The promotive effects of thymosin beta4 on neuronal survival and neurite outgrowth by upregulating L1 expression.

Yang H, Cheng X, Yao Q, Li J, Ju G

Neurochemical research7 May 2008Cited by 60 (Europe PMC)

PMID18461449DOI10.1007/s11064-008-9712-yPepBankPUB-18461449

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In cultured mouse spinal cord neurons, thymosin beta4 increased L1 mRNA expression dose-dependently, with a rise of more than 2.1-fold at the highest level.
In plain wordsIn mouse nerve cells in a dish, thymosin beta4 raised L1 mRNA in a dose-dependent way.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseL1 mRNA expression
Study
mousen: not reported in source
primary cultured spinal cord neurons
Comparator
Cultures without Tbeta4
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.1 to 10 microg/mlAs given in this study (mouse).
Measurements
L1 mRNA increase
> 2.1 fold
highest Tbeta4 concentration
Source sentences
Summary
We found that Tbeta4 enhanced L1 expression in a dose-dependent manner, and the highest L1 mRNA and protein synthesis in cells increased by more than 2.1- and 2.3-fold in the presence of Tbeta4 at identical concentrations, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
To test this hypothesis, primarily cultured neurons were prepared from the mouse spinal cord and treated with various concentrations of Tbeta4 ranging from 0.1 to 10 microg/ml.
Report a problemFND-1846144901
02LabIn vitro (cells)Mechanism
In cultured mouse spinal cord neurons, thymosin beta4 increased L1 protein synthesis dose-dependently, with a rise of more than 2.3-fold at the highest level.
In plain wordsIn mouse nerve cells in a dish, thymosin beta4 raised L1 protein in a dose-dependent way.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseL1 protein synthesis
Study
mousen: not reported in source
primary cultured spinal cord neurons
Comparator
Cultures without Tbeta4
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.1 to 10 microg/mlAs given in this study (mouse).
Measurements
L1 protein increase
> 2.3 fold
highest Tbeta4 concentration
Source sentences
Summary
We found that Tbeta4 enhanced L1 expression in a dose-dependent manner, and the highest L1 mRNA and protein synthesis in cells increased by more than 2.1- and 2.3-fold in the presence of Tbeta4 at identical concentrations, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
To test this hypothesis, primarily cultured neurons were prepared from the mouse spinal cord and treated with various concentrations of Tbeta4 ranging from 0.1 to 10 microg/ml.
Report a problemFND-1846144902
03LabIn vitro (cells)Efficacy outcome
In cultured mouse spinal cord neurons, thymosin beta4 dose-dependently enhanced neurite outgrowth, and neurite length increased markedly at 0.5, 1 and 5 microg/ml.
In plain wordsIn mouse nerve cells in a dish, thymosin beta4 made nerve fibres grow longer in a dose-dependent way.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseNeurite outgrowth
Study
mousen: not reported in source
primary cultured spinal cord neurons
Comparator
Cultures without Tbeta4
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.1 to 10 microg/mlAs given in this study (mouse).
Source sentences
Summary
Moreover, it also dose dependently enhanced neurite outgrowth and neuronal survival.
2 context sentences(design, population, supporting numbers)
Summary · context
Compared to conditions without Tbeta4, the length of neurite and neuronal survival increased markedly in presence of 0.5, 1, and 5 microg/ml Tbeta4, respectively, whereas the effects of Tbeta4 were significantly attenuated or inhibited in the process of L1-Fc antibodies treatment.
Summary · context
To test this hypothesis, primarily cultured neurons were prepared from the mouse spinal cord and treated with various concentrations of Tbeta4 ranging from 0.1 to 10 microg/ml.
Report a problemFND-1846144903
04LabIn vitro (cells)Efficacy outcome
In cultured mouse spinal cord neurons, thymosin beta4 dose-dependently enhanced neuronal survival, which increased markedly at 0.5, 1 and 5 microg/ml.
In plain wordsIn mouse nerve cells in a dish, thymosin beta4 raised nerve cell survival in a dose-dependent way.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseNeuronal survival
Study
mousen: not reported in source
primary cultured spinal cord neurons
Comparator
Cultures without Tbeta4
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.1 to 10 microg/mlAs given in this study (mouse).
Source sentences
Summary
Moreover, it also dose dependently enhanced neurite outgrowth and neuronal survival.
2 context sentences(design, population, supporting numbers)
Summary · context
Compared to conditions without Tbeta4, the length of neurite and neuronal survival increased markedly in presence of 0.5, 1, and 5 microg/ml Tbeta4, respectively, whereas the effects of Tbeta4 were significantly attenuated or inhibited in the process of L1-Fc antibodies treatment.
Summary · context
To test this hypothesis, primarily cultured neurons were prepared from the mouse spinal cord and treated with various concentrations of Tbeta4 ranging from 0.1 to 10 microg/ml.
Report a problemFND-1846144904
05LabIn vitro (cells)Mechanism
In cultured mouse spinal cord neurons, the effects of thymosin beta4 on neurite length and survival were significantly attenuated or inhibited by L1-Fc antibody treatment.
In plain wordsIn mouse nerve cells in a dish, blocking L1 with antibodies weakened or stopped the effects of thymosin beta4.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseThymosin beta4 effects with L1-Fc antibody
Study
mousen: not reported in source
primary cultured spinal cord neurons
Comparator
Tbeta4 without L1-Fc antibodies
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
0.1 to 10 microg/mlAs given in this study (mouse).
Source sentences
Summary
whereas the effects of Tbeta4 were significantly attenuated or inhibited in the process of L1-Fc antibodies treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
To test this hypothesis, primarily cultured neurons were prepared from the mouse spinal cord and treated with various concentrations of Tbeta4 ranging from 0.1 to 10 microg/ml.
Report a problemFND-1846144905

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

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