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Study · In vitro (cells) · 2008

5 results

Thymosin beta4 is involved in stabilin-2-mediated apoptotic cell engulfment.

Lee SJ, So IS, Park SY, Kim IS

FEBS letters2 Jun 2008Cited by 40 (Europe PMC)

PMID18519035 (opens in a new tab)DOI10.1016/j.febslet.2008.03.058 (opens in a new tab)PepBankPUB-18519035
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    Thymosin beta4 interacted with the cytoplasmic domain of stabilin-2 in a yeast two-hybrid screen of a human spleen cDNA library.

    In plain wordsIn lab tests, thymosin beta4 was found to bind to part of the stabilin-2 receptor.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableInteraction with stabilin-2 cytoplasmic domain
    Study

    humann: not reported in source

    yeast two-hybrid screen of a human spleen cDNA library
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that thymosin beta4 interacts with the stabilin-2 cytoplasmic domain and is co-localized with stabilin-2 at the phagocytic cup.
  2. 02LabIn vitro (cells)Activity measurement

    Thymosin beta4 co-localized with stabilin-2 at the phagocytic cup.

    In plain wordsIn cells, thymosin beta4 was found at the same place as stabilin-2 where cells take up dead cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableCo-localization with stabilin-2 at the phagocytic cup
    Study

    humann: not reported in source

    cells expressing stabilin-2
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    is co-localized with stabilin-2 at the phagocytic cup.
  3. 03LabIn vitro (cells)Mechanism

    Amino acids 2504-2514 of the stabilin-2 cytoplasmic domain were responsible for the interaction with thymosin beta4.

    In plain wordsIn lab tests, a short stretch of stabilin-2 was found to be the part that binds thymosin beta4.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableStabilin-2 region responsible for thymosin beta4 interaction
    Study

    humann: not reported in source

    cells expressing stabilin-2
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, amino acids 2504-2514 of stabilin-2 cytoplasmic domain were found to be responsible for the interaction with thymosin beta4.

Studies that did not test the peptide alone2

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 04LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    Overexpression of thymosin beta4 increased the phagocytic activity of stabilin-2.

    In plain wordsIn cells, raising Tβ4 gene activity increased the dead-cell-eating activity of stabilin-2.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseStabilin-2 phagocytic activity with thymosin beta4 overexpression
    Study

    humann: not reported in source

    cells expressing stabilin-2
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    whereas overexpression of thymosin beta4 increased this activity.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 05LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    Knockdown of thymosin beta4 significantly decreased the phagocytic activity of stabilin-2.

    In plain wordsIn cells, removing thymosin beta4 reduced the dead-cell uptake activity of stabilin-2.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseStabilin-2 phagocytic activity with thymosin beta4 knockdown
    Study

    humann: not reported in source

    cells expressing stabilin-2
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    Knockdown of thymosin beta4 significantly decreased the phagocytic activity of stabilin-2

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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