Actin-sequestering protein, thymosin-beta-4 (TB4), inhibits caspase-3 activation in paclitaxel-induced tumor cell death.

Moon EY, Song JH, Yang KH

Oncology research1 Jan 2007Cited by 19 (Europe PMC)

PMID18306930DOI10.3727/096504007783438349PepBankPUB-18306930

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

4 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In tumor cells treated with paclitaxel, TB4 peptides increased cell survival.
In plain wordsIn tumor cells, TB4 peptides raised cell survival during paclitaxel treatment.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCell survival with TB4 peptides after paclitaxel
Study
humann: not reported in source
HeLa cells and gastric tumor cell lines with paclitaxel
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Cell survival rate was increased and caspase-3 activity was decreased by the treatment with TB4 peptides.
1 context sentence(design, population, supporting numbers)
Summary · context
Here we investigated the inhibitory effect of TB4 peptides on tumor cell death by paclitaxel. The effect of TB4 peptides was assayed by the measurement of caspase-3 activity, G2/M arrest, and Bcl-2 phosphorylation.
Report a problemFND-1830693001
02LabIn vitro (cells)Mechanism
In tumor cells treated with paclitaxel, TB4 peptides decreased caspase-3 activity.
In plain wordsIn tumor cells, TB4 peptides lowered caspase-3 activity during paclitaxel treatment.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCaspase-3 activity with TB4 peptides
Study
humann: not reported in source
HeLa cells and gastric tumor cell lines with paclitaxel
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Cell survival rate was increased and caspase-3 activity was decreased by the treatment with TB4 peptides.
1 context sentence(design, population, supporting numbers)
Summary · context
Here we investigated the inhibitory effect of TB4 peptides on tumor cell death by paclitaxel. The effect of TB4 peptides was assayed by the measurement of caspase-3 activity, G2/M arrest, and Bcl-2 phosphorylation.
Report a problemFND-1830693002
03LabIn vitro (cells)Mechanism
In tumor cells, TB4 peptide treatment reduced the population in the G2/M phase.
In plain wordsIn tumor cells, TB4 peptide treatment reduced the share of cells in the G2/M phase.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseG2/M phase cell population with TB4 peptide
Study
humann: not reported in source
HeLa cells and gastric tumor cell lines with paclitaxel
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
The reduced population in G2/M phase by TB4 peptide treatment was correlated with the decreased expression of cyclin B1.
1 context sentence(design, population, supporting numbers)
Summary · context
Here we investigated the inhibitory effect of TB4 peptides on tumor cell death by paclitaxel. The effect of TB4 peptides was assayed by the measurement of caspase-3 activity, G2/M arrest, and Bcl-2 phosphorylation.
Report a problemFND-1830693006
04LabIn vitro (cells)Mechanism
In tumor cells, TB4 peptide treatment decreased cyclin B1 expression.
In plain wordsIn tumor cells, TB4 peptide treatment lowered cyclin B1 levels.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCyclin B1 expression with TB4 peptide
Study
humann: not reported in source
HeLa cells and gastric tumor cell lines with paclitaxel
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
The reduced population in G2/M phase by TB4 peptide treatment was correlated with the decreased expression of cyclin B1.
1 context sentence(design, population, supporting numbers)
Summary · context
Here we investigated the inhibitory effect of TB4 peptides on tumor cell death by paclitaxel. The effect of TB4 peptides was assayed by the measurement of caspase-3 activity, G2/M arrest, and Bcl-2 phosphorylation.
Report a problemFND-1830693007

Studies that did not test the peptide alone3

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

05LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In tumor cells, siRNA against TB4 inhibited cell viability.
In plain wordsIn tumor cells, blocking the cells' own TB4 with siRNA lowered cell viability.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCell viability after TB4 siRNA
Study
humann: not reported in source
HeLa cells and gastric tumor cell lines with paclitaxel
Outcome group
Tumor growth · Cancer
Source sentences
Summary
In contrast, small interfering RNA (siRNA) of TB4 inhibited cell viability and augmented caspase-3 activity.
1 context sentence(design, population, supporting numbers)
Summary · context
Here we investigated the inhibitory effect of TB4 peptides on tumor cell death by paclitaxel. The effect of TB4 peptides was assayed by the measurement of caspase-3 activity, G2/M arrest, and Bcl-2 phosphorylation.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-1830693003
06LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In tumor cells, siRNA against TB4 augmented caspase-3 activity.
In plain wordsIn tumor cells, blocking the cells' own TB4 with siRNA raised caspase-3 activity.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCaspase-3 activity after TB4 siRNA
Study
humann: not reported in source
HeLa cells and gastric tumor cell lines with paclitaxel
Outcome group
Tumor growth · Cancer
Source sentences
Summary
In contrast, small interfering RNA (siRNA) of TB4 inhibited cell viability and augmented caspase-3 activity.
1 context sentence(design, population, supporting numbers)
Summary · context
Here we investigated the inhibitory effect of TB4 peptides on tumor cell death by paclitaxel. The effect of TB4 peptides was assayed by the measurement of caspase-3 activity, G2/M arrest, and Bcl-2 phosphorylation.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-1830693004
07LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In HeLa cells, TB4 peptide treatment or TB4 gene overexpression caused significant changes in Bcl-2 phosphorylation.
In plain wordsIn HeLa cells, Tβ4 peptide or raised Tβ4 gene activity changed Bcl-2 phosphorylation. The direction is not stated.
Peptide
Thymosin beta-4 (human)
Outcome
Direction not reportedBcl-2 phosphorylation with TB4 peptide or TB4 overexpression
Study
humann: not reported in source
HeLa cells and gastric tumor cell lines with paclitaxel
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Significant changes in Bcl-2 phosphorylation were detected by TB4 peptide treatment or by the overexpression of TB4 gene in Hela cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Here we investigated the inhibitory effect of TB4 peptides on tumor cell death by paclitaxel. The effect of TB4 peptides was assayed by the measurement of caspase-3 activity, G2/M arrest, and Bcl-2 phosphorylation.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-1830693005

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.