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Study · Animal study (in vivo) · cba mice · 2007

7 results

[Thymic factors influence on melatonin-producing pineal function in mice of different age: the possible mechanisms].

Labunets IF

Advances in gerontology = Uspekhi gerontologii1 Jan 2007

PMID17969591 (opens in a new tab)PepBankPUB-17969591
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In adult mice, a single thymalin injection significantly increased serum melatonin after 3 h.

    In plain wordsIn mice, a single thymalin injection increased blood melatonin after 3 h in adult animals.

    Peptide
    Thymalin
    Outcome
    IncreaseSerum melatonin at 3 h
    Study

    CBA micen: not reported in source

    Adult mice
    Outcome group
    Sleep · Endocrine and hormones
    Studied dose
    Dose not stated · injectionAs given in this study (CBA mice).

    Source sentences

    Summary
    Significant increase of melatonin serum level in 3 h and decrease in 24 h after one injection of thymic preparation "thymalin" in adult mice was shown.
    1 context sentence
    Summary · context
    The aging peculiarities of thymic factors influence on pineal gland function in CBA mice were investigated.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In adult mice, a single thymalin injection significantly decreased serum melatonin after 24 h.

    In plain wordsIn mice, a single thymalin injection decreased blood melatonin after 24 h in adult animals.

    Peptide
    Thymalin
    Outcome
    DecreaseSerum melatonin at 24 h
    Study

    CBA micen: not reported in source

    Adult mice
    Outcome group
    Sleep · Endocrine and hormones
    Studied dose
    Dose not stated · injectionAs given in this study (CBA mice).

    Source sentences

    Summary
    Significant increase of melatonin serum level in 3 h and decrease in 24 h after one injection of thymic preparation "thymalin" in adult mice was shown.
    1 context sentence
    Summary · context
    The aging peculiarities of thymic factors influence on pineal gland function in CBA mice were investigated.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In adult mice, thymalin activation depended on season and was linked to increased FTS levels.

    In plain wordsIn mice, thymalin activation depended on season and was linked to increased FTS levels in adult animals.

    Peptide
    Thymalin
    Outcome
    IncreaseFTS level in adult mice
    Study

    CBA micen: not reported in source

    Adult mice
    Outcome group
    Immune response · Endocrine and hormones
    Studied dose
    Dose not stated · injectionAs given in this study (CBA mice).

    Source sentences

    Summary
    The activating influence of thymalin was depended on season and linked with increase of thymic serum factor (FTS, thymulin) level and decrease of corticosterone blood level.
    1 context sentence
    Summary · context
    The aging peculiarities of thymic factors influence on pineal gland function in CBA mice were investigated.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In adult mice, thymalin activation depended on season and was linked to decreased blood corticosterone.

    In plain wordsIn mice, thymalin activation depended on season and was linked to lower blood corticosterone in adult animals.

    Peptide
    Thymalin
    Outcome
    DecreaseCorticosterone in adult mice
    Study

    CBA micen: not reported in source

    Adult mice
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · injectionAs given in this study (CBA mice).

    Source sentences

    Summary
    The activating influence of thymalin was depended on season and linked with increase of thymic serum factor (FTS, thymulin) level and decrease of corticosterone blood level.
    1 context sentence
    Summary · context
    The aging peculiarities of thymic factors influence on pineal gland function in CBA mice were investigated.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In old mice, thymic factors including thymalin showed no activating effect on pineal function in vivo.

    In plain wordsIn old mice, thymic factors including thymalin did not activate pineal function in the living animals.

    Peptide
    Thymalin
    Outcome
    No significant changePineal activation in old mice
    Study

    CBA micen: not reported in source

    Old mice
    Outcome group
    Sleep · Endocrine and hormones
    Studied dose
    Dose not stated · injectionAs given in this study (CBA mice).

    Source sentences

    Summary
    The activating influence of thymic factors in vivo and in vitro on pineal function in old mice was not revealed.
    2 context sentences
    Summary · context
    Significant increase of melatonin serum level in 3 h and decrease in 24 h after one injection of thymic preparation "thymalin" in adult mice was shown.
    Summary · context
    The aging peculiarities of thymic factors influence on pineal gland function in CBA mice were investigated.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In old mice, thymalin injection increased FTS content.

    In plain wordsIn mice, thymalin injection increased FTS content in old animals.

    Peptide
    Thymalin
    Outcome
    IncreaseFTS content in old mice
    Study

    CBA micen: not reported in source

    Old mice
    Outcome group
    Immune response · Endocrine and hormones
    Studied dose
    Dose not stated · injectionAs given in this study (CBA mice).

    Source sentences

    Summary
    FTS content increased and cortocosterone level did not change in old mice after injection of thymalin.
    1 context sentence
    Summary · context
    The aging peculiarities of thymic factors influence on pineal gland function in CBA mice were investigated.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In old mice, thymalin injection did not change corticosterone levels.

    In plain wordsIn mice, thymalin injection did not change corticosterone levels in old animals.

    Peptide
    Thymalin
    Outcome
    No significant changeCorticosterone in old mice
    Study

    CBA micen: not reported in source

    Old mice
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · injectionAs given in this study (CBA mice).

    Source sentences

    Summary
    FTS content increased and cortocosterone level did not change in old mice after injection of thymalin.
    1 context sentence
    Summary · context
    The aging peculiarities of thymic factors influence on pineal gland function in CBA mice were investigated.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 12:50 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    14 Oct 2026, 05:02 UTC

    Study results updated

  3. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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