Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL14736, Pliva, Croatia) heals ileoileal anastomosis in the rat.

Vuksic T, Zoricic I, Brcic L, Sever M, Klicek R, Radic B, Cesarec V, Berkopic L, Keller N, Blagaic AB, Kokic N, Jelic I and 4 more

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Geber J, Anic T, Seiwerth S, Sikiric P

Surgery today27 Aug 2007Cited by 31 (Europe PMC)

PMID17713731DOI10.1007/s00595-006-3498-9PepBankPUB-17713731

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with ileoileal anastomosis, both higher doses of BPC‑157 improved all parameters of anastomotic wound healing.
In plain wordsIn rats with a joined section of intestine, the two higher doses of BPC‑157 improved all healing measures.
Peptide
BPC-157
Outcome
IncreaseOverall anastomotic wound healing parameters
Study
ratn: not reported in source
Ileoileal anastomosis
Comparator
Saline
Outcome group
Wound healing · Gastrointestinal
Studied dose
10 microg, 10 ng, 10 pg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Throughout the experiment, both higher doses of BPC 157 were shown to improve all parameters of anastomotic wound healing.
1 context sentence(design, population, supporting numbers)
Summary · context
BPC 157 (10 microg, 10 ng, 10 pg/kg i.p. (or saline [5 ml/kg]) was first administered after surgery, while it was last given 24 h before either assessment or sacrifice.
Report a problemFND-1771373101
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with ileoileal anastomosis, anastomoses without leakage had markedly higher volume and pressure values, rising continuously toward healthy values; the abstract does not state a BPC‑157 versus saline difference for this measure.
In plain wordsIn rats with a joined section of intestine, joins without leakage tolerated higher volume and pressure. The abstract does not link this to BPC‑157.
Peptide
BPC-157
Outcome
Direction not reportedLeak volume and pressure of the anastomosis
Study
ratn: not reported in source
Ileoileal anastomosis
Outcome group
Wound healing · Gastrointestinal
Studied dose
10 microg, 10 ng, 10 pg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Anastomosis without leakage induces markedly higher volume and pressure values, with a continuous increase toward healthy values.
2 context sentences(design, population, supporting numbers)
Summary · context
We assessed ileoileal anastomosis dehiscence macroscopically, histologically, and biomechanically (volume [ml] infused through a syringe-perfusion pump system (1 ml/10 s), and pressure [mmHg] to leak induction [catheter connected to a chamber and a monitor, at 10 cm proximal to anastomosis]), at 1,…
Summary · context
BPC 157 (10 microg, 10 ng, 10 pg/kg i.p. (or saline [5 ml/kg]) was first administered after surgery, while it was last given 24 h before either assessment or sacrifice.
Report a problemFND-1771373102
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with ileoileal anastomosis, edema was markedly attenuated from day 1 with BPC‑157.
In plain wordsIn rats with a joined section of intestine, swelling was clearly reduced from day 1 with BPC‑157.
Peptide
BPC-157
Outcome
DecreaseEdema
Study
ratn: not reported in source
Ileoileal anastomosis
Comparator
Saline
Outcome group
Wound healing · Gastrointestinal
Studied dose
10 microg, 10 ng, 10 pg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
From day 1, edema was markedly attenuated and the number of granulocytes decreased, while from days 4 or 5 necrosis decreased and granulation tissue, reticulin, and collagen formation substantially increased, thus resulting in increased epithelization.
1 context sentence(design, population, supporting numbers)
Summary · context
BPC 157 (10 microg, 10 ng, 10 pg/kg i.p. (or saline [5 ml/kg]) was first administered after surgery, while it was last given 24 h before either assessment or sacrifice.
Report a problemFND-1771373103
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with ileoileal anastomosis, the number of granulocytes decreased from day 1 with BPC‑157.
In plain wordsIn rats with a joined section of intestine, BPC‑157 lowered the number of granulocytes, a type of immune cell.
Peptide
BPC-157
Outcome
DecreaseGranulocyte count
Study
ratn: not reported in source
Ileoileal anastomosis
Comparator
Saline
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
10 microg, 10 ng, 10 pg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
From day 1, edema was markedly attenuated and the number of granulocytes decreased, while from days 4 or 5 necrosis decreased and granulation tissue, reticulin, and collagen formation substantially increased, thus resulting in increased epithelization.
1 context sentence(design, population, supporting numbers)
Summary · context
BPC 157 (10 microg, 10 ng, 10 pg/kg i.p. (or saline [5 ml/kg]) was first administered after surgery, while it was last given 24 h before either assessment or sacrifice.
Report a problemFND-1771373104
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with ileoileal anastomosis, necrosis decreased from days 4 or 5 with BPC‑157.
In plain wordsIn rats with a joined section of intestine, tissue death decreased from days 4 or 5 with BPC‑157.
Peptide
BPC-157
Outcome
DecreaseNecrosis
Study
ratn: not reported in source
Ileoileal anastomosis
Comparator
Saline
Outcome group
Wound healing · Gastrointestinal
Studied dose
10 microg, 10 ng, 10 pg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
From day 1, edema was markedly attenuated and the number of granulocytes decreased, while from days 4 or 5 necrosis decreased and granulation tissue, reticulin, and collagen formation substantially increased, thus resulting in increased epithelization.
1 context sentence(design, population, supporting numbers)
Summary · context
BPC 157 (10 microg, 10 ng, 10 pg/kg i.p. (or saline [5 ml/kg]) was first administered after surgery, while it was last given 24 h before either assessment or sacrifice.
Report a problemFND-1771373105
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with ileoileal anastomosis, granulation tissue formation substantially increased from days 4 or 5 with BPC‑157.
