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Study · Animal study (in vivo) · rat · 2008

6 results

Role of carnosine in preventing thioacetamide-induced liver injury in the rat.

Mehmetçik G, Ozdemirler G, Koçak-Toker N, Cevikbaş U, Uysal M

Peptides22 Nov 2007Cited by 40 (Europe PMC)

PMID18164100 (opens in a new tab)DOI10.1016/j.peptides.2007.11.008 (opens in a new tab)PepBankPUB-18164100
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In TAA-treated rats, plasma transaminase activities approached normal values with carnosine.

    In plain wordsIn rats, carnosine moved plasma transaminase activities toward normal compared with TAA treatment without carnosine.

    Peptide
    L-carnosine
    Outcome
    DecreasePlasma transaminase activities
    Study

    ratn: not reported in source

    thioacetamide-induced liver injury
    Comparator
    TAA-treated rats without carnosine
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    When carnosine was co-administered with TAA in rats, plasma transaminase activities were found to approach to normal values in rats.
    2 context sentences
    Summary · context
    TAA administration resulted in hepatic necrosis, significant increases in plasma transaminase activities as well as hepatic lipid peroxide levels.
    Summary · context
    Rats were injected intraperitoneally with TAA (500 mg/kg) and carnosine (250 mg/kg, intraperitoneal) was co-administered with TAA. All animals were killed 24 h after injections.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, histological findings suggested that carnosine prevented TAA-induced hepatic necrosis.

    In plain wordsIn rats, tissue findings suggested that carnosine reduced liver necrosis compared with TAA treatment without carnosine.

    Peptide
    L-carnosine
    Outcome
    DecreaseHepatic necrosis
    Study

    ratn: not reported in source

    thioacetamide-induced liver injury
    Comparator
    TAA-treated rats without carnosine
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Histological findings also suggested that carnosine has preventive effect on TAA-induced hepatic necrosis.
    1 context sentence
    Summary · context
    Rats were injected intraperitoneally with TAA (500 mg/kg) and carnosine (250 mg/kg, intraperitoneal) was co-administered with TAA. All animals were killed 24 h after injections.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In TAA-treated rats, carnosine significantly decreased liver lipid peroxide levels.

    In plain wordsIn rats, carnosine reduced liver lipid peroxides compared with TAA treatment without carnosine.

    Peptide
    L-carnosine
    Outcome
    DecreaseLiver lipid peroxides
    Study

    ratn: not reported in source

    thioacetamide-induced liver injury
    Comparator
    TAA-treated rats without carnosine
    Outcome group
    Oxidative stress · Liver
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Carnosine treatment caused significant decreases in lipid peroxide levels in TAA-treated rats without any changes in enzymatic and non-enzymatic antioxidants except vitamin E in the liver of rats.
    1 context sentence
    Summary · context
    Rats were injected intraperitoneally with TAA (500 mg/kg) and carnosine (250 mg/kg, intraperitoneal) was co-administered with TAA. All animals were killed 24 h after injections.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In TAA-treated rats, carnosine did not change liver enzymatic antioxidants.

    In plain wordsIn rats, carnosine did not change liver enzymatic antioxidants compared with TAA treatment without carnosine.

    Peptide
    L-carnosine
    Outcome
    No significant changeEnzymatic antioxidants
    Study

    ratn: not reported in source

    thioacetamide-induced liver injury
    Comparator
    TAA-treated rats without carnosine
    Outcome group
    Oxidative stress · Liver
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Carnosine treatment caused significant decreases in lipid peroxide levels in TAA-treated rats without any changes in enzymatic and non-enzymatic antioxidants except vitamin E in the liver of rats.
    1 context sentence
    Summary · context
    Rats were injected intraperitoneally with TAA (500 mg/kg) and carnosine (250 mg/kg, intraperitoneal) was co-administered with TAA. All animals were killed 24 h after injections.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In TAA-treated rats, carnosine did not change liver non-enzymatic antioxidants except vitamin E.

    In plain wordsIn rats, carnosine did not change liver non-enzymatic antioxidants except vitamin E compared with TAA treatment without carnosine.

    Peptide
    L-carnosine
    Outcome
    No significant changeNon-enzymatic antioxidants except vitamin E
    Study

    ratn: not reported in source

    thioacetamide-induced liver injury
    Comparator
    TAA-treated rats without carnosine
    Outcome group
    Oxidative stress · Liver
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Carnosine treatment caused significant decreases in lipid peroxide levels in TAA-treated rats without any changes in enzymatic and non-enzymatic antioxidants except vitamin E in the liver of rats.
    1 context sentence
    Summary · context
    Rats were injected intraperitoneally with TAA (500 mg/kg) and carnosine (250 mg/kg, intraperitoneal) was co-administered with TAA. All animals were killed 24 h after injections.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In TAA-treated rats, vitamin E was the exception to unchanged liver antioxidants with carnosine; its direction was not stated.

    In plain wordsIn rats, vitamin E was the exception to unchanged liver antioxidants with carnosine compared with TAA treatment without carnosine.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedVitamin E
    Study

    ratn: not reported in source

    thioacetamide-induced liver injury
    Comparator
    TAA-treated rats without carnosine
    Outcome group
    Oxidative stress · Liver
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Carnosine treatment caused significant decreases in lipid peroxide levels in TAA-treated rats without any changes in enzymatic and non-enzymatic antioxidants except vitamin E in the liver of rats.
    1 context sentence
    Summary · context
    Rats were injected intraperitoneally with TAA (500 mg/kg) and carnosine (250 mg/kg, intraperitoneal) was co-administered with TAA. All animals were killed 24 h after injections.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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