17-Beta-estradiol directly regulates the expression of adrenergic receptors and kisspeptin/GPR54 system in GT1-7 GnRH neurons.

Jacobi JS, Martin C, Nava G, Jeziorski MC, Clapp C, Martínez de la Escalera G

Neuroendocrinology29 Aug 2007Cited by 44 (Europe PMC)

PMID17728535DOI10.1159/000107770PepBankPUB-17728535

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In GT1-7 GnRH neuron cells, kisspeptin‑10 at 1-10 nM increased GnRH release.
In plain wordsIn lab-grown GnRH neuron cells, kisspeptin‑10 raised GnRH release.
Peptide
Kisspeptin-10
Outcome
IncreaseGnRH release
Study
n: not reported in source
GT1-7 GnRH neuron cell line
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
1-10 nMAs given in this study.
Source sentences
Summary
Our data also showed that kisspeptin-10 (1-10 nM) can significantly stimulate GnRH release and GnRH mRNA expression in GT1-7 cells.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, we examined direct effects of 17beta-estradiol upon the expression of receptors for afferent signals at the level of the GnRH neuron, using immortalized GT1-7 cells.
Report a problemFND-1772853501
02LabIn vitro (cells)Activity measurement
In GT1-7 GnRH neuron cells, kisspeptin‑10 at 1-10 nM increased GnRH mRNA expression.
In plain wordsIn lab-grown GnRH neuron cells, kisspeptin‑10 raised GnRH gene activity.
Peptide
Kisspeptin-10
Outcome
IncreaseGnRH mRNA expression
Study
n: not reported in source
GT1-7 GnRH neuron cell line
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
1-10 nMAs given in this study.
Source sentences
Summary
Our data also showed that kisspeptin-10 (1-10 nM) can significantly stimulate GnRH release and GnRH mRNA expression in GT1-7 cells.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, we examined direct effects of 17beta-estradiol upon the expression of receptors for afferent signals at the level of the GnRH neuron, using immortalized GT1-7 cells.
Report a problemFND-1772853502

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

03LabEndogenous levelIn vitro (cells)Other
In GT1-7 GnRH neuron cells, 24 h of treatment with estradiol increased KiSS-1 (kisspeptin gene) mRNA expression.
In plain wordsIn lab-grown GnRH neuron cells, estradiol raised the activity of the gene for the body's own kisspeptin.
Peptide
Kisspeptin-10
Outcome
IncreaseKiSS-1 mRNA after 24 h of 17beta-estradiol
Study
n: not reported in source
GT1-7 GnRH neuron cell line
Outcome group
Endogenous peptide levels · Endocrine and hormones
Measurements
KiSS-1 mRNA fold change
8-fold
24 h estradiol
Source sentences
Summary
The expression of KiSS-1 and GPR54 mRNAs were also significantly increased (8- and 6-fold, respectively) after 24 h treatment of GT1-7 cells with estradiol.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, we examined direct effects of 17beta-estradiol upon the expression of receptors for afferent signals at the level of the GnRH neuron, using immortalized GT1-7 cells.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1772853503
04LabEndogenous levelIn vitro (cells)Other
GT1-7 GnRH neuron cells expressed mRNA for kisspeptin, as detected by RT-PCR.
In plain wordsIn lab-grown GnRH neuron cells, the gene for the body's own kisspeptin was active.
Peptide
Kisspeptin-10
Outcome
Not applicableKisspeptin mRNA expression in GT1-7 cells
Study
n: not reported in source
GT1-7 GnRH neuron cell line
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
showed for the first time that mRNAs for alpha(2)B-, beta(2)- and beta(3)-AR, for kisspeptin and its receptor GPR54 and for the novel estrogenic receptor GPR30 are expressed in GT1-7 cells
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, we examined direct effects of 17beta-estradiol upon the expression of receptors for afferent signals at the level of the GnRH neuron, using immortalized GT1-7 cells.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1772853504

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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