)DOI10.1016/j.brainres.2008.06.018 (opens in a new tab)PepBankPUB-18590709
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    In mice with middle cerebral artery occlusion, intraventricular HNG significantly elevated p-Akt levels after cerebral ischemia/reperfusion injury.

    In plain wordsIn mice with a stroke-like injury, a Humanin variant raised Akt activity in the brain.

    Peptide
    Humanin
    Outcome
    Increasep-Akt level after cerebral ischemia/reperfusion
    Study

    mousen: not reported in source

    Mouse middle cerebral artery occlusion
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    HNG treatment significantly elevated p-Akt levels after cerebral I/R injury and decreased infarct volume.
    1 context sentence
    Summary · context
    Mouse brains were injected intraventricularly with HNG before being subjected to middle cerebral artery occlusion (MCAO).

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In mice with middle cerebral artery occlusion, HNG treatment decreased infarct volume.

    In plain wordsIn mice with a stroke-like injury, a Humanin variant reduced the size of the damaged brain area.

    Peptide
    Humanin
    Outcome
    DecreaseInfarct volume after cerebral ischemia/reperfusion
    Study

    mousen: not reported in source

    Mouse middle cerebral artery occlusion
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    HNG treatment significantly elevated p-Akt levels after cerebral I/R injury and decreased infarct volume.
    1 context sentence
    Summary · context
    Mouse brains were injected intraventricularly with HNG before being subjected to middle cerebral artery occlusion (MCAO).

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    The protective effect of HNG on infarct size was attenuated by wortmannin and Akti-1/2 in mice with middle cerebral artery occlusion.

    In plain wordsIn mice with a stroke-like injury, blocking the PI3K/Akt pathway weakened the protective effect of a Humanin variant.

    Peptide
    Humanin
    Outcome
    DecreasePI3K/Akt inhibitors on HNG effect on infarct size
    Study

    mousen: not reported in source

    Mouse middle cerebral artery occlusion
    Comparator
    HNG alone
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The protective effect of HNG on infarct size was attenuated by wortmannin and Akti-1/2.
    1 context sentence
    Summary · context
    Mouse brains were injected intraventricularly with HNG before being subjected to middle cerebral artery occlusion (MCAO).

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 04LabNot a test of Humanin aloneIn vitro (cells)Efficacy outcome

    HNG, a Humanin variant, increased cell viability after oxygen-glucose deprivation in mouse primary cortical neurons.

    In plain wordsIn mouse nerve cells in a dish, a Humanin variant raised cell survival after oxygen and glucose were cut off.

    Peptide
    Humanin
    Outcome
    IncreaseCell viability after oxygen-glucose deprivation
    Study

    mousen: not reported in source

    Mouse primary cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    HNG increased cell viability after OGD in primary cortical neurons
    1 context sentence
    Summary · context
    Oxygen-glucose deprivation (OGD) was performed in cultured mouse primary cortical neurons for 60 min.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  5. 05LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    The PI3K/Akt inhibitors wortmannin and Akti-1/2 attenuated the protective effect of HNG on cell viability after oxygen-glucose deprivation.

    In plain wordsIn mouse nerve cells in a dish, blocking the PI3K/Akt pathway weakened the protection from a Humanin variant.

    Peptide
    Humanin
    Outcome
    DecreasePI3K/Akt inhibitors on HNG protection after oxygen-glucose deprivation
    Study

    mousen: not reported in source

    Mouse primary cortical neurons
    Comparator
    HNG alone
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    whereas the PI3K/Akt inhibitors wortmannin and Akti-1/2 attenuated the protective effect of HNG.
    1 context sentence
    Summary · context
    Oxygen-glucose deprivation (OGD) was performed in cultured mouse primary cortical neurons for 60 min.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  6. 06LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    HNG rapidly increased Akt phosphorylation in mouse primary cortical neurons, and wortmannin and Akti-1/2 inhibited this effect.

    In plain wordsIn mouse nerve cells in a dish, a Humanin variant quickly raised Akt activity, and pathway blockers stopped this.

    Peptide
    Humanin
    Outcome
    IncreaseAkt phosphorylation in cortical neurons
    Study

    mousen: not reported in source

    Mouse primary cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    HNG rapidly increased Akt phosphorylation, an effect that was inhibited by wortmannin and Akti-1/2.
    1 context sentence
    Summary · context
    Oxygen-glucose deprivation (OGD) was performed in cultured mouse primary cortical neurons for 60 min.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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