Thymosin beta-4 upregulates anti-oxidative enzymes and protects human cornea epithelial cells against oxidative damage.

Ho JH, Tseng KC, Ma WH, Chen KH, Lee OK, Su Y

The British journal of ophthalmology14 May 2008Cited by 48 (Europe PMC)

PMID18480304DOI10.1136/bjo.2007.136747PepBankPUB-18480304

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

7 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In human cornea epithelial cells, thymosin beta‑4 reduced H2O2-induced caspase-9 activation.
In plain wordsIn cells, thymosin beta‑4 reduced a cell death signal that hydrogen peroxide caused in cornea cells.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCaspase-9 activation
Study
humann: not reported in source
HCE-T human cornea epithelial cells
Comparator
H2O2 exposure without T beta(4) pretreatment
Outcome group
Oxidative stress · Eye
Studied dose
Dose not stated
Source sentences
Summary
Besides reducing caspase-9 activation and intracellular ROS levels induced by H(2)O(2), treatment of T beta(4) could also increase cell viability and stimulate the expression of manganese superoxide dismutase (SOD) and copper/zinc SOD.
1 context sentence(design, population, supporting numbers)
Summary · context
HCE-T cells with or without T beta(4) pretreatment were exposed to H(2)O(2), and the differences in caspase activity, intracellular ROS levels, cell viability, and the expression of anti-oxidative enzymes, were measured and compared.
Report a problemFND-1848030401
02LabIn vitro (cells)Mechanism
In human cornea epithelial cells, thymosin beta‑4 reduced H2O2-induced intracellular ROS levels.
In plain wordsIn cells, thymosin beta‑4 lowered the reactive oxygen level that hydrogen peroxide caused in cornea cells.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseIntracellular ROS levels
Study
humann: not reported in source
HCE-T human cornea epithelial cells
Comparator
H2O2 exposure without T beta(4) pretreatment
Outcome group
Oxidative stress · Eye
Studied dose
Dose not stated
Source sentences
Summary
Besides reducing caspase-9 activation and intracellular ROS levels induced by H(2)O(2), treatment of T beta(4) could also increase cell viability and stimulate the expression of manganese superoxide dismutase (SOD) and copper/zinc SOD.
1 context sentence(design, population, supporting numbers)
Summary · context
HCE-T cells with or without T beta(4) pretreatment were exposed to H(2)O(2), and the differences in caspase activity, intracellular ROS levels, cell viability, and the expression of anti-oxidative enzymes, were measured and compared.
Report a problemFND-1848030402
03LabIn vitro (cells)Efficacy outcome
In human cornea epithelial cells exposed to H2O2, thymosin beta‑4 increased cell viability.
In plain wordsIn cells, thymosin beta‑4 raised the survival of cornea cells exposed to hydrogen peroxide.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCell viability
Study
humann: not reported in source
HCE-T human cornea epithelial cells
Comparator
H2O2 exposure without T beta(4) pretreatment
Outcome group
Oxidative stress · Eye
Studied dose
Dose not stated
Source sentences
Summary
Besides reducing caspase-9 activation and intracellular ROS levels induced by H(2)O(2), treatment of T beta(4) could also increase cell viability and stimulate the expression of manganese superoxide dismutase (SOD) and copper/zinc SOD.
1 context sentence(design, population, supporting numbers)
Summary · context
HCE-T cells with or without T beta(4) pretreatment were exposed to H(2)O(2), and the differences in caspase activity, intracellular ROS levels, cell viability, and the expression of anti-oxidative enzymes, were measured and compared.
Report a problemFND-1848030403
04LabIn vitro (cells)Mechanism
In human cornea epithelial cells, thymosin beta‑4 stimulated the expression of manganese superoxide dismutase.
In plain wordsIn cells, thymosin beta‑4 raised an antioxidant enzyme, manganese SOD, in cornea cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseManganese SOD expression
Study
humann: not reported in source
HCE-T human cornea epithelial cells
Comparator
H2O2 exposure without T beta(4) pretreatment
Outcome group
Oxidative stress · Eye
Studied dose
Dose not stated
Source sentences
Summary
Besides reducing caspase-9 activation and intracellular ROS levels induced by H(2)O(2), treatment of T beta(4) could also increase cell viability and stimulate the expression of manganese superoxide dismutase (SOD) and copper/zinc SOD.
1 context sentence(design, population, supporting numbers)
Summary · context
HCE-T cells with or without T beta(4) pretreatment were exposed to H(2)O(2), and the differences in caspase activity, intracellular ROS levels, cell viability, and the expression of anti-oxidative enzymes, were measured and compared.
