Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease.

Bertilsson G, Patrone C, Zachrisson O, Andersson A, Dannaeus K, Heidrich J, Kortesmaa J, Mercer A, Nielsen E, Rönnholm H, Wikström L

Journal of neuroscience research1 Feb 2008Cited by 298 (Europe PMC)

PMID17803225DOI10.1002/jnr.21483PepBankPUB-17803225

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In naive rodents, exendin‑4 increased bromodeoxyuridine-positive cells after administration with the DNA synthesis marker.
In plain wordsIn rodents, exendin‑4 increased cells positive for a DNA synthesis marker.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseBromodeoxyuridine-positive cells
Study
rodentn: not reported in source
Naive rodents
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intraperitonealAs given in this study (rodent).
Source sentences
Summary
When exendin-4 was given intraperitoneally to naïve rodents together with bromodeoxyuridine, a marker for DNA synthesis, both the number of bromodeoxyuridine-positive cells and the number of neuronal precursor cells expressing doublecortin were increased.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the effects of exendin-4 on neural stem/progenitor cells in the subventricular zone of the adult rodent brain and its functional effects in an animal model of Parkinson's disease.
Report a problemFND-1780322503
02AnimalAnimal study (in vivo)Efficacy outcome
In naive rodents, exendin‑4 increased doublecortin-positive neuronal precursor cells.
In plain wordsIn rodents, exendin‑4 increased neuronal precursor cells positive for doublecortin.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseDoublecortin-positive neuronal precursor cells
Study
rodentn: not reported in source
Naive rodents
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intraperitonealAs given in this study (rodent).
Source sentences
Summary
When exendin-4 was given intraperitoneally to naïve rodents together with bromodeoxyuridine, a marker for DNA synthesis, both the number of bromodeoxyuridine-positive cells and the number of neuronal precursor cells expressing doublecortin were increased.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the effects of exendin-4 on neural stem/progenitor cells in the subventricular zone of the adult rodent brain and its functional effects in an animal model of Parkinson's disease.
Report a problemFND-1780322504
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with a Parkinson's disease lesion model, exendin‑4 reduced amphetamine-induced rotations, with effects persisting after treatment ended.
In plain wordsIn rats with a Parkinson's disease model, exendin‑4 reduced drug-induced rotations, and the effect continued after treatment ended.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseAmphetamine-induced rotations
Study
ratn: not reported in source
6-hydroxydopamine model of Parkinson's disease
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 3 weeksAs given in this study (rat).
Source sentences
Summary
We found a reduction of amphetamine-induced rotations in animals receiving exendin-4 that persisted for several weeks after drug administration had been terminated.
3 context sentences(design, population, supporting numbers)
Summary · context
Exendin-4 was tested in the 6-hydroxydopamine model of Parkinson's disease to investigate its possible functional effects in an animal model with neuronal loss.
Summary · context
After unilateral lesion and a 5-week stabilization period, the rats were treated for 3 weeks with exendin-4.
Summary · context
We investigated the effects of exendin-4 on neural stem/progenitor cells in the subventricular zone of the adult rodent brain and its functional effects in an animal model of Parkinson's disease.
Report a problemFND-1780322505
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with a Parkinson's disease model, exendin‑4 increased tyrosine hydroxylase-positive neurons in the substantia nigra.
In plain wordsIn rats with a Parkinson's disease model, exendin‑4 increased neurons positive for tyrosine hydroxylase.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseTyrosine hydroxylase-positive neurons
Study
ratn: not reported in source
6-hydroxydopamine model of Parkinson's disease
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 3 weeksAs given in this study (rat).
Source sentences
Summary
Histological analysis showed that exendin-4 significantly increased the number of both tyrosine hydroxylase- and vesicular monoamine transporter 2-positive neurons in the substantia nigra.
3 context sentences(design, population, supporting numbers)
Summary · context
Exendin-4 was tested in the 6-hydroxydopamine model of Parkinson's disease to investigate its possible functional effects in an animal model with neuronal loss.
Summary · context
After unilateral lesion and a 5-week stabilization period, the rats were treated for 3 weeks with exendin-4.
Summary · context
We investigated the effects of exendin-4 on neural stem/progenitor cells in the subventricular zone of the adult rodent brain and its functional effects in an animal model of Parkinson's disease.
Report a problemFND-1780322506
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with a Parkinson's disease model, exendin‑4 increased vesicular monoamine transporter 2-positive neurons in the substantia nigra.
In plain wordsIn rats with a Parkinson's disease model, exendin‑4 increased neurons positive for vesicular monoamine transporter 2.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseVesicular monoamine transporter 2-positive neurons
Study
ratn: not reported in source
6-hydroxydopamine model of Parkinson's disease
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 3 weeksAs given in this study (rat).
Source sentences
Summary
Histological analysis showed that exendin-4 significantly increased the number of both tyrosine hydroxylase- and vesicular monoamine transporter 2-positive neurons in the substantia nigra.
3 context sentences(design, population, supporting numbers)
Summary · context
Exendin-4 was tested in the 6-hydroxydopamine model of Parkinson's disease to investigate its possible functional effects in an animal model with neuronal loss.
Summary · context
After unilateral lesion and a 5-week stabilization period, the rats were treated for 3 weeks with exendin-4.
Summary · context
We investigated the effects of exendin-4 on neural stem/progenitor cells in the subventricular zone of the adult rodent brain and its functional effects in an animal model of Parkinson's disease.
Report a problemFND-1780322507
06LabIn vitro (cells)Efficacy outcome
In cultured rodent neural stem/progenitor cells, exendin‑4 increased cell number.
In plain wordsIn cells from rodent brains, exendin‑4 increased neural stem and precursor cell numbers.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseNeural stem/progenitor cell number
Study
rodentn: not reported in source
Cultured adult rodent subventricular neural stem/progenitor cells
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In vitro, exendin-4 increased the number of neural stem/progenitor cells, and the number of cells expressing the neuronal markers microtubule-associated protein 2, beta-III-tubulin, and neuron-specific enolase.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the effects of exendin-4 on neural stem/progenitor cells in the subventricular zone of the adult rodent brain and its functional effects in an animal model of Parkinson's disease.
Report a problemFND-1780322501
07LabIn vitro (cells)Efficacy outcome
In cultured rodent neural stem/progenitor cells, exendin‑4 increased cells expressing microtubule-associated protein 2, beta-III-tubulin, and neuron-specific enolase.
In plain wordsIn cells from rodent brains, exendin‑4 increased cells expressing neuronal markers.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseNeuronal marker-positive cells
Study
rodentn: not reported in source
Cultured adult rodent subventricular neural stem/progenitor cells
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
In vitro, exendin-4 increased the number of neural stem/progenitor cells, and the number of cells expressing the neuronal markers microtubule-associated protein 2, beta-III-tubulin, and neuron-specific enolase.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the effects of exendin-4 on neural stem/progenitor cells in the subventricular zone of the adult rodent brain and its functional effects in an animal model of Parkinson's disease.
Report a problemFND-1780322502

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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