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Study · Randomized controlled trial · 2009

9 results

Estrogen suppression in premenopausal women following 8 weeks of treatment with exemestane and triptorelin versus triptorelin alone.

Jannuzzo MG, Di Salle E, Spinelli R, Pirotta N, Buchan P, Bello A

Breast cancer research and treatment11 Mar 2008Cited by 17 (Europe PMC)

PMID18330698 (opens in a new tab)DOI10.1007/s10549-008-9949-9 (opens in a new tab)PepBankPUB-18330698
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanRandomized controlled trialSafety outcome

    In healthy premenopausal women, triptorelin alone was well tolerated.

    In plain wordsIn healthy premenopausal women, triptorelin alone was well tolerated.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Not applicableTriptorelin tolerability
    Study

    n: not reported in source

    Analysis
    Secondary
    Outcome group
    Adverse events · Whole body
    Studied dose
    3.75 mg on days 1 and 29 · 8 weeksAs given in this study (human).

    Source sentences

    Summary
    Both treatments were well tolerated.
    1 context sentence
    Summary · context
    Healthy premenopausal women were randomized to receive 3.75 mg triptorelin (T) on days 1 and 29 with 25 mg exemestane (EX) or matched placebo once daily for 8 weeks, from day 1 to day 56.

Studies that did not test the peptide alone8

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  1. 02HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome

    In healthy premenopausal women, triptorelin plus exemestane reduced estradiol AUC more than triptorelin alone.

    In plain wordsIn healthy premenopausal women, triptorelin plus exemestane reduced estradiol exposure more than triptorelin alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseEstradiol AUC
    Study

    n = 28

    Comparator
    Triptorelin alone
    Analysis
    Primary
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Measurements

    Estradiol AUC
    20.6 pg d/ml
    triptorelin plus exemestane
    Estradiol AUC
    54 pg d/ml
    triptorelin alone
    Estradiol AUC relative difference
    −62%
    triptorelin plus exemestane vs triptorelin alone

    Source sentences

    Summary
    Mean plasma estrogen levels (AUC(day 36-57)) were significantly lower for subjects who received T + EX than for subjects who received T alone (20.6 vs. 54.0 pg d/ml [-62%; P < 0.05], and 38.9 vs. 198.0 pg d/ml [-80%; P < 0.01] for E(2) and E(1), respectively).
    1 context sentence
    Summary · context
    Healthy premenopausal women were randomized to receive 3.75 mg triptorelin (T) on days 1 and 29 with 25 mg exemestane (EX) or matched placebo once daily for 8 weeks, from day 1 to day 56.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  2. 03HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome

    In healthy premenopausal women, triptorelin plus exemestane reduced estrone AUC more than triptorelin alone.

    In plain wordsIn healthy premenopausal women, triptorelin plus exemestane reduced estrone exposure more than triptorelin alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseEstrone AUC
    Study

    n = 28

    Comparator
    Triptorelin alone
    Analysis
    Secondary
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Measurements

    Estrone AUC
    38.9 pg d/ml
    triptorelin plus exemestane
    Estrone AUC
    198 pg d/ml
    triptorelin alone
    Estrone AUC relative difference
    −80%
    triptorelin plus exemestane vs triptorelin alone

    Source sentences

    Summary
    Mean plasma estrogen levels (AUC(day 36-57)) were significantly lower for subjects who received T + EX than for subjects who received T alone (20.6 vs. 54.0 pg d/ml [-62%; P < 0.05], and 38.9 vs. 198.0 pg d/ml [-80%; P < 0.01] for E(2) and E(1), respectively).
    1 context sentence
    Summary · context
    Healthy premenopausal women were randomized to receive 3.75 mg triptorelin (T) on days 1 and 29 with 25 mg exemestane (EX) or matched placebo once daily for 8 weeks, from day 1 to day 56.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  3. 04HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialMechanism

    In healthy premenopausal women, adding exemestane to triptorelin did not affect the initial LH flare versus triptorelin alone.

