Effects of somatostatin analog SOM230 on cell proliferation, apoptosis, and catecholamine levels in cultured pheochromocytoma cells.

Pasquali D, Rossi V, Conzo G, Pannone G, Bufo P, De Bellis A, Renzullo A, Bellastella G, Colao A, Vallone G, Bellastella A, Sinisi AA

Journal of molecular endocrinology1 Jun 2008Cited by 46 (Europe PMC)

PMID18502819DOI10.1677/jme-08-0012PepBankPUB-18502819

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In primary human pheochromocytoma cultures, pasireotide reduced cell viability after 48 h.
In plain wordsIn cells from human pheochromocytomas, pasireotide reduced cell viability after 48 hours compared with untreated cells.
Peptide
Pasireotide
Outcome
DecreaseCell viability at 48 h
Study
humann: not reported in source
primary pheochromocytoma cell cultures
Comparator
untreated cells
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated · 48 hAs given in this study (human).
Source sentences
Summary
Even if reduction of cell viability was observed in Pheo-c treated for 48 h with either OCT or SOM230 and this effect increased after 72 h
3 context sentences(design, population, supporting numbers)
Summary · context
We investigated the effects of the new somatostatin analog (pasireotide) SOM230 versus octreotide (OCT) in primary PHEO cell cultures (Pheo-c).
Summary · context
Pheo-c from six benign surgical samples were set up and characterized by immunocytochemistry.
Summary · context
Cells treated with various doses of OCT or SOM230 for 48 and 72 h were analyzed to assess their effects on cell proliferation and apoptosis and catecholamine levels.
Report a problemFND-1850281901
02LabIn vitro (cells)Activity measurement
In primary human pheochromocytoma cultures, pasireotide reduced cell viability more after 72 h than 48 h.
In plain wordsIn cells from human pheochromocytomas, pasireotide reduced cell viability more after 72 hours than 48 hours.
Peptide
Pasireotide
Outcome
DecreaseCell viability effect at 72 versus 48 h
Study
humann: not reported in source
primary pheochromocytoma cell cultures
Comparator
48 h exposure
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated · 72 hAs given in this study (human).
Source sentences
Summary
Even if reduction of cell viability was observed in Pheo-c treated for 48 h with either OCT or SOM230 and this effect increased after 72 h
3 context sentences(design, population, supporting numbers)
Summary · context
We investigated the effects of the new somatostatin analog (pasireotide) SOM230 versus octreotide (OCT) in primary PHEO cell cultures (Pheo-c).
Summary · context
Pheo-c from six benign surgical samples were set up and characterized by immunocytochemistry.
Summary · context
Cells treated with various doses of OCT or SOM230 for 48 and 72 h were analyzed to assess their effects on cell proliferation and apoptosis and catecholamine levels.
Report a problemFND-1850281902
03LabIn vitro (cells)Activity measurement
In primary human pheochromocytoma cultures, pasireotide inhibited cell growth more significantly than octreotide.
In plain wordsIn cells from human pheochromocytomas, pasireotide inhibited cell growth more significantly than octreotide.
Peptide
Pasireotide
Outcome
DecreaseCell growth versus octreotide
Study
humann: not reported in source
primary pheochromocytoma cell cultures
Comparator
octreotide
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
a more significant inhibition of cell growth as well as a significantly higher induction of apoptosis was seen in Pheo-c treated with SOM230 versus OCT.
3 context sentences(design, population, supporting numbers)
Summary · context
We investigated the effects of the new somatostatin analog (pasireotide) SOM230 versus octreotide (OCT) in primary PHEO cell cultures (Pheo-c).
Summary · context
Pheo-c from six benign surgical samples were set up and characterized by immunocytochemistry.
Summary · context
Cells treated with various doses of OCT or SOM230 for 48 and 72 h were analyzed to assess their effects on cell proliferation and apoptosis and catecholamine levels.
Report a problemFND-1850281903
04LabIn vitro (cells)Activity measurement
In primary human pheochromocytoma cultures, pasireotide induced significantly more apoptosis than octreotide.
In plain wordsIn cells from human pheochromocytomas, pasireotide induced more cell death than octreotide.
Peptide
Pasireotide
Outcome
IncreaseApoptosis versus octreotide
Study
humann: not reported in source
primary pheochromocytoma cell cultures
Comparator
octreotide
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
a more significant inhibition of cell growth as well as a significantly higher induction of apoptosis was seen in Pheo-c treated with SOM230 versus OCT.
3 context sentences(design, population, supporting numbers)
Summary · context
We investigated the effects of the new somatostatin analog (pasireotide) SOM230 versus octreotide (OCT) in primary PHEO cell cultures (Pheo-c).
Summary · context
Pheo-c from six benign surgical samples were set up and characterized by immunocytochemistry.
Summary · context
Cells treated with various doses of OCT or SOM230 for 48 and 72 h were analyzed to assess their effects on cell proliferation and apoptosis and catecholamine levels.
Report a problemFND-1850281904
05LabIn vitro (cells)Activity measurement
In primary human pheochromocytoma cultures, apoptosis was detectable after 48 h of pasireotide exposure.
In plain wordsIn cells from human pheochromocytomas, cell death was detectable after 48 hours of pasireotide exposure.
Peptide
Pasireotide
Outcome
Not applicableApoptosis at 48 h
Study
humann: not reported in source
primary pheochromocytoma cell cultures
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated · 48 hAs given in this study (human).
