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Study · In vitro (cells) · 2008

2 results

LHRH receptor targeted therapy for breast cancer.

Kakar SS, Jin H, Hong B, Eaton JW, Kang KA

Advances in experimental medicine and biology1 Jan 2008Cited by 18 (Europe PMC)

PMID18290339 (opens in a new tab)DOI10.1007/978-0-387-74911-2_32 (opens in a new tab)PepBankPUB-18290339
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In breast tumor cell lines, native triptorelin did not change cell proliferation.

    In plain wordsIn cells from breast tumors, native triptorelin did not change cell growth.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeCell proliferation
    Study

    humann: not reported in source

    MCF-7 and MDA-MB231 breast tumor cell lines
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    whereas no change in cell proliferation or cell apoptosis was observed in cells treated with equal amounts of either [D-Trp6]LHRH or unconjugated Fe3O4 nanoparticles.
    2 context sentences
    Summary · context
    Treatment of two separate breast tumor cell lines (MCF-7 and MDA-MB231)
    Summary · context
    In our studies, we conjugated Fe3O4 nanoparticles (20-30 nm) with [D-Trp6]LHRH (Triptorelin), a decapeptide analog of LHRH currently used for treatment of sex-hormone-dependent tumors.
  2. 02LabIn vitro (cells)Efficacy outcome

    In breast tumor cell lines, native triptorelin did not change cell apoptosis.

    In plain wordsIn cells from breast tumors, native triptorelin did not change programmed cell death.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeCell apoptosis
    Study

    humann: not reported in source

    MCF-7 and MDA-MB231 breast tumor cell lines
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    whereas no change in cell proliferation or cell apoptosis was observed in cells treated with equal amounts of either [D-Trp6]LHRH or unconjugated Fe3O4 nanoparticles.
    2 context sentences
    Summary · context
    Treatment of two separate breast tumor cell lines (MCF-7 and MDA-MB231)
    Summary · context
    In our studies, we conjugated Fe3O4 nanoparticles (20-30 nm) with [D-Trp6]LHRH (Triptorelin), a decapeptide analog of LHRH currently used for treatment of sex-hormone-dependent tumors.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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