Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreas.

Silvestre RA, Egido EM, Hernández R, Marco J

The Journal of endocrinology1 Feb 2008Cited by 51 (Europe PMC)

PMID18252951DOI10.1677/joe-07-0454PepBankPUB-18252951

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-54 (metastin).

01LabNot a test of Kisspeptin-54 (metastin) aloneEx vivo tissueMechanism
In the perfused rat pancreas, the fragment kisspeptin-13 reduced glucose-induced insulin secretion in a dose-dependent manner.
In plain wordsIn a rat pancreas in the lab, a short kisspeptin fragment lowered insulin release in response to glucose.
Peptide
Kisspeptin-54 (metastin)
Outcome
DecreaseGlucose-induced insulin secretion
Study
ratn: not reported in source
Perfused rat pancreas
Outcome group
Glycemic control · Metabolic and weight
Measurements
IC50
1.2 nM
glucose-induced insulin secretion
Source sentences
Summary
Kisspeptin-13 reduced glucose-induced insulin secretion in a dose-dependent manner (IC(50)=1.2 nM
2 context sentences(design, population, supporting numbers)
Summary · context
The study was performed in the perfused rat pancreas.
Summary · context
Glucose, arginine, carbachol, and exendin-4 were used as secretagogues.
In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).
Report a problemFND-1825295101
02LabNot a test of Kisspeptin-54 (metastin) aloneEx vivo tissueMechanism
In the perfused rat pancreas, kisspeptin-13 inhibited the insulin response to carbachol.
In plain wordsIn a rat pancreas in the lab, a short kisspeptin fragment lowered the insulin response to carbachol.
Peptide
Kisspeptin-54 (metastin)
Outcome
DecreaseCarbachol-induced insulin response
Study
ratn: not reported in source
Perfused rat pancreas
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
inhibited the insulin responses to both carbachol and exendin-4.
2 context sentences(design, population, supporting numbers)
Summary · context
The study was performed in the perfused rat pancreas.
Summary · context
Glucose, arginine, carbachol, and exendin-4 were used as secretagogues.
In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).
Report a problemFND-1825295102
03LabNot a test of Kisspeptin-54 (metastin) aloneEx vivo tissueMechanism
In the perfused rat pancreas, kisspeptin-13 inhibited the insulin response to exendin-4.
In plain wordsIn a rat pancreas in the lab, a short kisspeptin fragment lowered the insulin response to exendin-4.
Peptide
Kisspeptin-54 (metastin)
Outcome
DecreaseExendin-4-induced insulin response
Study
ratn: not reported in source
Perfused rat pancreas
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
inhibited the insulin responses to both carbachol and exendin-4.
2 context sentences(design, population, supporting numbers)
Summary · context
The study was performed in the perfused rat pancreas.
Summary · context
Glucose, arginine, carbachol, and exendin-4 were used as secretagogues.
In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).
Report a problemFND-1825295103
04LabNot a test of Kisspeptin-54 (metastin) aloneEx vivo tissueMechanism
In the perfused rat pancreas, kisspeptin-13 blocked arginine-induced insulin secretion.
In plain wordsIn a rat pancreas in the lab, a short kisspeptin fragment blocked insulin release caused by arginine.
Peptide
Kisspeptin-54 (metastin)
Outcome
DecreaseArginine-induced insulin secretion
Study
ratn: not reported in source
Perfused rat pancreas
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
Kisspeptin-13 blocked arginine-induced insulin secretion without affecting the glucagon or somatostatin responses to this amino acid, thus indicating that kisspeptin-13 influences B cells directly, rather than through an A- or D-cell paracrine effect.
2 context sentences(design, population, supporting numbers)
Summary · context
The study was performed in the perfused rat pancreas.
Summary · context
Glucose, arginine, carbachol, and exendin-4 were used as secretagogues.
In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).
Report a problemFND-1825295104
05LabNot a test of Kisspeptin-54 (metastin) aloneEx vivo tissueMechanism
In the perfused rat pancreas, kisspeptin-13 did not affect the glucagon response to arginine.
In plain wordsIn a rat pancreas in the lab, a short kisspeptin fragment did not change glucagon release caused by arginine.
Peptide
Kisspeptin-54 (metastin)
Outcome
No significant changeArginine-induced glucagon response
Study
ratn: not reported in source
Perfused rat pancreas
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
Kisspeptin-13 blocked arginine-induced insulin secretion without affecting the glucagon or somatostatin responses to this amino acid, thus indicating that kisspeptin-13 influences B cells directly, rather than through an A- or D-cell paracrine effect.
2 context sentences(design, population, supporting numbers)
Summary · context
The study was performed in the perfused rat pancreas.
Summary · context
Glucose, arginine, carbachol, and exendin-4 were used as secretagogues.
In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).
Report a problemFND-1825295105
06LabNot a test of Kisspeptin-54 (metastin) aloneEx vivo tissueMechanism
In the perfused rat pancreas, kisspeptin-13 did not affect the somatostatin response to arginine.
In plain wordsIn a rat pancreas in the lab, a short kisspeptin fragment did not change somatostatin release caused by arginine.
Peptide
Kisspeptin-54 (metastin)
Outcome
No significant changeArginine-induced somatostatin response
Study
ratn: not reported in source
Perfused rat pancreas
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
Kisspeptin-13 blocked arginine-induced insulin secretion without affecting the glucagon or somatostatin responses to this amino acid, thus indicating that kisspeptin-13 influences B cells directly, rather than through an A- or D-cell paracrine effect.
2 context sentences(design, population, supporting numbers)
Summary · context
The study was performed in the perfused rat pancreas.
Summary · context
Glucose, arginine, carbachol, and exendin-4 were used as secretagogues.
In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).
Report a problemFND-1825295106
07LabNot a test of Kisspeptin-54 (metastin) aloneEx vivo tissueMechanism
In the perfused pancreas of pertussis toxin-treated rats, kisspeptin-13 still reduced the insulin response to exendin-4.
In plain wordsIn a pancreas from toxin-treated rats in the lab, a short kisspeptin fragment still lowered the insulin response to exendin-4.
Peptide
Kisspeptin-54 (metastin)
Outcome
DecreaseExendin-4 insulin response in pertussis toxin-treated rats
Study
ratn: not reported in source
Perfused rat pancreas
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
The reduction of the insulin response to exendin-4 induced by kisspeptin-13 was also observed in pertussis toxin-treated rats, thus suggesting an inhibition independent of G(i) proteins.
2 context sentences(design, population, supporting numbers)
Summary · context
The study was performed in the perfused rat pancreas.
Summary · context
Glucose, arginine, carbachol, and exendin-4 were used as secretagogues.
In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).
Report a problemFND-1825295107

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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