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Study · Animal study (in vivo) · rat · 2007

2 results

Central administration of selective melanocortin 4 receptor antagonist HS014 prevents morphine tolerance and withdrawal hyperalgesia.

Kalange AS, Kokare DM, Singru PS, Upadhya MA, Chopde CT, Subhedar NK

Brain research4 Sept 2007Cited by 41 (Europe PMC)

PMID17915196 (opens in a new tab)DOI10.1016/j.brainres.2007.08.054 (opens in a new tab)PepBankPUB-17915196
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, a subeffective dose of NDP-MSH antagonized the antinociceptive activity of acute intracerebroventricular morphine in the tail flick test.

    In plain wordsIn rats, a small dose of NDP-MSH weakened the pain-blocking effect of morphine.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseMorphine antinociception with subeffective NDP-MSH
    Study

    ratn: not reported in source

    Tail flick test with icv morphine
    Comparator
    Morphine alone
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    0.04 ng/rat · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Acute intracerebroventricular (icv) administration of morphine (2-20 microg/rat) exhibited antinociceptive activity, which was antagonized by subeffective dose of nonselective MC R agonist NDP-MSH (0.04 ng/rat, icv), and potentiated by subeffective dose of MC4 R antagonist HS014 (0.008 ng/rat, icv).
    1 context sentence
    Summary · context
    We investigated the role of central MC4 R in acute, chronic effects and withdrawal reactions of morphine using tail flick test.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, isobolographic analysis showed an antagonistic interaction between NDP-MSH and morphine.

    In plain wordsIn rats, NDP-MSH and morphine worked against each other in the tail flick test.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableIsobolographic interaction of NDP-MSH and morphine
    Study

    ratn: not reported in source

    Tail flick test with icv morphine
    Comparator
    Morphine alone
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Isobolographic analysis revealed antagonistic interaction between NDP-MSH and morphine, and additive interaction between HS014 and morphine combinations.
    1 context sentence
    Summary · context
    We investigated the role of central MC4 R in acute, chronic effects and withdrawal reactions of morphine using tail flick test.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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