Report a problemFND-1848030404
05LabIn vitro (cells)Mechanism
In human cornea epithelial cells, thymosin beta‑4 stimulated the expression of copper/zinc superoxide dismutase.
In plain wordsIn cells, thymosin beta‑4 raised an antioxidant enzyme, copper/zinc SOD, in cornea cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCopper/zinc SOD expression
Study
humann: not reported in source
HCE-T human cornea epithelial cells
Comparator
H2O2 exposure without T beta(4) pretreatment
Outcome group
Oxidative stress · Eye
Studied dose
Dose not stated
Source sentences
Summary
Besides reducing caspase-9 activation and intracellular ROS levels induced by H(2)O(2), treatment of T beta(4) could also increase cell viability and stimulate the expression of manganese superoxide dismutase (SOD) and copper/zinc SOD.
1 context sentence(design, population, supporting numbers)
Summary · context
HCE-T cells with or without T beta(4) pretreatment were exposed to H(2)O(2), and the differences in caspase activity, intracellular ROS levels, cell viability, and the expression of anti-oxidative enzymes, were measured and compared.
Report a problemFND-1848030405
06LabIn vitro (cells)Mechanism
In human cornea epithelial cells exposed to exogenous H2O2, thymosin beta‑4 upregulated catalase transcription.
In plain wordsIn cells, thymosin beta‑4 raised catalase gene activity in cornea cells exposed to hydrogen peroxide.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCatalase transcription
Study
humann: not reported in source
HCE-T human cornea epithelial cells
Comparator
H2O2 exposure without T beta(4) pretreatment
Outcome group
Oxidative stress · Eye
Studied dose
Dose not stated
Source sentences
Summary
Moreover, both transcription and translation levels of catalase were also upregulated by T beta(4) in the presence of exogenous H(2)O(2).
1 context sentence(design, population, supporting numbers)
Summary · context
HCE-T cells with or without T beta(4) pretreatment were exposed to H(2)O(2), and the differences in caspase activity, intracellular ROS levels, cell viability, and the expression of anti-oxidative enzymes, were measured and compared.
Report a problemFND-1848030406
07LabIn vitro (cells)Mechanism
In human cornea epithelial cells exposed to exogenous H2O2, thymosin beta‑4 upregulated catalase translation.
In plain wordsIn cells, thymosin beta‑4 raised catalase protein in cornea cells exposed to hydrogen peroxide.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCatalase translation
Study
humann: not reported in source
HCE-T human cornea epithelial cells
Comparator
H2O2 exposure without T beta(4) pretreatment
Outcome group
Oxidative stress · Eye
Studied dose
Dose not stated
Source sentences
Summary
Moreover, both transcription and translation levels of catalase were also upregulated by T beta(4) in the presence of exogenous H(2)O(2).
1 context sentence(design, population, supporting numbers)
Summary · context
HCE-T cells with or without T beta(4) pretreatment were exposed to H(2)O(2), and the differences in caspase activity, intracellular ROS levels, cell viability, and the expression of anti-oxidative enzymes, were measured and compared.
Report a problemFND-1848030407

Studies that did not test the peptide alone1

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

08LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In human cornea epithelial cells, a catalase inhibitor abrogated the protective effect of thymosin beta‑4 against H2O2-induced oxidative damage.
In plain wordsIn cells, blocking catalase removed the protection that thymosin beta‑4 gave against hydrogen peroxide damage.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseProtective effect of T beta(4) with catalase inhibitor
Study
humann: not reported in source
HCE-T human cornea epithelial cells
Comparator
T beta(4) without catalase inhibitor
Outcome group
Oxidative stress · Eye
Source sentences
Summary
Furthermore, it was demonstrated that the addition of catalase inhibitor abrogated the protective effect of T beta(4) against H(2)O(2)-induced oxidative damage.
1 context sentence(design, population, supporting numbers)
Summary · context
HCE-T cells with or without T beta(4) pretreatment were exposed to H(2)O(2), and the differences in caspase activity, intracellular ROS levels, cell viability, and the expression of anti-oxidative enzymes, were measured and compared.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-1848030408

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

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