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Study · In vitro (cells) · mouse · 2008

1 result

Leptin infusion and obesity in mouse cause alterations in the hypothalamic melanocortin system.

Gout J, Sarafian D, Tirard J, Blondet A, Vigier M, Rajas F, Mithieux G, Begeot M, Naville D

Obesity (Silver Spring, Md.)12 Jun 2008Cited by 20 (Europe PMC)

PMID18551122 (opens in a new tab)DOI10.1038/oby.2008.303 (opens in a new tab)PepBankPUB-18551122
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In mouse hypothalamic GT1-7 cells, NDP-alpha-MSH treatment increased MC4-R expression.

    In plain wordsIn mouse brain cells grown in the lab, NDP-alpha-MSH raised the level of the MC4-R receptor.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseMC4-R expression in GT1-7 cells
    Study

    mousen: not reported in source

    Mouse hypothalamic GT1-7 cell line
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This hypothesis was reinforced after in vitro studies, using the mouse hypothalamic GT1-7 cell line, since both leptin and Norleucine(4), D-Phenylalanine(7)-alpha-MSH (NDP-alpha-MSH) treatments increased MC4-R expression.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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