In uraemic T-lymphocytes, the [1-Nal(12)] analog restored the impaired blastogenic response more strongly than deacetyl-thymosin beta‑4 and slightly less than the [Phe(4F)(12)] analog.
In plain wordsIn cells, an analog of thymosin beta‑4 restored impaired T-cell response more strongly than deacetyl-thymosin beta‑4.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- IncreaseRestorative effect of [1-Nal(12)] analog on blastogenic response
- Study
n: not reported in source
Uraemic T-lymphocytes- Comparator
- Deacetyl-thymosin beta 4
- Outcome group
- Immune response · Immune and inflammation
Source sentences
The results indicated that [1-Nal(12)]deacetyl-thymosin beta(4) which had a bulky naphthyl ring showed a stronger restorative effect than that of deacetyl-thymosin beta(4), but it was slightly weaker than that of [Phe(4F)(12)]deacetyl-thymosin beta(4).
1 context sentence(design, population, supporting numbers)
In order to evaluate the functional roles of this phenyl group in the restorative effect on impaired T-lymphocytes, two analogues, [1- Nal(12)]deacetyl-thymosin beta(4) and [Cha(12)]deacetyl4 thymosin beta(4), were synthesized by a solid-phase method and evaluated for restorative effect on the impaired blastogenic response of uraemic T-lymphocytes.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).