Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states.

Roa J, Vigo E, García-Galiano D, Castellano JM, Navarro VM, Pineda R, Diéguez C, Aguilar E, Pinilla L, Tena-Sempere M

American journal of physiology. Endocrinology and metabolism15 Apr 2008Cited by 78 (Europe PMC)

PMID18413669DOI10.1152/ajpendo.90240.2008PepBankPUB-18413669

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In adult female rats, continuous kisspeptin‑10 infusion caused a transient rise in serum LH, then a sharp drop and return to normal levels.
In plain wordsIn adult female rats, continuous kisspeptin‑10 briefly raised LH, then LH dropped back to normal.
Peptide
Kisspeptin-10
Outcome
MixedSerum LH during continuous kisspeptin-10 infusion in adult females
Study
ratn: not reported in source
in vivo
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · continuous intracerebral infusionAs given in this study (rat).
Source sentences
Summary
Infusion of kisspeptin-10 to adult female rats induced a transient elevation in serum LH concentrations, followed by a precipitous drop and normalization of LH levels thereafter.
1 context sentence(design, population, supporting numbers)
Summary · context
We report herein LH and FSH responses to continuous intracerebral administration of kisspeptin in female rats at different developmental and metabolic states.
Report a problemFND-1841366901
02AnimalAnimal study (in vivo)Efficacy outcome
In underfed adult female rats, the LH rise after kisspeptin infusion lasted longer; leptin administration mimicked this.
In plain wordsIn underfed female rats, the LH rise after kisspeptin lasted longer, and leptin had a similar effect.
Peptide
Kisspeptin-10
Outcome
IncreaseDuration of LH elevation in underfed rats
Study
ratn: not reported in source
in vivo
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · continuous intracerebral infusionAs given in this study (rat).
Source sentences
Summary
Elevation of LH after kisspeptin infusion was prolonged in underfed animals; a phenomenon mimicked by leptin administration.
1 context sentence(design, population, supporting numbers)
Summary · context
We report herein LH and FSH responses to continuous intracerebral administration of kisspeptin in female rats at different developmental and metabolic states.
Report a problemFND-1841366902
03AnimalAnimal study (in vivo)Efficacy outcome
In adult female rats, FSH levels stayed raised throughout continuous kisspeptin infusion.
In plain wordsIn adult female rats, FSH stayed high during continuous kisspeptin infusion.
Peptide
Kisspeptin-10
Outcome
IncreaseSerum FSH during continuous kisspeptin infusion
Study
ratn: not reported in source
in vivo
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · continuous intracerebral infusionAs given in this study (rat).
Source sentences
Summary
Conversely, FSH levels were persistently heightened along continuous kisspeptin infusion, but duration of this response was shortened by undernutrition.
1 context sentence(design, population, supporting numbers)
Summary · context
We report herein LH and FSH responses to continuous intracerebral administration of kisspeptin in female rats at different developmental and metabolic states.
Report a problemFND-1841366903
04AnimalAnimal study (in vivo)Efficacy outcome
In undernourished adult female rats, the FSH response to continuous kisspeptin infusion was shorter.
In plain wordsIn undernourished female rats, the FSH rise during kisspeptin infusion was shorter.
Peptide
Kisspeptin-10
Outcome
DecreaseDuration of FSH elevation in undernourished rats
Study
ratn: not reported in source
in vivo
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · continuous intracerebral infusionAs given in this study (rat).
Source sentences
Summary
Conversely, FSH levels were persistently heightened along continuous kisspeptin infusion, but duration of this response was shortened by undernutrition.
1 context sentence(design, population, supporting numbers)
Summary · context
We report herein LH and FSH responses to continuous intracerebral administration of kisspeptin in female rats at different developmental and metabolic states.
Report a problemFND-1841366904
05AnimalAnimal study (in vivo)Efficacy outcome
In pubertal female rats, LH levels were still raised at the end of a 7-day kisspeptin infusion.
In plain wordsIn pubertal female rats, LH was still high after 7 days of kisspeptin infusion.
Peptide
Kisspeptin-10
Outcome
IncreaseLH after 7-day kisspeptin infusion in pubertal females
Study
ratn: not reported in source
in vivo
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · continuous intracerebral infusion · 7 daysAs given in this study (rat).
Source sentences
Summary
In pubertal females, LH and FSH levels remained elevated at the end of a 7-day infusion of kisspeptin; responses whose magnitude was augmented by subnutrition but not mimicked by leptin.
1 context sentence(design, population, supporting numbers)
Summary · context
We report herein LH and FSH responses to continuous intracerebral administration of kisspeptin in female rats at different developmental and metabolic states.
Report a problemFND-1841366905
06AnimalAnimal study (in vivo)Efficacy outcome
In pubertal female rats, FSH levels were still raised at the end of a 7-day kisspeptin infusion.
In plain wordsIn pubertal female rats, FSH was still high after 7 days of kisspeptin infusion.
Peptide
Kisspeptin-10
Outcome
IncreaseFSH after 7-day kisspeptin infusion in pubertal females
Study
ratn: not reported in source
in vivo
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · continuous intracerebral infusion · 7 daysAs given in this study (rat).
Source sentences
Summary
In pubertal females, LH and FSH levels remained elevated at the end of a 7-day infusion of kisspeptin; responses whose magnitude was augmented by subnutrition but not mimicked by leptin.
1 context sentence(design, population, supporting numbers)
Summary · context
We report herein LH and FSH responses to continuous intracerebral administration of kisspeptin in female rats at different developmental and metabolic states.
Report a problemFND-1841366906
07AnimalAnimal study (in vivo)Efficacy outcome
In pubertal female rats, subnutrition increased the size of the LH and FSH response to kisspeptin; leptin did not mimic this.
In plain wordsIn pubertal female rats on low food, the LH and FSH rise to kisspeptin was larger, and leptin did not copy this.
Peptide
Kisspeptin-10
Outcome
IncreaseSize of LH and FSH response in subnourished pubertal females
Study
ratn: not reported in source
in vivo
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · continuous intracerebral infusion · 7 daysAs given in this study (rat).
Source sentences
Summary
In pubertal females, LH and FSH levels remained elevated at the end of a 7-day infusion of kisspeptin; responses whose magnitude was augmented by subnutrition but not mimicked by leptin.
1 context sentence(design, population, supporting numbers)
Summary · context
We report herein LH and FSH responses to continuous intracerebral administration of kisspeptin in female rats at different developmental and metabolic states.
Report a problemFND-1841366907
08AnimalAnimal study (in vivo)Efficacy outcome
In female rats at all developmental and metabolic states studied, GnRH responses after kisspeptin infusion were fully preserved.
In plain wordsIn female rats, the response to GnRH after kisspeptin infusion stayed fully intact in all settings.
Peptide
Kisspeptin-10
Outcome
No significant changeTerminal GnRH-induced gonadotropin response
Study
ratn: not reported in source
in vivo
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · continuous intracerebral infusionAs given in this study (rat).
Source sentences
Summary
In all settings, terminal gonadotropin-releasing hormone responses were fully preserved, suggesting that eventual desensitization must occur upstream from the pituitary.
1 context sentence(design, population, supporting numbers)
Summary · context
We report herein LH and FSH responses to continuous intracerebral administration of kisspeptin in female rats at different developmental and metabolic states.
Report a problemFND-1841366908

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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