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Study · Not a test of the peptide alone · 2007

2 results

Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations.

Moulin A, Demange L, Bergé G, Gagne D, Ryan J, Mousseaux D, Heitz A, Perrissoud D, Locatelli V, Torsello A, Galleyrand JC, Fehrentz JA, Martinez J

Journal of medicinal chemistry10 Oct 2007Cited by 106 (Europe PMC)

PMID17927165 (opens in a new tab)DOI10.1021/jm0704550 (opens in a new tab)PepBankPUB-17927165
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

  1. 01AnimalNot a test of Hexarelin aloneAnimal study (in vivo)Efficacy outcome

    In rodents, triazole ghrelin receptor ligands JMV2959, compound 17 and JMV3021 acted as potent antagonists of hexarelin-stimulated food intake.

    In plain wordsIn rodents, three new test compounds blocked the extra eating that hexarelin caused. The result is about the compounds, not hexarelin.

    Peptide
    Hexarelin
    Outcome
    DecreaseHexarelin-stimulated food intake
    Study

    rodentn: not reported in source

    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    Among the tested compounds, few of them were able to stimulate food intake and some others, i.e., compounds 4 (JMV2959), 17, and 52 (JMV3021), acted as potent in vivo antagonist of hexarelin-stimulated food intake.
    1 context sentence
    Summary · context
    The best compounds were evaluated for their in vivo activity on food intake, after sc injection in rodents.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  2. 02AnimalNot a test of Hexarelin aloneAnimal study (in vivo)Efficacy outcome

    In rats, the triazole ghrelin receptor ligands did not antagonize growth hormone secretion induced by hexarelin.

    In plain wordsIn rats, the test compounds did not block the growth hormone release that hexarelin caused. The result is about the compounds, not hexarelin.

    Peptide
    Hexarelin
    Outcome
    No significant changeHexarelin-induced growth hormone secretion
    Study

    ratn: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    These compounds did not stimulate growth hormone secretion in rats and furthermore did not antagonize growth hormone secretion induced by hexarelin, revealing that it is possible to modulate food intake without altering growth hormone secretion.
    1 context sentence
    Summary · context
    The best compounds were evaluated for their in vivo activity on food intake, after sc injection in rodents.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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