In Fischer rats given L-NAME, aortic secretion of thymosin beta4 was differentially increased, among four biomarkers linked to aortic wall hypertrophic remodeling.
In plain wordsIn rats, more of the body's own thymosin beta4 was released by the aorta in the strain with greater blood vessel remodeling.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- IncreaseAortic secretion of thymosin beta4 in L-NAME hypertension
- Study
ratn: not reported in source
Fischer rats with L-NAME induced hypertension- Comparator
- Brown Norway rats and controls
- Outcome group
- Vascular function · Cardiovascular
Source sentences
Proteomic analysis of secreted aortic proteins by SELDI-TOF MS allowed detection of four mass-to-charge ratio (m/z) peaks whose corresponding proteins were identified as ubiquitin, smooth muscle (SM) 22alpha, thymosin beta4, and C-terminal fragment of filamin A, differentially secreted in Fischer ra…
2 context sentences(design, population, supporting numbers)
The greater susceptibility of Fischer rats is associated with aortic wall hypertrophic remodeling, reflected by increased aortic secretion of four identified biomarkers.
Fischer and Brown Norway (BN) rats were divided into a control group and a group receiving low-dose N(Omega)-nitro-L-arginine methyl ester (L-NAME), a hypertensive drug, interfering with endothelial function.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.