Skip to content

Study · Ex vivo tissue · rat · 2008

10 results

Transformation products of extracellular NAD(+) in the rat liver: kinetics of formation and metabolic action.

Broetto-Biazon AC, Bracht F, de Sá-Nakanishi AB, Lopez CH, Constantin J, Kelmer-Bracht AM, Bracht A

Molecular and cellular biochemistry12 Sept 2007Cited by 8 (Europe PMC)

PMID17846864 (opens in a new tab)DOI10.1007/s11010-007-9582-7 (opens in a new tab)PepBankPUB-17846864
Publisher pagePubMedAsk about this study
Jump to 10 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissuePharmacokinetics

    In perfused rat liver, single-pass NAD transformation ranged from 75% at 1.5 min to 95% at 8 min.

    In plain wordsIn lab tests with rat liver, NAD transformation increased from 75% at 1.5 min to 95% at 8 min.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseSingle-pass NAD transformation
    Study

    ratn: not reported in source

    Isolated perfused rat liver
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    100 microMAs given in this study (rat).

    Measurements

    Single-pass transformation
    75%
    1.5 min
    Single-pass transformation
    95%
    8 min

    Source sentences

    Summary
    Confirming previous findings, the single-pass transformation of 100 microM NAD(+) ranged between 75% at 1.5 min after starting infusion to 95% at 8 min.
    2 context sentences
    Summary · context
    The experiments were done with the isolated perfused rat liver.
    Summary · context
    The NAD(+) transformation was monitored by HPLC.
  2. 02LabEx vivo tissuePharmacokinetics

    In perfused rat liver, nicotinamide was a major extracellular NAD transformation product in the outflowing perfusate.

    In plain wordsIn lab tests with rat liver, nicotinamide was a major product of extracellular NAD transformation.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Not applicableNicotinamide transformation product
    Study

    ratn: not reported in source

    Isolated perfused rat liver
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The most important products of single-pass NAD(+) transformation appearing in the outflowing perfusate were nicotinamide, ADP-ribose, uric acid, and inosine.
    2 context sentences
    Summary · context
    The experiments were done with the isolated perfused rat liver.
    Summary · context
    The NAD(+) transformation was monitored by HPLC.
  3. 03LabEx vivo tissuePharmacokinetics

    In perfused rat liver, ADP-ribose was a major extracellular NAD transformation product in the outflowing perfusate.

    In plain wordsIn lab tests with rat liver, ADP-ribose was a major product of extracellular NAD transformation.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Not applicableADP-ribose transformation product
    Study

    ratn: not reported in source

    Isolated perfused rat liver
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The most important products of single-pass NAD(+) transformation appearing in the outflowing perfusate were nicotinamide, ADP-ribose, uric acid, and inosine.
    2 context sentences
    Summary · context
    The experiments were done with the isolated perfused rat liver.
    Summary · context
    The NAD(+) transformation was monitored by HPLC.
  4. 04LabEx vivo tissuePharmacokinetics

    In perfused rat liver, uric acid was a major extracellular NAD transformation product in the outflowing perfusate.

    In plain wordsIn lab tests with rat liver, uric acid was a major product of extracellular NAD transformation.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Not applicableUric acid transformation product
    Study

    ratn: not reported in source

    Isolated perfused rat liver
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The most important products of single-pass NAD(+) transformation appearing in the outflowing perfusate were nicotinamide, ADP-ribose, uric acid, and inosine.
    2 context sentences
    Summary · context
    The experiments were done with the isolated perfused rat liver.
    Summary · context
    The NAD(+) transformation was monitored by HPLC.
  5. 05LabEx vivo tissuePharmacokinetics

    In perfused rat liver, inosine was a major extracellular NAD transformation product in the outflowing perfusate.

