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Study · Animal study (in vivo) · rat · 2009

19 results

The protective effects of carnosine and melatonin in ischemia-reperfusion injury in the rat liver.

Baykara B, Tekmen I, Pekcetin C, Ulukus C, Tuncel P, Sagol O, Ormen M, Ozogul C

Acta histochemica12 Jun 2008Cited by 29 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study19

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with liver ischemia-reperfusion injury, sinusoidal dilatation was less pronounced with carnosine than without treatment.

    In plain wordsIn rats, carnosine reduced liver sinusoidal dilatation compared with untreated ischemia-reperfusion injury.

    Outcome
    DecreaseSinusoidal dilatation
    Study

    ratn: not reported in source

    liver ischemia-reperfusion injury
    Comparator
    ischemia-reperfusion group
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Sinusoidal dilatation, congestion and neutrophil infiltration were observed in the ischemia-reperfusion group while these symptoms were less pronounced in the treatment groups.
    2 context sentences
    Summary · context
    Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
    Summary · context
    Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with liver ischemia-reperfusion injury, congestion was less pronounced with carnosine than without treatment.

    In plain wordsIn rats, carnosine reduced liver congestion compared with untreated ischemia-reperfusion injury.

    Outcome
    DecreaseCongestion
    Study

    ratn: not reported in source

    liver ischemia-reperfusion injury
    Comparator
    ischemia-reperfusion group
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Sinusoidal dilatation, congestion and neutrophil infiltration were observed in the ischemia-reperfusion group while these symptoms were less pronounced in the treatment groups.
    2 context sentences
    Summary · context
    Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
    Summary · context
    Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with liver ischemia-reperfusion injury, neutrophil infiltration was less pronounced with carnosine than without treatment.

    In plain wordsIn rats, carnosine reduced neutrophil infiltration compared with untreated liver ischemia-reperfusion injury.

    Outcome
    DecreaseNeutrophil infiltration
    Study

    ratn: not reported in source

    liver ischemia-reperfusion injury
    Comparator
    ischemia-reperfusion group
    Outcome group
    Inflammation markers · Liver
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Sinusoidal dilatation, congestion and neutrophil infiltration were observed in the ischemia-reperfusion group while these symptoms were less pronounced in the treatment groups.
    2 context sentences
    Summary · context
    Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
    Summary · context
    Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with liver ischemia-reperfusion injury, carnosine lowered alanine aminotransferase levels versus the untreated injury group.

    In plain wordsIn rats, carnosine lowered alanine aminotransferase levels compared with untreated liver injury.

    Outcome
    DecreaseAlanine aminotransferase
    Study

    ratn: not reported in source

    liver ischemia-reperfusion injury
    Comparator
    ischemia-reperfusion group
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Alanine aminotransferase, aspartate aminotransferase and myeloperoxidase levels were increased in the ischemia-reperfusion group while they were lowered in the treatment groups.
    2 context sentences
    Summary · context
    Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
    Summary · context
    Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with liver ischemia-reperfusion injury, carnosine lowered aspartate aminotransferase levels versus the untreated injury group.

    In plain wordsIn rats, carnosine lowered aspartate aminotransferase levels compared with untreated liver injury.

    Outcome
    DecreaseAspartate aminotransferase
    Study

    ratn: not reported in source

    liver ischemia-reperfusion injury
    Comparator
    ischemia-reperfusion group
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Alanine aminotransferase, aspartate aminotransferase and myeloperoxidase levels were increased in the ischemia-reperfusion group while they were lowered in the treatment groups.
    2 context sentences
    Summary · context
    Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
    Summary · context
    Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with liver ischemia-reperfusion injury, carnosine lowered myeloperoxidase levels versus the untreated injury group.

    In plain wordsIn rats, carnosine lowered myeloperoxidase levels compared with untreated liver injury.

    Outcome
    DecreaseMyeloperoxidase
    Study

    ratn: not reported in source

    liver ischemia-reperfusion injury
    Comparator
    ischemia-reperfusion group
    Outcome group
    Inflammation markers · Liver
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Alanine aminotransferase, aspartate aminotransferase and myeloperoxidase levels were increased in the ischemia-reperfusion group while they were lowered in the treatment groups.
    2 context sentences
    Summary · context
    Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
    Summary · context
    Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with liver ischemia-reperfusion injury, glutathione tended to increase with carnosine versus the untreated injury group.

    In plain wordsIn rats, glutathione tended to increase with carnosine compared with untreated liver injury.