In plain wordsIn rats with a joined section of intestine, BPC‑157 substantially increased new repair tissue from days 4 or 5.
Peptide
BPC-157
Outcome
IncreaseGranulation tissue formation
Study
ratn: not reported in source
Ileoileal anastomosis
Comparator
Saline
Outcome group
Wound healing · Gastrointestinal
Studied dose
10 microg, 10 ng, 10 pg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
From day 1, edema was markedly attenuated and the number of granulocytes decreased, while from days 4 or 5 necrosis decreased and granulation tissue, reticulin, and collagen formation substantially increased, thus resulting in increased epithelization.
1 context sentence(design, population, supporting numbers)
Summary · context
BPC 157 (10 microg, 10 ng, 10 pg/kg i.p. (or saline [5 ml/kg]) was first administered after surgery, while it was last given 24 h before either assessment or sacrifice.
Report a problemFND-1771373106
07AnimalAnimal study (in vivo)Efficacy outcome
In rats with ileoileal anastomosis, reticulin formation substantially increased from days 4 or 5 with BPC‑157.
In plain wordsIn rats with a joined section of intestine, BPC‑157 substantially increased reticulin, a supporting fibre, from days 4 or 5.
Peptide
BPC-157
Outcome
IncreaseReticulin formation
Study
ratn: not reported in source
Ileoileal anastomosis
Comparator
Saline
Outcome group
Wound healing · Gastrointestinal
Studied dose
10 microg, 10 ng, 10 pg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
From day 1, edema was markedly attenuated and the number of granulocytes decreased, while from days 4 or 5 necrosis decreased and granulation tissue, reticulin, and collagen formation substantially increased, thus resulting in increased epithelization.
1 context sentence(design, population, supporting numbers)
Summary · context
BPC 157 (10 microg, 10 ng, 10 pg/kg i.p. (or saline [5 ml/kg]) was first administered after surgery, while it was last given 24 h before either assessment or sacrifice.
Report a problemFND-1771373107
08AnimalAnimal study (in vivo)Efficacy outcome
In rats with ileoileal anastomosis, collagen formation substantially increased from days 4 or 5 with BPC‑157.
In plain wordsIn rats with a joined section of intestine, BPC‑157 substantially increased collagen from days 4 or 5.
Peptide
BPC-157
Outcome
IncreaseCollagen formation
Study
ratn: not reported in source
Ileoileal anastomosis
Comparator
Saline
Outcome group
Wound healing · Gastrointestinal
Studied dose
10 microg, 10 ng, 10 pg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
From day 1, edema was markedly attenuated and the number of granulocytes decreased, while from days 4 or 5 necrosis decreased and granulation tissue, reticulin, and collagen formation substantially increased, thus resulting in increased epithelization.
1 context sentence(design, population, supporting numbers)
Summary · context
BPC 157 (10 microg, 10 ng, 10 pg/kg i.p. (or saline [5 ml/kg]) was first administered after surgery, while it was last given 24 h before either assessment or sacrifice.
Report a problemFND-1771373108
09AnimalAnimal study (in vivo)Efficacy outcome
In rats with ileoileal anastomosis, epithelization increased with BPC‑157.
In plain wordsIn rats with a joined section of intestine, BPC‑157 increased growth of the lining tissue over the wound.
Peptide
BPC-157
Outcome
IncreaseEpithelization
Study
ratn: not reported in source
Ileoileal anastomosis
Comparator
Saline
Outcome group
Wound healing · Gastrointestinal
Studied dose
10 microg, 10 ng, 10 pg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
From day 1, edema was markedly attenuated and the number of granulocytes decreased, while from days 4 or 5 necrosis decreased and granulation tissue, reticulin, and collagen formation substantially increased, thus resulting in increased epithelization.
1 context sentence(design, population, supporting numbers)
Summary · context
BPC 157 (10 microg, 10 ng, 10 pg/kg i.p. (or saline [5 ml/kg]) was first administered after surgery, while it was last given 24 h before either assessment or sacrifice.
Report a problemFND-1771373109
10AnimalAnimal study (in vivo)Safety outcome
In rats with ileoileal anastomosis, the formation of adhesions remained slight.
In plain wordsIn rats with a joined section of intestine, only slight adhesions formed.
Peptide
BPC-157
Outcome
Direction not reportedAdhesion formation
Study
ratn: not reported in source
Ileoileal anastomosis
Comparator
Saline
Outcome group
Adverse events · Gastrointestinal
Studied dose
10 microg, 10 ng, 10 pg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
The formation of adhesions remained slight, the blood vessels were filled with blood, and a mild intestinal passage obstruction was only temporarily observed.
1 context sentence(design, population, supporting numbers)
Summary · context
BPC 157 (10 microg, 10 ng, 10 pg/kg i.p. (or saline [5 ml/kg]) was first administered after surgery, while it was last given 24 h before either assessment or sacrifice.
Report a problemFND-1771373110
11AnimalAnimal study (in vivo)Safety outcome
In rats with ileoileal anastomosis, a mild intestinal passage obstruction was only temporarily observed.
In plain wordsIn rats with a joined section of intestine, a mild blockage of the intestine appeared only for a short time.
Peptide
BPC-157
Outcome
Direction not reportedIntestinal passage obstruction
Study
ratn: not reported in source
Ileoileal anastomosis
Comparator
Saline
Outcome group
Adverse events · Gastrointestinal
Studied dose
10 microg, 10 ng, 10 pg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
The formation of adhesions remained slight, the blood vessels were filled with blood, and a mild intestinal passage obstruction was only temporarily observed.
1 context sentence(design, population, supporting numbers)
Summary · context
BPC 157 (10 microg, 10 ng, 10 pg/kg i.p. (or saline [5 ml/kg]) was first administered after surgery, while it was last given 24 h before either assessment or sacrifice.
Report a problemFND-1771373111

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

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