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Study · In vitro (cells) · rat · 2007

8 results

Hexarelin suppresses cardiac fibroblast proliferation and collagen synthesis in rat.

Xu X, Pang J, Yin H, Li M, Hao W, Chen C, Cao JM

American journal of physiology. Heart and circulatory physiology31 Aug 2007Cited by 15 (Europe PMC)

PMID17766487 (opens in a new tab)DOI10.1152/ajpheart.00004.2007 (opens in a new tab)PepBankPUB-17766487
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In cultured rat cardiac fibroblasts, hexarelin inhibited angiotensin II-induced proliferation.

    In plain wordsIn rat heart cells in the lab, hexarelin reduced the growth of fibroblasts that angiotensin II had stimulated.

    Peptide
    Hexarelin
    Outcome
    DecreaseANG II-induced fibroblast proliferation
    Study

    ratn: not reported in source

    cultured cardiac fibroblasts from 8-day-old rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10(-7) mol/l · incubation in cell culture · 24 hAs given in this study (rat).

    Source sentences

    Summary
    It was found that incubation with 10(-7) mol/l hexarelin for 24 h 1) inhibited the ANG II-induced proliferation and collagen synthesis and the 5% FCS- and TGF-beta-induced increase of DNA synthesis in cardiac fibroblast and 2) reduced ANG II-induced upregulation of TGF-beta mRNA expression and activ…
    1 context sentence
    Summary · context
    In this report, cultured cardiac fibroblasts from 8-day-old rats were stimulated with ANG II or FCS to induce proliferation.
  2. 02LabIn vitro (cells)Efficacy outcome

    In cultured rat cardiac fibroblasts, hexarelin inhibited angiotensin II-induced collagen synthesis.

    In plain wordsIn rat heart cells in the lab, hexarelin reduced collagen production that angiotensin II had stimulated.

    Peptide
    Hexarelin
    Outcome
    DecreaseANG II-induced collagen synthesis
    Study

    ratn: not reported in source

    cultured cardiac fibroblasts from 8-day-old rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10(-7) mol/l · incubation in cell culture · 24 hAs given in this study (rat).

    Source sentences

    Summary
    It was found that incubation with 10(-7) mol/l hexarelin for 24 h 1) inhibited the ANG II-induced proliferation and collagen synthesis and the 5% FCS- and TGF-beta-induced increase of DNA synthesis in cardiac fibroblast and 2) reduced ANG II-induced upregulation of TGF-beta mRNA expression and activ…
    1 context sentence
    Summary · context
    In this report, cultured cardiac fibroblasts from 8-day-old rats were stimulated with ANG II or FCS to induce proliferation.
  3. 03LabIn vitro (cells)Efficacy outcome

    In cultured rat cardiac fibroblasts, hexarelin inhibited the increase of DNA synthesis induced by 5% FCS and by TGF-beta.

    In plain wordsIn rat heart cells in the lab, hexarelin reduced the rise in DNA synthesis caused by serum and by TGF-beta.

    Peptide
    Hexarelin
    Outcome
    DecreaseFCS- and TGF-beta-induced DNA synthesis
    Study

    ratn: not reported in source

    cultured cardiac fibroblasts from 8-day-old rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10(-7) mol/l · incubation in cell culture · 24 hAs given in this study (rat).

    Source sentences

    Summary
    It was found that incubation with 10(-7) mol/l hexarelin for 24 h 1) inhibited the ANG II-induced proliferation and collagen synthesis and the 5% FCS- and TGF-beta-induced increase of DNA synthesis in cardiac fibroblast and 2) reduced ANG II-induced upregulation of TGF-beta mRNA expression and activ…
    1 context sentence
    Summary · context
    In this report, cultured cardiac fibroblasts from 8-day-old rats were stimulated with ANG II or FCS to induce proliferation.
  4. 04LabIn vitro (cells)Mechanism

    In cultured rat cardiac fibroblasts, hexarelin reduced the angiotensin II-induced upregulation of TGF-beta mRNA.

    In plain wordsIn rat heart cells in the lab, hexarelin lowered the rise in TGF-beta mRNA that angiotensin II had caused.

    Peptide
    Hexarelin
    Outcome
    DecreaseANG II-induced TGF-beta mRNA expression
    Study

    ratn: not reported in source

    cultured cardiac fibroblasts from 8-day-old rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10(-7) mol/l · incubation in cell culture · 24 hAs given in this study (rat).

