Skip to content

Study · Animal study (in vivo) · mouse · 2008

11 results

Activation of somatostatin receptors attenuates pulmonary fibrosis.

Borie R, Fabre A, Prost F, Marchal-Somme J, Lebtahi R, Marchand-Adam S, Aubier M, Soler P, Crestani B

Thorax19 Oct 2007Cited by 49 (Europe PMC)

PMID17951277 (opens in a new tab)DOI10.1136/thx.2007.078006 (opens in a new tab)PepBankPUB-17951277
Source linkPubMedAsk about this study
Jump to 11 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with bleomycin-induced fibrosis, pasireotide increased survival to 69% versus 44% with saline, p = 0.024.

    In plain wordsIn mice with bleomycin-induced fibrosis, pasireotide increased survival compared with saline.

    Peptide
    Pasireotide
    Outcome
    IncreaseSurvival
    Study

    mousen: not reported in source

    bleomycin-induced lung fibrosis in C57Bl6 male mice
    Comparator
    saline
    Outcome group
    Mortality · Respiratory
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    SOM230 improved mice survival (69% vs 44%; p = 0.024), reduced lung collagen content at day 14 and decreased lung collagen-1 mRNA at day 7.
    2 context sentences
    Summary · context
    After intratracheal injection of bleomycin, C57Bl6 male mice received one daily subcutaneous injection of SOM230 or saline.
    Summary · context
    The lungs were evaluated on days 3, 7 and 14 after administration of bleomycin.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with bleomycin-induced fibrosis, pasireotide reduced lung collagen content at day 14 versus saline.

    In plain wordsIn mice with bleomycin-induced fibrosis, pasireotide reduced lung collagen at day 14 compared with saline.

    Peptide
    Pasireotide
    Outcome
    DecreaseLung collagen content
    Study

    mousen: not reported in source

    bleomycin-induced lung fibrosis in C57Bl6 male mice
    Comparator
    saline
    Outcome group
    Pulmonary fibrosis · Respiratory
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    SOM230 improved mice survival (69% vs 44%; p = 0.024), reduced lung collagen content at day 14 and decreased lung collagen-1 mRNA at day 7.
    2 context sentences
    Summary · context
    After intratracheal injection of bleomycin, C57Bl6 male mice received one daily subcutaneous injection of SOM230 or saline.
    Summary · context
    The lungs were evaluated on days 3, 7 and 14 after administration of bleomycin.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with bleomycin-induced fibrosis, pasireotide decreased lung collagen-1 mRNA at day 7 versus saline.

    In plain wordsIn mice with bleomycin-induced fibrosis, pasireotide reduced lung collagen-1 mRNA at day 7 compared with saline.

    Peptide
    Pasireotide
    Outcome
    DecreaseLung collagen-1 mRNA
    Study

    mousen: not reported in source

    bleomycin-induced lung fibrosis in C57Bl6 male mice
    Comparator
    saline
    Outcome group
    Pulmonary fibrosis · Respiratory
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    SOM230 improved mice survival (69% vs 44%; p = 0.024), reduced lung collagen content at day 14 and decreased lung collagen-1 mRNA at day 7.
    2 context sentences
    Summary · context
    After intratracheal injection of bleomycin, C57Bl6 male mice received one daily subcutaneous injection of SOM230 or saline.
    Summary · context
    The lungs were evaluated on days 3, 7 and 14 after administration of bleomycin.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with bleomycin-induced fibrosis, pasireotide reduced bronchoalveolar lavage inflammatory cell influx at day 3 versus saline.

    In plain wordsIn mice with bleomycin-induced fibrosis, pasireotide reduced lung inflammatory cell influx at day 3 compared with saline.

    Peptide
    Pasireotide
    Outcome
    DecreaseInflammatory cell influx
    Study

    mousen: not reported in source

    bleomycin-induced lung fibrosis in C57Bl6 male mice
    Comparator
    saline
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    SOM230 reduced bronchoalveolar lavage inflammatory cell influx at day 3, decreased lung connective tissue growth factor mRNA and transforming growth factor (TGF) beta mRNA and increased lung hepatocyte growth factor and keratinocyte growth factor mRNA.
    2 context sentences
    Summary · context
    After intratracheal injection of bleomycin, C57Bl6 male mice received one daily subcutaneous injection of SOM230 or saline.
    Summary · context
    The lungs were evaluated on days 3, 7 and 14 after administration of bleomycin.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with bleomycin-induced fibrosis, pasireotide decreased lung connective tissue growth factor mRNA versus saline.

    In plain wordsIn mice with bleomycin-induced fibrosis, pasireotide reduced lung connective tissue growth factor mRNA compared with saline.

    Peptide
    Pasireotide
    Outcome
    DecreaseConnective tissue growth factor mRNA
    Study

    mousen: not reported in source

    bleomycin-induced lung fibrosis in C57Bl6 male mice
    Comparator
    saline
    Outcome group
    Pulmonary fibrosis · Respiratory
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    SOM230 reduced bronchoalveolar lavage inflammatory cell influx at day 3, decreased lung connective tissue growth factor mRNA and transforming growth factor (TGF) beta mRNA and increased lung hepatocyte growth factor and keratinocyte growth factor mRNA.
    2 context sentences
    Summary · context
    After intratracheal injection of bleomycin, C57Bl6 male mice received one daily subcutaneous injection of SOM230 or saline.
    Summary · context
    The lungs were evaluated on days 3, 7 and 14 after administration of bleomycin.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with bleomycin-induced fibrosis, pasireotide decreased lung TGF beta mRNA versus saline.

