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Study · Not a test of the peptide alone · 2008

3 results

Bioactive peptides control receptor for advanced glycated end product-induced elevation of kidney insulin receptor substrate 2 and reduce albuminuria in diabetic mice.

Singh BK, Mascarenhas DD

American journal of nephrology20 Jun 2008Cited by 7 (Europe PMC)

PMID18566543 (opens in a new tab)DOI10.1159/000141042 (opens in a new tab)PepBankPUB-18566543
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In db/db mice, daily subcutaneous humanin or the PKC-beta2 inhibitor peptide NPKC, reported together, was followed by a significant reduction in albuminuria (p < 0.05).

    In plain wordsIn diabetic mice, humanin or another peptide, reported together, lowered the amount of protein in the urine.

    Peptide
    Humanin
    Outcome
    DecreaseAlbuminuria in db/db mice
    Study

    mousen: not reported in source

    db/db mice
    Outcome group
    Kidney function · Kidney and urinary

    Source sentences

    Summary
    In animals receiving daily subcutaneous bolus injections (weeks 8-13) of 20 microg/day humanin or 40 microg/day protein kinase C (NPKC) (a PKC-beta2 inhibitor peptide), there was a significant reduction in albuminuria, insulin receptor substrate 2 (IRS-2) and phospho-Akt (Ser473) levels in kidney ti…
    1 context sentence
    Summary · context
    Sixteen-week-old db/db mice exhibit significantly elevated blood glucose and albuminuria.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    In db/db mice, daily subcutaneous humanin or the PKC-beta2 inhibitor peptide NPKC, reported together, was followed by a significant reduction in insulin receptor substrate 2 (IRS-2) in kidney tissue extracts (p < 0.05).

    In plain wordsIn diabetic mice, humanin or another peptide, reported together, lowered the level of the IRS-2 protein in kidney tissue.

    Peptide
    Humanin
    Outcome
    DecreaseKidney IRS-2 level in db/db mice
    Study

    mousen: not reported in source

    db/db mice
    Outcome group
    Kidney function · Kidney and urinary

    Source sentences

    Summary
    In animals receiving daily subcutaneous bolus injections (weeks 8-13) of 20 microg/day humanin or 40 microg/day protein kinase C (NPKC) (a PKC-beta2 inhibitor peptide), there was a significant reduction in albuminuria, insulin receptor substrate 2 (IRS-2) and phospho-Akt (Ser473) levels in kidney ti…
    1 context sentence
    Summary · context
    Sixteen-week-old db/db mice exhibit significantly elevated blood glucose and albuminuria.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    In db/db mice, daily subcutaneous humanin or the PKC-beta2 inhibitor peptide NPKC, reported together, was followed by a significant reduction in phospho-Akt (Ser473) in kidney tissue extracts (p < 0.05).

    In plain wordsIn diabetic mice, humanin or another peptide, reported together, lowered the level of phosphorylated Akt in kidney tissue.

    Peptide
    Humanin
    Outcome
    DecreaseKidney phospho-Akt (Ser473) level in db/db mice
    Study

    mousen: not reported in source

    db/db mice
    Outcome group
    Kidney function · Kidney and urinary

    Source sentences

    Summary
    In animals receiving daily subcutaneous bolus injections (weeks 8-13) of 20 microg/day humanin or 40 microg/day protein kinase C (NPKC) (a PKC-beta2 inhibitor peptide), there was a significant reduction in albuminuria, insulin receptor substrate 2 (IRS-2) and phospho-Akt (Ser473) levels in kidney ti…
    1 context sentence
    Summary · context
    Sixteen-week-old db/db mice exhibit significantly elevated blood glucose and albuminuria.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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