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Study · In vitro (cells) · 2008

2 results

Melanocytes expressing MC1R polymorphisms associated with red hair color have altered MSH-ligand activated pigmentary responses in coculture with keratinocytes.

Roberts DW, Newton RA, Leonard JH, Sturm RA

Journal of cellular physiology1 May 2008Cited by 18 (Europe PMC)

PMID17960564 (opens in a new tab)DOI10.1002/jcp.21318 (opens in a new tab)PepBankPUB-17960564
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In a human melanocyte-keratinocyte coculture, NDP-MSH enhanced the dendricity response markedly more in wild-type melanocytes than in melanocytes with MC1R red hair color variants.

    In plain wordsIn lab cell cultures, NDP-MSH changed pigment cell shape much more in normal cells than in cells with red hair gene variants.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseDendricity response to NDP-MSH
    Study

    humann: not reported in source

    Serum-free melanocyte-keratinocyte coculture
    Comparator
    Wild-type melanocytes versus MC1R red hair color variant melanocytes
    Outcome group
    Pigmentation · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, the dendricity response following agonist activation of the MC1R receptor by NDP-MSH peptide, was markedly enhanced in WT melanocytes in comparison to RHC strains.
    1 context sentence
    Summary · context
    We have established a serum free human melanocyte-keratinocyte coculture system to study the behavior and functional abilities of melanocytes expressing MC1R red hair color (RHC) variants in order to identify differences from their wild type (WT) counterparts.
  2. 02LabIn vitro (cells)Mechanism

    In a human melanocyte-keratinocyte coculture, NDP-MSH increased dopachrome tautomerase mRNA and protein preferentially in wild-type cocultures, with a negligible or much reduced response in red hair color variant melanocytes.

    In plain wordsIn lab cell cultures, NDP-MSH raised an enzyme needed for pigment mainly in normal cells, and much less in cells with red hair gene variants.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseDopachrome tautomerase expression after NDP-MSH
    Study

    humann: not reported in source

    Serum-free melanocyte-keratinocyte coculture
    Comparator
    Wild-type melanocytes versus MC1R red hair color variant melanocytes
    Outcome group
    Pigmentation · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Analysis of mRNA expression and protein levels of the major pigmentation markers following NDP-MSH treatment distinguished the enzyme dopachrome tautomerase as preferentially upregulated in cocultures of WT strains, with negligible or a much reduced response in melanocytes with RHC variant alleles.
    1 context sentence
    Summary · context
    We have established a serum free human melanocyte-keratinocyte coculture system to study the behavior and functional abilities of melanocytes expressing MC1R red hair color (RHC) variants in order to identify differences from their wild type (WT) counterparts.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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