Can pregnancy rate be improved in gonadotropin-releasing hormone (GnRH) antagonist cycles by administering GnRH agonist before oocyte retrieval? A prospective, randomized study.

Schachter M, Friedler S, Ron-El R, Zimmerman AL, Strassburger D, Bern O, Raziel A

Fertility and sterility26 Nov 2007Cited by 73 (Europe PMC)

PMID18023439DOI10.1016/j.fertnstert.2007.07.1316PepBankPUB-18023439

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

01HumanRandomized controlled trialEfficacy outcome
In started IVF cycles, the pregnancy rate increase with added triptorelin versus hCG alone was not statistically significant.
In plain wordsIn started IVF cycles, pregnancy rates did not differ significantly between added triptorelin and hCG alone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changePregnancy per started cycle
Study
n = 221
Comparator
hCG alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mg · subcutaneousAs given in this study (human).
Measurements
Pregnancy rate per started cycle
40.9%
added triptorelin (study group)
Pregnancy rate per started cycle
28.3%
hCG alone (control group)
Source sentences
Summary
However, the improvement in pregnancy rate per started cycle did not reach statistical significance (40.9% vs. 28.3%).
2 context sentences(design, population, supporting numbers)
Summary · context
Two hundred twenty-one patients intended for GnRH antagonist protocol IVF.
Summary · context
The control group received hCG (5,000 U) 34 hours before oocyte aspiration, and the study group received triptorelin (0.2 mg SC) in addition to hCG.
Report a problemFND-1802343907
02HumanRandomized controlled trialEfficacy outcome
In completed IVF cycles, pregnancy rates were significantly higher with added triptorelin than hCG alone.
In plain wordsIn completed IVF cycles, pregnancy rates were higher with added triptorelin than hCG alone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreasePregnancy rate per completed cycle
Study
n = 200
Comparator
hCG alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mg · subcutaneousAs given in this study (human).
Measurements
Pregnancy rate
44.3%
added triptorelin
Pregnancy rate
29.1%
hCG alone
Source sentences
Summary
The pregnancy rate in completed cycles and the ongoing pregnancy rate per ET were significantly higher in the study group than in the control group: 29.1% (30 of 103) in the control group and 44.3% (43 of 97) in the study group, and 22.3% (23 of 103) and 36.1% (35 of 97), respectively.
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 200 ET cycles were carried out: 97 in the study group and 103 in the control group.
Summary · context
Two hundred twenty-one patients intended for GnRH antagonist protocol IVF.
Summary · context
The control group received hCG (5,000 U) 34 hours before oocyte aspiration, and the study group received triptorelin (0.2 mg SC) in addition to hCG.
Report a problemFND-1802343905
03HumanRandomized controlled trialEfficacy outcome
In IVF cycles with embryo transfer, ongoing pregnancy was significantly higher with added triptorelin than hCG alone.
In plain wordsAfter IVF embryo transfer, ongoing pregnancy was higher with added triptorelin than hCG alone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOngoing pregnancy per embryo transfer
Study
n = 200
Comparator
hCG alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mg · subcutaneousAs given in this study (human).
Measurements
Ongoing pregnancy
36.1%
added triptorelin
Ongoing pregnancy
22.3%
hCG alone
Source sentences
Summary
The pregnancy rate in completed cycles and the ongoing pregnancy rate per ET were significantly higher in the study group than in the control group: 29.1% (30 of 103) in the control group and 44.3% (43 of 97) in the study group, and 22.3% (23 of 103) and 36.1% (35 of 97), respectively.
3 context sentences(design, population, supporting numbers)
Summary · context
A total of 200 ET cycles were carried out: 97 in the study group and 103 in the control group.
Summary · context
Two hundred twenty-one patients intended for GnRH antagonist protocol IVF.
Summary · context
The control group received hCG (5,000 U) 34 hours before oocyte aspiration, and the study group received triptorelin (0.2 mg SC) in addition to hCG.
Report a problemFND-1802343906
04HumanRandomized controlled trialEfficacy outcome
In GnRH antagonist IVF cycles, added triptorelin increased retrieval-day FSH compared with hCG alone.
In plain wordsIn IVF cycles, added triptorelin increased FSH on egg retrieval day compared with hCG alone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseFSH on oocyte retrieval day
Study
n: not reported in source
Comparator
hCG alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mg · subcutaneousAs given in this study (human).
Measurements
Oocyte pick-up day FSH
11.26 IU/L
added triptorelin (study group)
Oocyte pick-up day FSH
6.27 IU/L
hCG alone (control group)
FSH, study group 95% CI lower limit
9.88 IU/L
added triptorelin (study group)
FSH, study group 95% CI upper limit
12.52 IU/L
added triptorelin (study group)
FSH, control group 95% CI lower limit
5.76 IU/L
hCG alone (control group)
FSH, control group 95% CI upper limit
8.77 IU/L
hCG alone (control group)
Source sentences
Summary
