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Study · In vitro (cells) · bovine · 2008

5 results

Kisspeptin-10 stimulates the secretion of growth hormone and prolactin directly from cultured bovine anterior pituitary cells.

Kadokawa H, Suzuki S, Hashizume T

Animal reproduction science19 Nov 2007Cited by 61 (Europe PMC)

PMID18096333 (opens in a new tab)DOI10.1016/j.anireprosci.2007.11.005 (opens in a new tab)PepBankPUB-18096333
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In pituitary cells of 1-month-old calves, kisspeptin‑10 at 100 nM and above, but not at 10 nM, increased GH secretion.

    In plain wordsIn pituitary cells from young calves, kisspeptin‑10 raised growth hormone release at 100 nM and above, not at 10 nM.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGH secretion, 1-month-old calves
    Study

    bovinen: not reported in source

    anterior pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100, 1000 and 10,000 nM · in vitro incubation · 2 hAs given in this study (bovine).

    Source sentences

    Summary
    Kisspeptin-10 at 100 nM (P<0.05), 1000 nM (P<0.01) and 10,000 nM (P<0.01), but not at 10 nM, significantly stimulated GH secretion from the AP cells of 1-month-old calves
    1 context sentence
    Summary · context
    The AP cells, which were prepared from 1- or 8-month-old male calves, were incubated for 2h with the peptides.
  2. 02LabIn vitro (cells)Activity measurement

    In pituitary cells of 8-month-old calves, kisspeptin‑10 at 1000 nM and 10,000 nM, but not at 10 nM or 100 nM, increased GH secretion.

    In plain wordsIn pituitary cells from older calves, kisspeptin‑10 raised growth hormone release only at 1000 and 10,000 nM.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGH secretion, 8-month-old calves
    Study

    bovinen: not reported in source

    anterior pituitary cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1000 and 10,000 nM · in vitro incubation · 2 hAs given in this study (bovine).

    Source sentences

    Summary
    while in 8-month-old calves it was significantly (P<0.05) stimulated at 1000 nM (P<0.01) and 10,000 nM (P<0.01), but not at 10nM and 100 nM.
    1 context sentence
    Summary · context
    The AP cells, which were prepared from 1- or 8-month-old male calves, were incubated for 2h with the peptides.
  3. 03LabIn vitro (cells)Activity measurement

    The GH response to kisspeptin‑10 at 100, 1000 and 10,000 nM was greater in pituitary cells of 1-month-old calves than of 8-month-old calves.

    In plain wordsKisspeptin‑10 raised growth hormone release more in pituitary cells from young calves than from older calves.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGH response, 1-month-old versus 8-month-old calves
    Study

    bovinen: not reported in source

    anterior pituitary cells
    Comparator
    8-month-old calves
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100, 1000 and 10,000 nM · in vitro incubation · 2 hAs given in this study (bovine).

    Source sentences

    Summary
    The response of GH to 100 nM (P<0.01), 1000 nM (P<0.05) and 10,000 nM (P<0.01) kisspeptin-10 in the AP cells of 1-month-old calves was significantly greater than in those of 8-month-old calves.
    1 context sentence
    Summary · context
    The AP cells, which were prepared from 1- or 8-month-old male calves, were incubated for 2h with the peptides.
  4. 04LabIn vitro (cells)Activity measurement

    In pituitary cells of 1-month-old calves, no tested dose of kisspeptin‑10 changed prolactin secretion.

    In plain wordsIn pituitary cells from young calves, kisspeptin‑10 did not change prolactin release at any tested dose.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changePRL secretion, 1-month-old calves
    Study

    bovinen: not reported in source

    anterior pituitary cells
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated · in vitro incubation · 2 hAs given in this study (bovine).

    Source sentences

    Summary
    All tested doses of kisspeptin-10 had no effect on PRL secretion from AP cells of 1-month-old calves.
    1 context sentence
    Summary · context
    The AP cells, which were prepared from 1- or 8-month-old male calves, were incubated for 2h with the peptides.
  5. 05LabIn vitro (cells)Activity measurement

    In pituitary cells of 8-month-old calves, kisspeptin‑10 at 1000 nM and 10,000 nM, but not at lower concentrations, increased prolactin secretion.

    In plain wordsIn pituitary cells from older calves, kisspeptin‑10 raised prolactin release only at 1000 and 10,000 nM.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePRL secretion, 8-month-old calves
    Study

    bovinen: not reported in source

    anterior pituitary cells
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    1000 and 10,000 nM · in vitro incubation · 2 hAs given in this study (bovine).

    Source sentences

    Summary
    However, 1000 nM (P<0.05) and 10,000 nM (P<0.01), but not lower concentrations, of kisspeptin-10 significantly stimulated PRL secretion from the AP cells of 8-month-old calves.
    1 context sentence
    Summary · context
    The AP cells, which were prepared from 1- or 8-month-old male calves, were incubated for 2h with the peptides.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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