    Outcome
    IncreaseGlutathione
    Study

    ratn: not reported in source

    liver ischemia-reperfusion injury
    Comparator
    ischemia-reperfusion group
    Outcome group
    Oxidative stress · Liver
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Glutathione level was low in the ischemia-reperfusion group while it tended to increase in the ischemia-reperfusion+carnosine administered and ischemia-reperfusion+carnosine+melatonin administered groups.
    2 context sentences
    Summary · context
    Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
    Summary · context
    Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with liver ischemia-reperfusion injury, carnosine lowered apoptotic cell numbers versus the untreated injury group.

    In plain wordsIn rats, carnosine reduced apoptotic cells compared with untreated liver injury.

    Outcome
    DecreaseApoptotic cells
    Study

    ratn: not reported in source

    liver ischemia-reperfusion injury
    Comparator
    ischemia-reperfusion group
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    There was an increase in the number of apoptotic cells in the ischemia-reperfusion group while this number was lowered in the treatment groups.
    2 context sentences
    Summary · context
    Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
    Summary · context
    Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats, carnosine reversed liver ischemia-reperfusion structural and biochemical alterations more effectively than melatonin.

    In plain wordsIn rats, carnosine reversed liver injury changes more effectively than melatonin.

    Outcome
    DecreaseStructural and biochemical alterations
    Study

    ratn: not reported in source

    liver ischemia-reperfusion injury
    Comparator
    melatonin
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Carnosine was more effective than melatonin in the reversal of structural and biochemical alterations that resulted from ischemia-reperfusion injury.
    2 context sentences
    Summary · context
    Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
    Summary · context
    Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats with liver ischemia-reperfusion injury, carnosine plus melatonin yielded better outcomes than melatonin alone.

    In plain wordsIn rats, carnosine plus melatonin produced better liver injury outcomes than melatonin alone.

    Outcome
    Direction not reportedOverall outcomes with combination versus melatonin
    Study

    ratn: not reported in source

    liver ischemia-reperfusion injury
    Comparator
    melatonin alone
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    The administration of melatonin and carnosine together yielded better outcomes compared to the sole administration of each agent.
    2 context sentences
    Summary · context
    Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
    Summary · context
    Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.

Studies that did not test the peptide alone9

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

  1. 11AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome

    In rats, carnosine plus melatonin reduced sinusoidal dilatation versus untreated liver ischemia-reperfusion injury.

    In plain wordsIn rats, carnosine plus melatonin reduced sinusoidal dilatation compared with untreated liver injury.

    Outcome
    DecreaseSinusoidal dilatation with combination
    Study

    ratn: not reported in source

    liver ischemia-reperfusion injury
    Comparator
    ischemia-reperfusion group
    Outcome group
    Liver fat and liver function · Liver

    Source sentences

    Summary
    Sinusoidal dilatation, congestion and neutrophil infiltration were observed in the ischemia-reperfusion group while these symptoms were less pronounced in the treatment groups.
    2 context sentences
    Summary · context
    Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
    Summary · context
    Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  2. 12AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome

    In rats, carnosine plus melatonin reduced congestion versus untreated liver ischemia-reperfusion injury.

    In plain wordsIn rats, carnosine plus melatonin reduced congestion compared with untreated liver injury.

    Outcome
    DecreaseCongestion with combination
    Study

    ratn: not reported in source

    liver ischemia-reperfusion injury
    Comparator
    ischemia-reperfusion group
    Outcome group
    Liver fat and liver function · Liver

    Source sentences

    Summary
    Sinusoidal dilatation, congestion and neutrophil infiltration were observed in the ischemia-reperfusion group while these symptoms were less pronounced in the treatment groups.
    2 context sentences
    Summary · context
    Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
    Summary · context
    Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  3. 13AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome

    In rats, carnosine plus melatonin reduced neutrophil infiltration versus untreated liver ischemia-reperfusion injury.

    In plain wordsIn rats, carnosine plus melatonin reduced neutrophil infiltration compared with untreated liver injury.

    Outcome
    DecreaseNeutrophil infiltration with combination
    Study

    ratn: not reported in source

    liver ischemia-reperfusion injury
    Comparator
    ischemia-reperfusion group
    Outcome group
    Inflammation markers · Liver

    Source sentences

    Summary
    Sinusoidal dilatation, congestion and neutrophil infiltration were observed in the ischemia-reperfusion group while these symptoms were less pronounced in the treatment groups.
    2 context sentences
    Summary · context
    Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
    Summary · context
    Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  4. 14AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome

    In rats, carnosine plus melatonin lowered alanine aminotransferase versus untreated liver ischemia-reperfusion injury.