None of the cycle parameters of the study or control groups differed, excepting mean oocyte pick-up day FSH (11.26 IU/L [95% confidence interval (CI) 9.88-12.52] vs. 6.27 IU/L [95% CI 5.76-8.77]) and LH levels (5.19 IU/L [95% CI 4.47-5.9] vs. 3.28 IU/L [95% CI 2.22-4.18]).
2 context sentences(design, population, supporting numbers)
Summary · context
Two hundred twenty-one patients intended for GnRH antagonist protocol IVF.
Summary · context
The control group received hCG (5,000 U) 34 hours before oocyte aspiration, and the study group received triptorelin (0.2 mg SC) in addition to hCG.
Report a problemFND-1802343901
05HumanRandomized controlled trialEfficacy outcome
In GnRH antagonist IVF cycles, added triptorelin increased retrieval-day LH compared with hCG alone.
In plain wordsIn IVF cycles, added triptorelin increased LH on egg retrieval day compared with hCG alone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseLH on oocyte retrieval day
Study
n: not reported in source
Comparator
hCG alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mg · subcutaneousAs given in this study (human).
Measurements
Oocyte pick-up day LH
5.19 IU/L
added triptorelin (study group)
Oocyte pick-up day LH
3.28 IU/L
hCG alone (control group)
LH, study group 95% CI lower limit
4.47 IU/L
added triptorelin (study group)
LH, study group 95% CI upper limit
5.9 IU/L
added triptorelin (study group)
LH, control group 95% CI lower limit
2.22 IU/L
hCG alone (control group)
LH, control group 95% CI upper limit
4.18 IU/L
hCG alone (control group)
Source sentences
Summary
None of the cycle parameters of the study or control groups differed, excepting mean oocyte pick-up day FSH (11.26 IU/L [95% confidence interval (CI) 9.88-12.52] vs. 6.27 IU/L [95% CI 5.76-8.77]) and LH levels (5.19 IU/L [95% CI 4.47-5.9] vs. 3.28 IU/L [95% CI 2.22-4.18]).
2 context sentences(design, population, supporting numbers)
Summary · context
Two hundred twenty-one patients intended for GnRH antagonist protocol IVF.
Summary · context
The control group received hCG (5,000 U) 34 hours before oocyte aspiration, and the study group received triptorelin (0.2 mg SC) in addition to hCG.
Report a problemFND-1802343902
06HumanRandomized controlled trialEfficacy outcome
In GnRH antagonist IVF cycles, other cycle parameters did not differ between added triptorelin and hCG alone.
In plain wordsIn IVF cycles, other cycle measures did not differ between added triptorelin and hCG alone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeOther cycle parameters
Study
n: not reported in source
Comparator
hCG alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mg · subcutaneousAs given in this study (human).
Source sentences
Summary
None of the cycle parameters of the study or control groups differed, excepting mean oocyte pick-up day FSH (11.26 IU/L [95% confidence interval (CI) 9.88-12.52] vs. 6.27 IU/L [95% CI 5.76-8.77]) and LH levels (5.19 IU/L [95% CI 4.47-5.9] vs. 3.28 IU/L [95% CI 2.22-4.18]).
2 context sentences(design, population, supporting numbers)
Summary · context
Two hundred twenty-one patients intended for GnRH antagonist protocol IVF.
Summary · context
The control group received hCG (5,000 U) 34 hours before oocyte aspiration, and the study group received triptorelin (0.2 mg SC) in addition to hCG.
Report a problemFND-1802343903
07HumanRandomized controlled trialEfficacy outcome
In GnRH antagonist IVF cycles, implantation was 19.9% with added triptorelin versus 13.9% with hCG alone.
In plain wordsIn IVF cycles, implantation was higher with added triptorelin than hCG alone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseImplantation rate
Study
n: not reported in source
Comparator
hCG alone
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.2 mg · subcutaneousAs given in this study (human).
Measurements
Implantation rate
19.9%
added triptorelin
Implantation rate
13.9%
hCG alone
Source sentences
Summary
The implantation rate was 19.9% (52 of 261) for the study group and 13.9% (35 of 251) for the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
Two hundred twenty-one patients intended for GnRH antagonist protocol IVF.
Summary · context
The control group received hCG (5,000 U) 34 hours before oocyte aspiration, and the study group received triptorelin (0.2 mg SC) in addition to hCG.
Report a problemFND-1802343904

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials2

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

2 trials · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase not statedNCT07076719

Cell-free DNA Analysis of Spent Embryo Culture Media as a Non-invasive Approach for Preimplantation Genetic Diagnosis

Sohag Universityn = 201 Oct 2023 to 28 Aug 2024

to Evaluate the Feasibility and Accuracy of Using cfDNA Analysis of Spent Embryo Culture Media as a Non-invasive Approach for PGD

Trial page ClinicalTrials.govUpdated 22 Jul 2025

Status unknownNot applicableNCT04717752

A Randomized Controlled Study of Different Trigger Modes of Antagonist Regimen in Patients With Low Ovarian Reserve

Nanjing Universityn = 310est. 20 Jan 2021 to est. 31 Dec 2021

Poor Ovarian Response

Trial page ClinicalTrials.govUpdated 28 Jan 2021

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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