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Study · Animal study (in vivo) · rat · 2008

3 results

Effects of kisspeptin-10 on the electrophysiological manifestation of gonadotropin-releasing hormone pulse generator activity in the female rat.

Kinsey-Jones JS, Li XF, Luckman SM, O'Byrne KT

Endocrinology6 Dec 2007Cited by 64 (Europe PMC)

PMID18063679 (opens in a new tab)DOI10.1210/en.2007-1505 (opens in a new tab)PepBankPUB-18063679
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized female rats, intravenous kisspeptin‑10 raised LH secretion in a dose-dependent way.

    In plain wordsIn female rats, intravenous kisspeptin‑10 raised LH release, and higher doses gave a larger rise.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH secretion
    Study

    ratn: not reported in source

    in vivo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    7.5, 35 and 100 nmol · intravenous infusionAs given in this study (rat).

    Source sentences

    Summary
    Intravenous infusion of kisspeptin-10 (7.5, 35, and 100 nmol) induced a dose-dependent increase in LH secretion.
    1 context sentence
    Summary · context
    Adult Sprague Dawley rats were ovariectomized and chronically implanted with electrodes in the arcuate nucleus
  2. 02AnimalAnimal study (in vivo)Mechanism

    In ovariectomized female rats, the GnRH antagonist cetrorelix blocked the LH increase caused by kisspeptin‑10 at 100 nmol.

    In plain wordsIn female rats, a GnRH blocker stopped the LH rise that kisspeptin‑10 normally causes.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseKisspeptin-induced LH increase with GnRH antagonist cetrorelix
    Study

    ratn: not reported in source

    in vivo
    Comparator
    kisspeptin-10 without cetrorelix
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 nmol · intravenous infusionAs given in this study (rat).

    Source sentences

    Summary
    The stimulatory effect of kisspeptin-10 (100 nmol) on LH secretion was blocked by the GnRH antagonist cetrorelix, precluding a singular action on gonadotropes.
    1 context sentence
    Summary · context
    Adult Sprague Dawley rats were ovariectomized and chronically implanted with electrodes in the arcuate nucleus
  3. 03AnimalAnimal study (in vivo)Mechanism

    In ovariectomized female rats, kisspeptin‑10 at 100 nmol raised LH release without changing the frequency of GnRH pulse generator electrical activity volleys.

    In plain wordsIn female rats, kisspeptin‑10 raised LH release but did not change how often the brain's GnRH pulse generator fired.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeGnRH pulse generator multiunit electrical activity volley frequency
    Study

    ratn: not reported in source

    in vivo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 nmol · intravenous infusionAs given in this study (rat).

    Source sentences

    Summary
    Unexpectedly, however, the marked increase in LH release in response to kisspeptin-10 (100 nmol) administration was not accompanied by any change in multiunit electrical activity volley frequency.
    1 context sentence
    Summary · context
    Adult Sprague Dawley rats were ovariectomized and chronically implanted with electrodes in the arcuate nucleus

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 4Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 3

    27 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    9 Oct 2026, 18:17 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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