    In plain wordsIn rats, carnosine plus melatonin lowered alanine aminotransferase compared with untreated liver injury.

    Outcome
    DecreaseAlanine aminotransferase with combination
    Study

    ratn: not reported in source

    liver ischemia-reperfusion injury
    Comparator
    ischemia-reperfusion group
    Outcome group
    Liver fat and liver function · Liver

    Source sentences

    Summary
    Alanine aminotransferase, aspartate aminotransferase and myeloperoxidase levels were increased in the ischemia-reperfusion group while they were lowered in the treatment groups.
    2 context sentences
    Summary · context
    Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
    Summary · context
    Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  5. 15AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome

    In rats, carnosine plus melatonin lowered aspartate aminotransferase versus untreated liver ischemia-reperfusion injury.

    In plain wordsIn rats, carnosine plus melatonin lowered aspartate aminotransferase compared with untreated liver injury.

    Outcome
    DecreaseAspartate aminotransferase with combination
    Study

    ratn: not reported in source

    liver ischemia-reperfusion injury
    Comparator
    ischemia-reperfusion group
    Outcome group
    Liver fat and liver function · Liver

    Source sentences

    Summary
    Alanine aminotransferase, aspartate aminotransferase and myeloperoxidase levels were increased in the ischemia-reperfusion group while they were lowered in the treatment groups.
    2 context sentences
    Summary · context
    Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
    Summary · context
    Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  6. 16AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome

    In rats, carnosine plus melatonin lowered myeloperoxidase versus untreated liver ischemia-reperfusion injury.

    In plain wordsIn rats, carnosine plus melatonin lowered myeloperoxidase compared with untreated liver injury.

    Outcome
    DecreaseMyeloperoxidase with combination
    Study

    ratn: not reported in source

    liver ischemia-reperfusion injury
    Comparator
    ischemia-reperfusion group
    Outcome group
    Inflammation markers · Liver

    Source sentences

    Summary
    Alanine aminotransferase, aspartate aminotransferase and myeloperoxidase levels were increased in the ischemia-reperfusion group while they were lowered in the treatment groups.
    2 context sentences
    Summary · context
    Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
    Summary · context
    Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  7. 17AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome

    In rats, glutathione tended to increase with carnosine plus melatonin versus untreated liver ischemia-reperfusion injury.

    In plain wordsIn rats, glutathione tended to increase with carnosine plus melatonin compared with untreated liver injury.

    Outcome
    IncreaseGlutathione with combination
    Study

    ratn: not reported in source

    liver ischemia-reperfusion injury
    Comparator
    ischemia-reperfusion group
    Outcome group
    Oxidative stress · Liver

    Source sentences

    Summary
    Glutathione level was low in the ischemia-reperfusion group while it tended to increase in the ischemia-reperfusion+carnosine administered and ischemia-reperfusion+carnosine+melatonin administered groups.
    2 context sentences
    Summary · context
    Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
    Summary · context
    Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  8. 18AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome

    In rats, carnosine plus melatonin lowered apoptotic cell numbers versus untreated liver ischemia-reperfusion injury.

    In plain wordsIn rats, carnosine plus melatonin reduced apoptotic cells compared with untreated liver injury.

    Outcome
    DecreaseApoptotic cells with combination
    Study

    ratn: not reported in source

    liver ischemia-reperfusion injury
    Comparator
    ischemia-reperfusion group
    Outcome group
    Liver fat and liver function · Liver

    Source sentences

    Summary
    There was an increase in the number of apoptotic cells in the ischemia-reperfusion group while this number was lowered in the treatment groups.
    2 context sentences
    Summary · context
    Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
    Summary · context
    Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  9. 19AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome

    In rats with liver ischemia-reperfusion injury, carnosine plus melatonin yielded better outcomes than carnosine alone.

    In plain wordsIn rats, carnosine plus melatonin produced better liver injury outcomes than carnosine alone.

    Outcome
    Direction not reportedOverall outcomes with combination versus carnosine
    Study

    ratn: not reported in source

    liver ischemia-reperfusion injury
    Comparator
    carnosine alone
    Outcome group
    Liver fat and liver function · Liver

    Source sentences

    Summary
    The administration of melatonin and carnosine together yielded better outcomes compared to the sole administration of each agent.
    2 context sentences
    Summary · context
    Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
    Summary · context
    Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

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