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Study · Randomized controlled trial · n = 52 · 2008

2 results

Oxytocin increases gaze to the eye region of human faces.

Guastella AJ, Mitchell PB, Dadds MR

Biological psychiatry21 Sept 2007Cited by 538 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy men, intranasal oxytocin increased the number of fixations toward the eye region of faces versus placebo.

    In plain wordsIn healthy men, oxytocin led to more eye fixations on the eye region of faces than placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseNumber of fixations toward the eye region
    Study

    n = 52

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Participants given oxytocin showed an increased number of fixations and total gaze time toward the eye region compared with placebo participants.
    1 context sentence
    Summary · context
    In a double-blind, randomized, placebo-controlled, between-subject design, we tracked the eye movements of 52 healthy male volunteers who were presented with 24 neutral human faces after intranasal administration of 24 IU oxytocin or placebo.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy men, intranasal oxytocin increased total gaze time toward the eye region of faces versus placebo.

    In plain wordsIn healthy men, oxytocin led to more gaze time on the eye region of faces than placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseTotal gaze time toward the eye region
    Study

    n = 52

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Participants given oxytocin showed an increased number of fixations and total gaze time toward the eye region compared with placebo participants.
    1 context sentence
    Summary · context
    In a double-blind, randomized, placebo-controlled, between-subject design, we tracked the eye movements of 52 healthy male volunteers who were presented with 24 neutral human faces after intranasal administration of 24 IU oxytocin or placebo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials4

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

4 trials · 4 completed · 2 with posted results · source ClinicalTrials.gov (opens in a new tab)

CompletedEarly phase 1NCT03211013

Study of the Effects of Oxytocin on Attentional Bias and Startle in PTSD

Palo Alto Veterans Institute for Researchn = 1710 Jul 2017 to 9 Jun 2021

Posttraumatic Stress Disorder

Trial pageClinicalTrials.govUpdated 10 Jun 2021
CompletedPhase 2Results postedNCT01568528

Oxytocin as Adjunctive Treatment of Schizophrenia

Emory Universityn = 39Mar 2013 to 15 Mar 2017

Schizophrenia

Trial pageClinicalTrials.govUpdated 4 Sept 2019
CompletedNot applicableResults postedNCT01312272

Does Acute Oxytocin Administration Enhance Social Cognition in Individuals With Schizophrenia?

VA Greater Los Angeles Healthcare Systemn = 24Apr 2011 to Aug 2012

Schizophrenia

CompletedNot applicableNCT01002300

Oxytocin and Social Cognition in Frontotemporal Dementia

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sn = 24Sept 2009 to Nov 2010

Frontotemporal Dementia · Pick's Disease

Trial pageClinicalTrials.govUpdated 18 Mar 2014

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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