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Study · Not a test of the peptide alone · 2008

4 results

Activity-dependent neurotrophic factor, ADNF, determines the structure characteristics of Colivelin, a fusion protein of ADNF9 and Humanin analog.

Arakawa T, Niikura T, Arisaka F, Kita Y

Journal of peptide science : an official publication of the European Peptide Society1 May 2008Cited by 5 (Europe PMC)

PMID17994638 (opens in a new tab)DOI10.1002/psc.959 (opens in a new tab)PepBankPUB-17994638
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01LabNot a test of Humanin aloneIn vitro (cells)Activity measurement

    Colivelin, a fusion of ADNF9 and a Humanin analog, had neuroprotective activity in the fM range, about 10(3)-10(7) fold higher than Humanin and Humanin analogs.

    In plain wordsIn lab tests, a Humanin-based fusion peptide protected nerve cells at far lower concentrations than Humanin and Humanin analogs.

    Peptide
    Humanin
    Outcome
    IncreaseNeuroprotective activity of Colivelin versus Humanin
    Study

    n: not reported in source

    Comparator
    Humanin and Humanin analogs
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    This fusion resulted in a novel molecule, termed Colivelin, with the neuroprotective activity at fM range, which is approximately 10(3)-10(7) fold higher than the activity of Humanin and Humanin analogs and follows the activity profile of fM-active ADNF9.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02LabNot a test of Humanin aloneIn vitro (cell-free)Other

    The secondary structure of Colivelin was similar to that of ADNF9 but not to that of Humanin.

    In plain wordsIn lab tests, the shape of the fusion peptide Colivelin matched ADNF9 and not Humanin.

    Peptide
    Humanin
    Outcome
    Not applicableSecondary structure of Colivelin
    Study

    n: not reported in source

    Outcome group
    Peptide structure and chemistry · Pharmacology

    Source sentences

    Summary
    The secondary structure of Colivelin was similar to that of ADNF9, but not that of Humanin, and hence was not the average of the contributions of the two peptides fused.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03LabNot a test of Humanin aloneIn vitro (cell-free)Other

    Colivelin was stable and monomeric in PBS.

    In plain wordsIn lab tests, the fusion peptide Colivelin stayed stable and did not clump in a salt buffer.

    Peptide
    Humanin
    Outcome
    Not applicableSelf-association of Colivelin in PBS
    Study

    n: not reported in source

    Outcome group
    Peptide structure and chemistry · Pharmacology

    Source sentences

    Summary
    Colivelin was stable and monomeric in PBS

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 04LabNot a test of Humanin aloneIn vitro (cell-free)Other

    Humanin showed a strong tendency to self-associate in PBS, in contrast to Colivelin.

    In plain wordsIn lab tests, Humanin clumped together strongly in a salt buffer, unlike Colivelin.

    Peptide
    Humanin
    Outcome
    Not applicableSelf-association of Humanin in PBS
    Study

    n: not reported in source

    Outcome group
    Peptide structure and chemistry · Pharmacology

    Source sentences

    Summary
    Colivelin was stable and monomeric in PBS, consistent with the monomeric property of ADNF9, while Humanin showed strong tendency to self-associate.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:32 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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