Diminished plasma oxytocin in schizophrenic patients with neuroendocrine dysfunction and emotional deficits.

Goldman M, Marlow-O'Connor M, Torres I, Carter CS

Schizophrenia research24 Oct 2007Cited by 159 (Europe PMC)

PMID17961988PMCIDPMC2277481DOI10.1016/j.schres.2007.09.019PepBankPUB-17961988

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In schizophrenic patients with polydipsia and hyponatremia, plasma oxytocin was lower than in the other three groups.
In plain wordsIn people with schizophrenia and polydipsia with low sodium, the body's own oxytocin in blood was lower than in the other groups.
Peptide
Oxytocin
Outcome
DecreasePlasma oxytocin in polydipsic hyponatremic schizophrenic patients
Study
n = 22
Comparator
Other three groups
Outcome group
Endogenous peptide levels · Mental health and mood
Source sentences
Summary
Results demonstrated that 1) plasma oxytocin levels were lower (p=.006) in hyponatremic patients relative to the other three groups, whose levels were similar and did not change.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we measured plasma oxytocin levels at intervals before and after stress induction in six polydipsic hyponatremic (PHS), four polydipsic normonatremic (PNS), five nonpolydipsic normonatremic schizophrenic (NNS) patients and seven healthy controls.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1796198801
02HumanEndogenous levelObservational studyOther
In the other three groups, plasma oxytocin levels were similar and did not change.
In plain wordsIn the other three groups, the body's own oxytocin levels in blood were similar and did not change.
Peptide
Oxytocin
Outcome
No significant changePlasma oxytocin change after stress in the other three groups
Study
n = 16
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
whose levels were similar and did not change.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we measured plasma oxytocin levels at intervals before and after stress induction in six polydipsic hyponatremic (PHS), four polydipsic normonatremic (PNS), five nonpolydipsic normonatremic schizophrenic (NNS) patients and seven healthy controls.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1796198802
03HumanEndogenous levelObservational studyOther
Plasma oxytocin levels across all subjects were inversely correlated with anterior hippocampal volume.
In plain wordsLower natural oxytocin levels in blood were linked to larger anterior hippocampal volume.
Peptide
Oxytocin
Outcome
Not applicableOxytocin and anterior hippocampal volume
Study
n: not reported in source
Outcome group
Brain and neuronal activity · Mental health and mood
Source sentences
Summary
Oxytocin levels across all subjects were 2) inversely correlated with anterior hippocampal (p=.004)
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we measured plasma oxytocin levels at intervals before and after stress induction in six polydipsic hyponatremic (PHS), four polydipsic normonatremic (PNS), five nonpolydipsic normonatremic schizophrenic (NNS) patients and seven healthy controls.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1796198803
04HumanEndogenous levelObservational studyOther
Plasma oxytocin levels were not correlated with posterior hippocampal or amygdala volumes.
In plain wordsThe body's own oxytocin levels in blood were not linked to posterior hippocampal or amygdala volumes.
Peptide
Oxytocin
Outcome
No significant changeOxytocin and posterior hippocampal or amygdala volume
Study
n: not reported in source
Outcome group
Brain and neuronal activity · Mental health and mood
Source sentences
Summary
(but not posterior hippocampal or amygdala volumes)
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we measured plasma oxytocin levels at intervals before and after stress induction in six polydipsic hyponatremic (PHS), four polydipsic normonatremic (PNS), five nonpolydipsic normonatremic schizophrenic (NNS) patients and seven healthy controls.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1796198804
05HumanEndogenous levelObservational studyOther
Plasma oxytocin levels were directly correlated with the integrity of hippocampal-mediated HPA feedback.
In plain wordsHigher natural oxytocin levels in blood were linked to better HPA feedback.
Peptide
Oxytocin
Outcome
Not applicableOxytocin and hippocampal-mediated HPA feedback integrity
Study
n: not reported in source
Outcome group
Stress hormones · Mental health and mood
Source sentences
Summary
directly correlated with the integrity of hippocampal-mediated HPA feedback (p=.039).
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we measured plasma oxytocin levels at intervals before and after stress induction in six polydipsic hyponatremic (PHS), four polydipsic normonatremic (PNS), five nonpolydipsic normonatremic schizophrenic (NNS) patients and seven healthy controls.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1796198805
06HumanEndogenous levelObservational studyOther
Plasma oxytocin levels predicted schizophrenic patients' ability to correctly identify facial emotions.
In plain wordsIn people with schizophrenia, the body's own oxytocin levels in blood predicted how well they identified facial emotions.
Peptide
Oxytocin
Outcome
Not applicableOxytocin and facial emotion identification
Study
n: not reported in source
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
Finally, 4) oxytocin levels predicted schizophrenic patients' ability to correctly identify facial emotions (p=.004).
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we measured plasma oxytocin levels at intervals before and after stress induction in six polydipsic hyponatremic (PHS), four polydipsic normonatremic (PNS), five nonpolydipsic normonatremic schizophrenic (NNS) patients and seven healthy controls.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1796198806

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · 1 with posted results · source ClinicalTrials.gov (opens in a new tab)

CompletedNot applicableResults postedNCT01312272

Does Acute Oxytocin Administration Enhance Social Cognition in Individuals With Schizophrenia?

VA Greater Los Angeles Healthcare Systemn = 24Apr 2011 to Aug 2012

Schizophrenia

Trial page ClinicalTrials.govUpdated 2 May 2014

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 01:30 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

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