    In plain wordsIn healthy premenopausal women, adding exemestane to triptorelin did not affect the initial LH rise versus triptorelin alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeInitial LH flare
    Study

    n = 28

    Comparator
    Triptorelin alone
    Analysis
    Secondary
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Coadministration of EX did not affect the initial flare or subsequent suppression of LH and FSH following the first dose of T, or the PK of T.
    1 context sentence
    Summary · context
    Healthy premenopausal women were randomized to receive 3.75 mg triptorelin (T) on days 1 and 29 with 25 mg exemestane (EX) or matched placebo once daily for 8 weeks, from day 1 to day 56.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  4. 05HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialMechanism

    In healthy premenopausal women, adding exemestane to triptorelin did not affect the initial FSH flare versus triptorelin alone.

    In plain wordsIn healthy premenopausal women, adding exemestane to triptorelin did not affect the initial FSH rise versus triptorelin alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeInitial FSH flare
    Study

    n = 28

    Comparator
    Triptorelin alone
    Analysis
    Secondary
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Coadministration of EX did not affect the initial flare or subsequent suppression of LH and FSH following the first dose of T, or the PK of T.
    1 context sentence
    Summary · context
    Healthy premenopausal women were randomized to receive 3.75 mg triptorelin (T) on days 1 and 29 with 25 mg exemestane (EX) or matched placebo once daily for 8 weeks, from day 1 to day 56.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  5. 06HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome

    In healthy premenopausal women, adding exemestane to triptorelin did not affect subsequent LH suppression versus triptorelin alone.

    In plain wordsIn healthy premenopausal women, adding exemestane to triptorelin did not affect subsequent LH suppression versus triptorelin alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeSubsequent LH suppression
    Study

    n = 28

    Comparator
    Triptorelin alone
    Analysis
    Secondary
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Coadministration of EX did not affect the initial flare or subsequent suppression of LH and FSH following the first dose of T, or the PK of T.
    1 context sentence
    Summary · context
    Healthy premenopausal women were randomized to receive 3.75 mg triptorelin (T) on days 1 and 29 with 25 mg exemestane (EX) or matched placebo once daily for 8 weeks, from day 1 to day 56.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  6. 07HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome

    In healthy premenopausal women, adding exemestane to triptorelin did not affect subsequent FSH suppression versus triptorelin alone.

    In plain wordsIn healthy premenopausal women, adding exemestane to triptorelin did not affect subsequent FSH suppression versus triptorelin alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeSubsequent FSH suppression
    Study

    n = 28

    Comparator
    Triptorelin alone
    Analysis
    Secondary
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Coadministration of EX did not affect the initial flare or subsequent suppression of LH and FSH following the first dose of T, or the PK of T.
    1 context sentence
    Summary · context
    Healthy premenopausal women were randomized to receive 3.75 mg triptorelin (T) on days 1 and 29 with 25 mg exemestane (EX) or matched placebo once daily for 8 weeks, from day 1 to day 56.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  7. 08HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialPharmacokinetics

    In healthy premenopausal women, adding exemestane did not affect triptorelin pharmacokinetics compared with triptorelin alone.

    In plain wordsIn healthy premenopausal women, adding exemestane did not affect triptorelin processing in the body compared with triptorelin alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeTriptorelin pharmacokinetics
    Study

    n = 28

    Comparator
    Triptorelin alone
    Analysis
    Secondary
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Coadministration of EX did not affect the initial flare or subsequent suppression of LH and FSH following the first dose of T, or the PK of T.
    1 context sentence
    Summary · context
    Healthy premenopausal women were randomized to receive 3.75 mg triptorelin (T) on days 1 and 29 with 25 mg exemestane (EX) or matched placebo once daily for 8 weeks, from day 1 to day 56.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  8. 09HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialSafety outcome

    In healthy premenopausal women, triptorelin plus exemestane was well tolerated.

    In plain wordsIn healthy premenopausal women, triptorelin plus exemestane was well tolerated.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Not applicableCombination tolerability
    Study

    n: not reported in source

    Analysis
    Secondary
    Outcome group
    Adverse events · Whole body

    Source sentences

    Summary
    Both treatments were well tolerated.
    1 context sentence
    Summary · context
    Healthy premenopausal women were randomized to receive 3.75 mg triptorelin (T) on days 1 and 29 with 25 mg exemestane (EX) or matched placebo once daily for 8 weeks, from day 1 to day 56.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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