    In plain wordsIn lab tests with rat liver, inosine was a major product of extracellular NAD transformation.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Not applicableInosine transformation product
    Study

    ratn: not reported in source

    Isolated perfused rat liver
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The most important products of single-pass NAD(+) transformation appearing in the outflowing perfusate were nicotinamide, ADP-ribose, uric acid, and inosine.
    2 context sentences
    Summary · context
    The experiments were done with the isolated perfused rat liver.
    Summary · context
    The NAD(+) transformation was monitored by HPLC.
  6. 06LabEx vivo tissuePharmacokinetics

    In perfused rat liver, NAD transformation product proportions varied with infusion time and perfusion conditions.

    In plain wordsIn lab tests with rat liver, NAD transformation product proportions varied with infusion time and perfusion conditions.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    MixedProduct proportions over time and conditions
    Study

    ratn: not reported in source

    Isolated perfused rat liver
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The relative proportions of these products presented some variations with the time after initiation of NAD(+) infusion and the perfusion conditions, but ADP-ribose was always more abundant than uric acid and inosine.
    2 context sentences
    Summary · context
    The experiments were done with the isolated perfused rat liver.
    Summary · context
    The NAD(+) transformation was monitored by HPLC.
  7. 07LabEx vivo tissuePharmacokinetics

    In perfused rat liver, NAD-derived ADP-ribose was always more abundant than uric acid.

    In plain wordsIn lab tests with rat liver, NAD-derived ADP-ribose was always more abundant than uric acid.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseADP-ribose abundance versus uric acid
    Study

    ratn: not reported in source

    Isolated perfused rat liver
    Comparator
    Uric acid
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The relative proportions of these products presented some variations with the time after initiation of NAD(+) infusion and the perfusion conditions, but ADP-ribose was always more abundant than uric acid and inosine.
    2 context sentences
    Summary · context
    The experiments were done with the isolated perfused rat liver.
    Summary · context
    The NAD(+) transformation was monitored by HPLC.
  8. 08LabEx vivo tissuePharmacokinetics

    In perfused rat liver, NAD-derived ADP-ribose was always more abundant than inosine.

    In plain wordsIn lab tests with rat liver, NAD-derived ADP-ribose was always more abundant than inosine.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseADP-ribose abundance versus inosine
    Study

    ratn: not reported in source

    Isolated perfused rat liver
    Comparator
    Inosine
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The relative proportions of these products presented some variations with the time after initiation of NAD(+) infusion and the perfusion conditions, but ADP-ribose was always more abundant than uric acid and inosine.
    2 context sentences
    Summary · context
    The experiments were done with the isolated perfused rat liver.
    Summary · context
    The NAD(+) transformation was monitored by HPLC.
  9. 09LabEx vivo tissuePharmacokinetics

    In perfused rat liver, cyclic ADP-ribose was not detected in the outflowing perfusate after NAD infusion.

    In plain wordsIn lab tests with rat liver, cyclic ADP-ribose was not detected in the perfusate after NAD infusion.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Not applicableCyclic ADP-ribose detection
    Study

    ratn: not reported in source

    Isolated perfused rat liver
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cyclic ADP-ribose (cADP-ribose) as well as adenosine were not detected in the outflowing perfusate.
    2 context sentences
    Summary · context
    The experiments were done with the isolated perfused rat liver.
    Summary · context
    The NAD(+) transformation was monitored by HPLC.
  10. 10LabEx vivo tissuePharmacokinetics

    In perfused rat liver, adenosine was not detected in the outflowing perfusate after NAD infusion.

    In plain wordsIn lab tests with rat liver, adenosine was not detected in the perfusate after NAD infusion.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Not applicableAdenosine detection
    Study

    ratn: not reported in source

    Isolated perfused rat liver
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cyclic ADP-ribose (cADP-ribose) as well as adenosine were not detected in the outflowing perfusate.
    2 context sentences
    Summary · context
    The experiments were done with the isolated perfused rat liver.
    Summary · context
    The NAD(+) transformation was monitored by HPLC.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.