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Study · Animal study (in vivo) · mouse · 2007

4 results

Recombinant thymosin beta 4 can promote full-thickness cutaneous wound healing.

Li X, Zheng L, Peng F, Qi C, Zhang X, Zhou A, Liu Z, Wu S

Protein expression and purification4 Sept 2007Cited by 30 (Europe PMC)

PMID17923415 (opens in a new tab)DOI10.1016/j.pep.2007.08.011 (opens in a new tab)PepBankPUB-17923415
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In BALB/c mice, recombinant human thymosin beta‑4 promoted full-thickness cutaneous wound healing.

    In plain wordsIn mice, recombinant human thymosin beta‑4 helped full-thickness skin wounds heal.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseFull-thickness cutaneous wound healing
    Study

    mousen: not reported in source

    full-thickness cutaneous wound
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Further, it can also promote full-thickness cutaneous wound healing in BALB/c mice.
    1 context sentence
    Summary · context
    After the fusion tag was removed from the fusion protein through autohydrolysis by dithiothreitol (DTT), the biological activity and function of this recombinant human TB4 was evaluated by cell proliferation assay using prepared spleen cells and wound assay using a mouse model, respectively.
  2. 02LabIn vitro (cells)Efficacy outcome

    In spleen cells, recombinant human thymosin beta‑4 promoted lymphocyte proliferation.

    In plain wordsIn cells, recombinant human thymosin beta‑4 increased the growth of lymphocytes.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseLymphocyte proliferation
    Study

    n: not reported in source

    spleen cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    human recombinant TB4 can promote lymphocyte proliferation and differentiation.
    1 context sentence
    Summary · context
    After the fusion tag was removed from the fusion protein through autohydrolysis by dithiothreitol (DTT), the biological activity and function of this recombinant human TB4 was evaluated by cell proliferation assay using prepared spleen cells and wound assay using a mouse model, respectively.
  3. 03LabIn vitro (cells)Efficacy outcome

    In spleen cells, recombinant human thymosin beta‑4 promoted lymphocyte differentiation.

    In plain wordsIn cells, recombinant human thymosin beta‑4 promoted the maturing of lymphocytes.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseLymphocyte differentiation
    Study

    n: not reported in source

    spleen cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    human recombinant TB4 can promote lymphocyte proliferation and differentiation.
    1 context sentence
    Summary · context
    After the fusion tag was removed from the fusion protein through autohydrolysis by dithiothreitol (DTT), the biological activity and function of this recombinant human TB4 was evaluated by cell proliferation assay using prepared spleen cells and wound assay using a mouse model, respectively.

Studies that did not test the peptide alone1

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 04LabNot a test of Thymosin beta-4 (human) aloneOther designOther

    Human thymosin beta‑4 was cloned and overexpressed in an Escherichia coli system and purified from the fusion protein by a one-step affinity method.

    In plain wordsIn lab work, human thymosin beta‑4 was made in bacteria and purified in one affinity step.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableRecombinant production and purification
    Study

    n: not reported in source

    Escherichia coli expression system
    Outcome group
    Synthesis and manufacturing · Pharmacology

    Source sentences

    Summary
    In order to obtain sufficient biologically active human TB4 economically, we cloned and overexpressed this protein in an Escherichia coli system. We also developed a one-step affinity purification method to purify this fusion protein.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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