    In plain wordsIn mice with bleomycin-induced fibrosis, pasireotide reduced lung TGF beta mRNA compared with saline.

    Peptide
    Pasireotide
    Outcome
    DecreaseTGF beta mRNA
    Study

    mousen: not reported in source

    bleomycin-induced lung fibrosis in C57Bl6 male mice
    Comparator
    saline
    Outcome group
    Pulmonary fibrosis · Respiratory
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    SOM230 reduced bronchoalveolar lavage inflammatory cell influx at day 3, decreased lung connective tissue growth factor mRNA and transforming growth factor (TGF) beta mRNA and increased lung hepatocyte growth factor and keratinocyte growth factor mRNA.
    2 context sentences
    Summary · context
    After intratracheal injection of bleomycin, C57Bl6 male mice received one daily subcutaneous injection of SOM230 or saline.
    Summary · context
    The lungs were evaluated on days 3, 7 and 14 after administration of bleomycin.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice with bleomycin-induced fibrosis, pasireotide increased lung hepatocyte growth factor mRNA versus saline.

    In plain wordsIn mice with bleomycin-induced fibrosis, pasireotide increased lung hepatocyte growth factor mRNA compared with saline.

    Peptide
    Pasireotide
    Outcome
    IncreaseHepatocyte growth factor mRNA
    Study

    mousen: not reported in source

    bleomycin-induced lung fibrosis in C57Bl6 male mice
    Comparator
    saline
    Outcome group
    Pulmonary fibrosis · Respiratory
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    SOM230 reduced bronchoalveolar lavage inflammatory cell influx at day 3, decreased lung connective tissue growth factor mRNA and transforming growth factor (TGF) beta mRNA and increased lung hepatocyte growth factor and keratinocyte growth factor mRNA.
    2 context sentences
    Summary · context
    After intratracheal injection of bleomycin, C57Bl6 male mice received one daily subcutaneous injection of SOM230 or saline.
    Summary · context
    The lungs were evaluated on days 3, 7 and 14 after administration of bleomycin.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In mice with bleomycin-induced fibrosis, pasireotide increased lung keratinocyte growth factor mRNA versus saline.

    In plain wordsIn mice with bleomycin-induced fibrosis, pasireotide increased lung keratinocyte growth factor mRNA compared with saline.

    Peptide
    Pasireotide
    Outcome
    IncreaseKeratinocyte growth factor mRNA
    Study

    mousen: not reported in source

    bleomycin-induced lung fibrosis in C57Bl6 male mice
    Comparator
    saline
    Outcome group
    Pulmonary fibrosis · Respiratory
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    SOM230 reduced bronchoalveolar lavage inflammatory cell influx at day 3, decreased lung connective tissue growth factor mRNA and transforming growth factor (TGF) beta mRNA and increased lung hepatocyte growth factor and keratinocyte growth factor mRNA.
    2 context sentences
    Summary · context
    After intratracheal injection of bleomycin, C57Bl6 male mice received one daily subcutaneous injection of SOM230 or saline.
    Summary · context
    The lungs were evaluated on days 3, 7 and 14 after administration of bleomycin.
  9. 09LabIn vitro (cells)Efficacy outcome

    In human lung fibroblasts under basal conditions, pasireotide reduced BrdU incorporation.

    In plain wordsIn cells from human lungs under basal conditions, pasireotide reduced BrdU incorporation compared with untreated cells.

    Peptide
    Pasireotide
    Outcome
    DecreaseBasal fibroblast BrdU incorporation
    Study

    humann: not reported in source

    human lung fibroblasts under basal conditions
    Comparator
    basal conditions without SOM230
    Outcome group
    Pulmonary fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, SOM230 reduced BrdU incorporation by control human lung fibroblasts cultured under basal conditions or with TGFbeta, and reduced alpha-1 collagen-1 mRNA expression in TGFbeta stimulated fibroblasts.
  10. 10LabIn vitro (cells)Efficacy outcome

    In TGFbeta-stimulated human lung fibroblasts, pasireotide reduced BrdU incorporation.

    In plain wordsIn cells from human lungs, pasireotide reduced BrdU incorporation compared with TGFbeta alone.

    Peptide
    Pasireotide
    Outcome
    DecreaseTGFbeta-stimulated fibroblast BrdU incorporation
    Study

    humann: not reported in source

    TGFbeta-stimulated human lung fibroblasts
    Comparator
    TGFbeta without SOM230
    Outcome group
    Pulmonary fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, SOM230 reduced BrdU incorporation by control human lung fibroblasts cultured under basal conditions or with TGFbeta, and reduced alpha-1 collagen-1 mRNA expression in TGFbeta stimulated fibroblasts.
  11. 11LabIn vitro (cells)Efficacy outcome

    In TGFbeta-stimulated human lung fibroblasts, pasireotide reduced alpha-1 collagen-1 mRNA expression.

    In plain wordsIn cells from human lungs, pasireotide reduced alpha-1 collagen-1 mRNA compared with TGFbeta alone.

    Peptide
    Pasireotide
    Outcome
    DecreaseFibroblast alpha-1 collagen-1 mRNA
    Study

    humann: not reported in source

    TGFbeta-stimulated human lung fibroblasts
    Comparator
    TGFbeta without SOM230
    Outcome group
    Pulmonary fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, SOM230 reduced BrdU incorporation by control human lung fibroblasts cultured under basal conditions or with TGFbeta, and reduced alpha-1 collagen-1 mRNA expression in TGFbeta stimulated fibroblasts.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:34 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.