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Study · Animal study (in vivo) · rat · 2008

3 results

Hypothalamic gene expression following ghrelin therapy to gastrectomized rodents.

Egecioglu E, Stenström B, Pinnock SB, Tung LY, Dornonville de la Cour C, Lindqvist A, Håkanson R, Syversen U, Chen D, Dickson SL

Regulatory peptides14 Sept 2007Cited by 10 (Europe PMC)

PMID17936372 (opens in a new tab)DOI10.1016/j.regpep.2007.09.006 (opens in a new tab)PepBankPUB-17936372
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, two weeks of MK-0677 gavage increased arcuate nucleus NPY mRNA.

    In plain wordsIn rats, MK-0677 increased NPY gene expression in the arcuate nucleus.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    IncreaseArcuate nucleus NPY mRNA
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · gavage · Two weeksAs given in this study (rat).

    Source sentences

    Summary
    Two weeks gavage treatment with the ghrelin mimetic, MK-0677, to rats increased NPY and POMC mRNA in the arcuate nucleus and MCH mRNA in the lateral hypothalamus.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, two weeks of MK-0677 gavage increased arcuate nucleus POMC mRNA.

    In plain wordsIn rats, MK-0677 increased POMC gene expression in the arcuate nucleus.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    IncreaseArcuate nucleus POMC mRNA
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · gavage · Two weeksAs given in this study (rat).

    Source sentences

    Summary
    Two weeks gavage treatment with the ghrelin mimetic, MK-0677, to rats increased NPY and POMC mRNA in the arcuate nucleus and MCH mRNA in the lateral hypothalamus.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, two weeks of MK-0677 gavage increased lateral hypothalamic MCH mRNA.

    In plain wordsIn rats, MK-0677 increased MCH gene expression in the lateral hypothalamus.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    IncreaseLateral hypothalamic MCH mRNA
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · gavage · Two weeksAs given in this study (rat).

    Source sentences

    Summary
    Two weeks gavage treatment with the ghrelin mimetic, MK-0677, to rats increased NPY and POMC mRNA in the arcuate nucleus and MCH mRNA in the lateral hypothalamus.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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