Source sentences
Summary
In particular, apoptosis in Pheo-c was detected after 48 h and was associated with increased expression and activation of caspase-3 and cleaved poly(ADP-ribose) polymerase.
4 context sentences(design, population, supporting numbers)
Summary · context
Even if reduction of cell viability was observed in Pheo-c treated for 48 h with either OCT or SOM230 and this effect increased after 72 h, a more significant inhibition of cell growth as well as a significantly higher induction of apoptosis was seen in Pheo-c treated with SOM230 versus OCT.
Summary · context
We investigated the effects of the new somatostatin analog (pasireotide) SOM230 versus octreotide (OCT) in primary PHEO cell cultures (Pheo-c).
Summary · context
Pheo-c from six benign surgical samples were set up and characterized by immunocytochemistry.
Summary · context
Cells treated with various doses of OCT or SOM230 for 48 and 72 h were analyzed to assess their effects on cell proliferation and apoptosis and catecholamine levels.
Report a problemFND-1850281905
06LabIn vitro (cells)Activity measurement
In primary human pheochromocytoma cultures, apoptosis after pasireotide exposure was associated with increased caspase-3 expression and activation.
In plain wordsIn cells from human pheochromocytomas, cell death after pasireotide exposure was linked to increased caspase-3 expression and activation.
Peptide
Pasireotide
Outcome
IncreaseCaspase-3 expression and activation
Study
humann: not reported in source
primary pheochromocytoma cell cultures
Outcome group
Receptor activity and mechanism · Cancer
Studied dose
Dose not stated
Source sentences
Summary
In particular, apoptosis in Pheo-c was detected after 48 h and was associated with increased expression and activation of caspase-3 and cleaved poly(ADP-ribose) polymerase.
4 context sentences(design, population, supporting numbers)
Summary · context
Even if reduction of cell viability was observed in Pheo-c treated for 48 h with either OCT or SOM230 and this effect increased after 72 h, a more significant inhibition of cell growth as well as a significantly higher induction of apoptosis was seen in Pheo-c treated with SOM230 versus OCT.
Summary · context
We investigated the effects of the new somatostatin analog (pasireotide) SOM230 versus octreotide (OCT) in primary PHEO cell cultures (Pheo-c).
Summary · context
Pheo-c from six benign surgical samples were set up and characterized by immunocytochemistry.
Summary · context
Cells treated with various doses of OCT or SOM230 for 48 and 72 h were analyzed to assess their effects on cell proliferation and apoptosis and catecholamine levels.
Report a problemFND-1850281906
07LabIn vitro (cells)Activity measurement
In primary human pheochromocytoma cultures, apoptosis after pasireotide exposure was associated with increased cleaved poly(ADP-ribose) polymerase expression and activation.
In plain wordsIn cells from human pheochromocytomas, cell death after pasireotide exposure was linked to increased cleaved PARP expression and activation.
Peptide
Pasireotide
Outcome
IncreaseCleaved PARP expression and activation
Study
humann: not reported in source
primary pheochromocytoma cell cultures
Outcome group
Receptor activity and mechanism · Cancer
Studied dose
Dose not stated
Source sentences
Summary
In particular, apoptosis in Pheo-c was detected after 48 h and was associated with increased expression and activation of caspase-3 and cleaved poly(ADP-ribose) polymerase.
4 context sentences(design, population, supporting numbers)
Summary · context
Even if reduction of cell viability was observed in Pheo-c treated for 48 h with either OCT or SOM230 and this effect increased after 72 h, a more significant inhibition of cell growth as well as a significantly higher induction of apoptosis was seen in Pheo-c treated with SOM230 versus OCT.
Summary · context
We investigated the effects of the new somatostatin analog (pasireotide) SOM230 versus octreotide (OCT) in primary PHEO cell cultures (Pheo-c).
Summary · context
Pheo-c from six benign surgical samples were set up and characterized by immunocytochemistry.
Summary · context
Cells treated with various doses of OCT or SOM230 for 48 and 72 h were analyzed to assess their effects on cell proliferation and apoptosis and catecholamine levels.
Report a problemFND-1850281907
08LabIn vitro (cells)Activity measurement
In primary human pheochromocytoma cultures, pasireotide 10(-7) M significantly reduced catecholamine levels.
In plain wordsIn cells from human pheochromocytomas, pasireotide reduced catecholamine levels compared with untreated cells.
Peptide
Pasireotide
Outcome
DecreaseCatecholamine levels
Study
humann: not reported in source
primary pheochromocytoma cell cultures
Comparator
untreated cells
Outcome group
Receptor activity and mechanism · Cancer
Studied dose
10(-7) MAs given in this study (human).
Source sentences
Summary
OCT 10(-6) M and SOM230 10(-7) M significantly reduced catecholamine levels.
3 context sentences(design, population, supporting numbers)
Summary · context
We investigated the effects of the new somatostatin analog (pasireotide) SOM230 versus octreotide (OCT) in primary PHEO cell cultures (Pheo-c).
Summary · context
Pheo-c from six benign surgical samples were set up and characterized by immunocytochemistry.
Summary · context
Cells treated with various doses of OCT or SOM230 for 48 and 72 h were analyzed to assess their effects on cell proliferation and apoptosis and catecholamine levels.
Report a problemFND-1850281908

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:34 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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