    Source sentences

    Summary
    It was found that incubation with 10(-7) mol/l hexarelin for 24 h 1) inhibited the ANG II-induced proliferation and collagen synthesis and the 5% FCS- and TGF-beta-induced increase of DNA synthesis in cardiac fibroblast and 2) reduced ANG II-induced upregulation of TGF-beta mRNA expression and activ…
    1 context sentence
    Summary · context
    In this report, cultured cardiac fibroblasts from 8-day-old rats were stimulated with ANG II or FCS to induce proliferation.
  5. 05LabIn vitro (cells)Mechanism

    In cultured rat cardiac fibroblasts, hexarelin reduced the angiotensin II-induced release of active TGF-beta1.

    In plain wordsIn rat heart cells in the lab, hexarelin lowered the release of active TGF-beta1 that angiotensin II had caused.

    Peptide
    Hexarelin
    Outcome
    DecreaseANG II-induced active TGF-beta1 release
    Study

    ratn: not reported in source

    cultured cardiac fibroblasts from 8-day-old rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10(-7) mol/l · incubation in cell culture · 24 hAs given in this study (rat).

    Source sentences

    Summary
    It was found that incubation with 10(-7) mol/l hexarelin for 24 h 1) inhibited the ANG II-induced proliferation and collagen synthesis and the 5% FCS- and TGF-beta-induced increase of DNA synthesis in cardiac fibroblast and 2) reduced ANG II-induced upregulation of TGF-beta mRNA expression and activ…
    1 context sentence
    Summary · context
    In this report, cultured cardiac fibroblasts from 8-day-old rats were stimulated with ANG II or FCS to induce proliferation.
  6. 06LabIn vitro (cells)Mechanism

    In cultured rat cardiac fibroblasts, hexarelin increased the cellular level of cAMP.

    In plain wordsIn rat heart cells in the lab, hexarelin raised the level of cAMP inside the cells.

    Peptide
    Hexarelin
    Outcome
    IncreaseCellular cAMP level
    Study

    ratn: not reported in source

    cultured cardiac fibroblasts from 8-day-old rats
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hexarelin increased the cellular level of cAMP in cardiac fibroblasts.
    1 context sentence
    Summary · context
    In this report, cultured cardiac fibroblasts from 8-day-old rats were stimulated with ANG II or FCS to induce proliferation.
  7. 07LabIn vitro (cells)Mechanism

    In cultured rat cardiac fibroblasts, the adenosine A2 receptor antagonist DMPX abolished the effect of hexarelin on DNA synthesis.

    In plain wordsIn rat heart cells in the lab, blocking the adenosine A2 receptor with DMPX removed the effect of hexarelin on DNA synthesis.

    Peptide
    Hexarelin
    Outcome
    Not applicableEffect of A2R antagonist DMPX on hexarelin effect on DNA synthesis
    Study

    ratn: not reported in source

    cultured cardiac fibroblasts from 8-day-old rats
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    DMPX (10(-8) mol/l) but not DPCPX abolished the effect of hexarelin on cardiac fibroblast DNA synthesis.
    1 context sentence
    Summary · context
    In this report, cultured cardiac fibroblasts from 8-day-old rats were stimulated with ANG II or FCS to induce proliferation.
  8. 08LabIn vitro (cells)Mechanism

    In cultured rat cardiac fibroblasts, the adenosine A1 receptor antagonist DPCPX did not abolish the effect of hexarelin on DNA synthesis.

    In plain wordsIn rat heart cells in the lab, blocking the adenosine A1 receptor with DPCPX did not remove the effect of hexarelin on DNA synthesis.

    Peptide
    Hexarelin
    Outcome
    No significant changeEffect of A1R antagonist DPCPX on hexarelin effect on DNA synthesis
    Study

    ratn: not reported in source

    cultured cardiac fibroblasts from 8-day-old rats
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    DMPX (10(-8) mol/l) but not DPCPX abolished the effect of hexarelin on cardiac fibroblast DNA synthesis.
    1 context sentence
    Summary · context
    In this report, cultured cardiac fibroblasts from 8-day-old rats were stimulated with ANG II or FCS to induce proliferation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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