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Study · Animal study (in vivo) · 2007

3 results

Neuroprotective effects of thymosin beta4 in experimental models of excitotoxicity.

Popoli P, Pepponi R, Martire A, Armida M, Pèzzola A, Galluzzo M, Domenici MR, Potenza RL, Tebano MT, Mollinari C, Merlo D, Garaci E

Annals of the New York Academy of Sciences1 Sept 2007Cited by 29 (Europe PMC)

PMID17947590 (opens in a new tab)DOI10.1196/annals.1415.033 (opens in a new tab)PepBankPUB-17947590
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In animals given kainic acid, intracerebroventricular thymosin beta‑4 significantly reduced hippocampal neuronal loss.

    In plain wordsIn animals given kainic acid, thymosin beta‑4 injected into the brain reduced loss of hippocampal neurons.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseHippocampal neuronal loss after kainic acid
    Study

    n: not reported in source

    kainic acid excitotoxicity
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study.

    Source sentences

    Summary
    In in vivo experiments, the intracerebroventricular administration of thymosin beta(4) significantly reduced hippocampal neuronal loss induced by kainic acid.
  2. 02LabEx vivo tissueEfficacy outcome

    In rat hippocampal slices, thymosin beta‑4 significantly attenuated glutamate-induced toxicity.

    In plain wordsIn rat brain slices, thymosin beta‑4 reduced damage caused by glutamate.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseGlutamate-induced toxicity in hippocampal slices
    Study

    ratn: not reported in source

    hippocampal slices
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The application of thymosin beta(4) significantly attenuated glutamate-induced toxicity both in primary cultures of cortical neurons and in rat hippocampal slices.
  3. 03LabIn vitro (cells)Efficacy outcome

    In primary cultures of cortical neurons, thymosin beta‑4 significantly attenuated glutamate-induced toxicity.

    In plain wordsIn cultured neurons, thymosin beta‑4 reduced damage caused by glutamate.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseGlutamate-induced toxicity in cortical neurons
    Study

    n: not reported in source

    primary cultures of cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The application of thymosin beta(4) significantly attenuated glutamate-induced toxicity both in primary cultures of cortical neurons and in rat hippocampal slices.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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