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Study · In vitro (cells) · rat · 2008

6 results

Proliferative and protective effects of growth hormone secretagogues on adult rat hippocampal progenitor cells.

Johansson I, Destefanis S, Aberg ND, Aberg MA, Blomgren K, Zhu C, Ghè C, Granata R, Ghigo E, Muccioli G, Eriksson PS, Isgaard J

Endocrinology24 Jan 2008Cited by 53 (Europe PMC)

PMID18218693 (opens in a new tab)DOI10.1210/en.2007-0733 (opens in a new tab)PepBankPUB-18218693
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In adult rat hippocampal progenitor cells, hexarelin increased 3H-thymidine incorporation, indicating increased cell proliferation.

    In plain wordsIn rat brain progenitor cells in a dish, hexarelin increased cell growth.

    Peptide
    Hexarelin
    Outcome
    IncreaseCell proliferation (3H-thymidine incorporation)
    Study

    ratn: not reported in source

    Adult rat hippocampal progenitor (AHP) cells
    Outcome group
    Cell proliferation and differentiation · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both hexarelin and ghrelin stimulated increased incorporation of (3)H-thymidine, indicating an increased cell proliferation.
    1 context sentence
    Summary · context
    The aim of the present study was to investigate whether GHS could stimulate cellular proliferation and exert cell protective effects in adult rat hippocampal progenitor (AHP) cells.
  2. 02LabIn vitro (cells)Efficacy outcome

    In adult rat hippocampal progenitor cells, hexarelin, but not ghrelin, protected against growth factor deprivation-induced apoptosis (annexin V binding and caspase-3 activity).

    In plain wordsIn rat brain progenitor cells in a dish, hexarelin reduced cell death by apoptosis, but ghrelin did not.

    Peptide
    Hexarelin
    Outcome
    DecreaseApoptosis after growth factor deprivation
    Study

    ratn: not reported in source

    Adult rat hippocampal progenitor (AHP) cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    hexarelin, but not ghrelin, showed protection against growth factor deprivation-induced apoptosis, as measured by annexin V binding and caspase-3 activity
    2 context sentences
    Summary · context
    Hexarelin, but not ghrelin, also showed a significant inhibition of apoptosis and necrosis.
    Summary · context
    The aim of the present study was to investigate whether GHS could stimulate cellular proliferation and exert cell protective effects in adult rat hippocampal progenitor (AHP) cells.
  3. 03LabIn vitro (cells)Efficacy outcome

    In adult rat hippocampal progenitor cells, hexarelin, but not ghrelin, protected against necrosis measured by lactate dehydrogenase release.

    In plain wordsIn rat brain progenitor cells in a dish, hexarelin reduced cell death by necrosis, but ghrelin did not.

    Peptide
    Hexarelin
    Outcome
    DecreaseNecrosis (lactate dehydrogenase release)
    Study

    ratn: not reported in source

    Adult rat hippocampal progenitor (AHP) cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    hexarelin, but not ghrelin, showed protection against growth factor deprivation-induced apoptosis, as measured by annexin V binding and caspase-3 activity and also against necrosis, as measured by lactate dehydrogenase release
    2 context sentences
    Summary · context
    Hexarelin, but not ghrelin, also showed a significant inhibition of apoptosis and necrosis.
    Summary · context
    The aim of the present study was to investigate whether GHS could stimulate cellular proliferation and exert cell protective effects in adult rat hippocampal progenitor (AHP) cells.
  4. 04LabIn vitro (cells)Mechanism

    In adult rat hippocampal progenitor cells, hexarelin activated the MAPK pathway.

    In plain wordsIn rat brain progenitor cells in a dish, hexarelin switched on the MAPK signaling pathway.

    Peptide
    Hexarelin
    Outcome
    IncreaseMAPK pathway activation
    Study

    ratn: not reported in source

    Adult rat hippocampal progenitor (AHP) cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hexarelin activated the MAPK and the phosphatidylinositol 3-kinase/Akt pathways, whereas ghrelin activated only the MAPK pathway.
    1 context sentence
    Summary · context
    The aim of the present study was to investigate whether GHS could stimulate cellular proliferation and exert cell protective effects in adult rat hippocampal progenitor (AHP) cells.
  5. 05LabIn vitro (cells)Mechanism

    In adult rat hippocampal progenitor cells, hexarelin, but not ghrelin, activated the phosphatidylinositol 3-kinase/Akt pathway.

    In plain wordsIn rat brain progenitor cells in a dish, hexarelin switched on the PI3K/Akt signaling pathway, but ghrelin did not.

    Peptide
    Hexarelin
    Outcome
    IncreasePhosphatidylinositol 3-kinase/Akt pathway activation
    Study

    ratn: not reported in source

    Adult rat hippocampal progenitor (AHP) cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hexarelin activated the MAPK and the phosphatidylinositol 3-kinase/Akt pathways, whereas ghrelin activated only the MAPK pathway.
    1 context sentence
    Summary · context
    The aim of the present study was to investigate whether GHS could stimulate cellular proliferation and exert cell protective effects in adult rat hippocampal progenitor (AHP) cells.
  6. 06LabIn vitro (cells)Activity measurement

    Adult rat hippocampal progenitor cells did not express the GHS receptor 1a, but hexarelin showed specific binding, suggesting an alternative GHS receptor subtype.

    In plain wordsIn rat brain progenitor cells in a dish, hexarelin bound to the cells even though they lacked the GHS-R1a receptor.

    Peptide
    Hexarelin
    Outcome
    Not applicableSpecific binding in cells lacking GHS receptor 1a
    Study

    ratn: not reported in source

    Adult rat hippocampal progenitor (AHP) cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AHP cells did not express the GHS receptor 1a, but binding studies could show specific binding of both hexarelin and ghrelin, suggesting effects to be mediated by an alternative GHS receptor subtype.
    1 context sentence
    Summary · context
    The aim of the present study was to investigate whether GHS could stimulate cellular proliferation and exert cell protective effects in adult rat hippocampal progenitor (AHP) cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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