In rats with liver ischemia-reperfusion injury, sinusoidal dilatation was less pronounced with carnosine than without treatment.
In plain wordsIn rats, carnosine reduced liver sinusoidal dilatation compared with untreated ischemia-reperfusion injury.
- Peptide
- L-carnosine
- Outcome
- DecreaseSinusoidal dilatation
- Study
ratn: not reported in source
liver ischemia-reperfusion injury- Comparator
- ischemia-reperfusion group
- Outcome group
- Liver fat and liver function · Liver
- Studied dose
- 250 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Sinusoidal dilatation, congestion and neutrophil infiltration were observed in the ischemia-reperfusion group while these symptoms were less pronounced in the treatment groups.
2 context sentences(design, population, supporting numbers)
Five study groups were formed; I. sham, II. ischemia-reperfusion, III. ischemia-reperfusion+melatonin, IV. ischemia-reperfusion+carnosine, V. ischemia-reperfusion+melatonin+carnosine.
Then 250 mg/kg carnosine and 10 mg/kg melatonin were administered intraperitoneally 30 min before ischemia and immediately after the reperfusion.