Skip to content

Study · In vitro (cells) · rat · 2008

4 results

Protective effects of tetramethylpyrazine on rat retinal cell cultures.

Yang Z, Zhang Q, Ge J, Tan Z

Neurochemistry international27 Dec 2007Cited by 40 (Europe PMC)

PMID18261827 (opens in a new tab)PMCIDPMC2675694 (opens in a new tab)DOI10.1016/j.neuint.2007.12.008 (opens in a new tab)PepBankPUB-18261827
Source linkPubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In rat retinal cell cultures under hydrogen peroxide attack, exogenous humanin peptide promoted cell survival.

    In plain wordsIn rat retinal cells in a dish, added humanin helped cells survive hydrogen peroxide damage.

    Peptide
    Humanin
    Outcome
    IncreaseRetinal neuron survival under hydrogen peroxide with exogenous humanin
    Study

    ratn: not reported in source

    Mixed rat retinal cell cultures
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    whereas exogenous humanin peptide, an analog of rattin, promoted cell survival in cultures under hydrogen peroxide attacks.
    1 context sentence
    Summary · context
    In this study, we tested the effects of tetramethylpyrazine on the viability of both neuronal and non-neuronal cells in mixed rat retinal cell cultures during a long-term cultivation or following hydrogen peroxide treatments.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02LabEndogenous levelIn vitro (cells)Mechanism

    Hydrogen peroxide treatment was accompanied by loss of rattin peptide in cultured rat retinal cells.

    In plain wordsIn rat retinal cells in a dish, hydrogen peroxide lowered the cells' own rattin, a peptide related to humanin.

    Peptide
    Humanin
    Outcome
    DecreaseRattin peptide level after hydrogen peroxide
    Study

    ratn: not reported in source

    Mixed rat retinal cell cultures
    Outcome group
    Neuroprotection · Eye

    Source sentences

    Summary
    Hydrogen peroxide treatments induced remarkable increases in lipid peroxidation and mitochondrial reactive oxygen species (ROS) generation paralleled by the loss of mitochondrial membrane potential, microtubule-associated protein-2 (MAP-2) in neuronal soma and rattin peptide in cultured cells.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  2. 03LabEndogenous levelIn vitro (cells)Mechanism

    Tetramethylpyrazine retained the abundance of rattin in rat retinal cell cultures under hydrogen peroxide.

    In plain wordsIn rat retinal cells in a dish, tetramethylpyrazine kept the cells' own rattin from falling after hydrogen peroxide damage.

    Peptide
    Humanin
    Outcome
    IncreaseRattin abundance with tetramethylpyrazine under hydrogen peroxide
    Study

    ratn: not reported in source

    Mixed rat retinal cell cultures
    Comparator
    Hydrogen peroxide without tetramethylpyrazine
    Outcome group
    Neuroprotection · Eye

    Source sentences

    Summary
    Addition of tetramethylpyrazine in the cultures efficiently attenuated the signs of oxidative stress and retained abundance of MAP-2 and rattin in association with cell survival.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 04LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    siRNA-mediated downregulation of rattin significantly increased the number of degenerating cells in rat retinal cell cultures.

    In plain wordsIn rat retinal cells in a dish, switching off the rattin gene increased the number of dying cells.

    Peptide
    Humanin
    Outcome
    IncreaseRetinal neuron degeneration after siRNA knockdown of rattin
    Study

    ratn: not reported in source

    Mixed rat retinal cell cultures
    Outcome group
    Neuroprotection · Eye

    Source sentences

    Summary
    siRNA-mediated downregulation of MAP-2 or rattin significantly increased the vulnerability of retinal neurons or the number of degenerating cells in the cultures

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.