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Study · Not a test of the peptide alone · 2008

2 results

New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations.

Moulin A, Demange L, Ryan J, Mousseaux D, Sanchez P, Bergé G, Gagne D, Perrissoud D, Locatelli V, Torsello A, Galleyrand JC, Fehrentz JA, Martinez J

Journal of medicinal chemistry15 Jan 2008Cited by 53 (Europe PMC)

PMID18193826 (opens in a new tab)DOI10.1021/jm701292s (opens in a new tab)PepBankPUB-18193826
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

  1. 01AnimalNot a test of Hexarelin aloneAnimal study (in vivo)Activity measurement

    In rodents, triazole compounds 5 and 34 acted as potent in vivo antagonists of hexarelin-stimulated food intake.

    In plain wordsIn rodents, two new compounds blocked the increase in food intake caused by hexarelin.

    Peptide
    Hexarelin
    Outcome
    DecreaseHexarelin-stimulated food intake with compounds 5 and 34
    Study

    rodentsn: not reported in source

    In vivo, rodents
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    Compounds 5 and 34 acted as potent in vivo antagonists of hexarelin-stimulated food intake.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  2. 02AnimalNot a test of Hexarelin aloneAnimal study (in vivo)Activity measurement

    In rodents, triazole compounds 5 and 34 did not antagonize growth hormone secretion induced by hexarelin.

    In plain wordsIn rodents, two new compounds did not block the growth hormone release caused by hexarelin.

    Peptide
    Hexarelin
    Outcome
    No significant changeHexarelin-induced GH secretion with compounds 5 and 34
    Study

    rodentsn: not reported in source

    In vivo, rodents
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    These two compounds did not stimulate growth hormone secretion in rodents and did not antagonize growth hormone secretion induced by hexarelin.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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