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Study · Animal study (in vivo) · rat · 2007

7 results

[Comparative study of behavioral effects of cortexin and cerebrolysine upon intraventricular and intraperitoneal administration in rats].

Shabanov PD, Lebedev AA, Pavlenko VP, Ganapol'skiĭ VP

Eksperimental'naia i klinicheskaia farmakologiia1 May 2007

PMID17650626 (opens in a new tab)PepBankPUB-17650626
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In Wistar rats, cerebrolysin produced moderate psychostimulant action.

    In plain wordsIn rats, cerebrolysin produced moderate psychostimulant effects.

    Peptide
    Cerebrolysin
    Outcome
    IncreasePsychostimulant action
    Study

    ratn: not reported in source

    Wistar rats
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    1 mg to 10 mg and 100 mg intraventricularly; 1 mg/kg intraperitoneally · intraventricular and intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Both drugs produced a moderate psychostimulant action, cortexin being more effective as compared to cerebrolysin.
    2 context sentences
    Summary · context
    This effect was confirmed by all methods studied, including open field, elevated plus-maze, intruder-resident, and self-stimulation of the lateral hypothalamus.
    Summary · context
    The comparative central effects of polypeptide drugs cortexin and cerebrolysin were studied in Wistar rats after introduction into the cerebral ventriculi in a dose range from 1 mg to 10 mg and 100 mg and after intraperitoneal injections in a dose of 1 mg/kg.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In Wistar rats, cerebrolysin had weaker psychostimulant effects than cortexin.

    In plain wordsIn rats, cerebrolysin had weaker psychostimulant effects than cortexin.

    Peptide
    Cerebrolysin
    Outcome
    DecreasePsychostimulant action versus cortexin
    Study

    ratn: not reported in source

    Wistar rats
    Comparator
    Cortexin
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    1 mg to 10 mg and 100 mg intraventricularly; 1 mg/kg intraperitoneally · intraventricular and intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Both drugs produced a moderate psychostimulant action, cortexin being more effective as compared to cerebrolysin.
    1 context sentence
    Summary · context
    The comparative central effects of polypeptide drugs cortexin and cerebrolysin were studied in Wistar rats after introduction into the cerebral ventriculi in a dose range from 1 mg to 10 mg and 100 mg and after intraperitoneal injections in a dose of 1 mg/kg.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In Wistar rats, intraventricular cerebrolysin produced moderate anxiolytic action.

    In plain wordsIn rats, cerebrolysin injected into brain ventricles produced moderate anxiety-reducing effects.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseAnxiolytic action after intraventricular administration
    Study

    ratn: not reported in source

    Wistar rats
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    1 mg to 10 mg and 100 mg · intraventricularAs given in this study (rat).

    Source sentences

    Summary
    A difference between the intraventricular and intraperitoneal effects of drugs was that in the first case both drugs produced a moderate anxiolytic action, while in the second case an anxiogenic effect was registered.
    1 context sentence
    Summary · context
    The comparative central effects of polypeptide drugs cortexin and cerebrolysin were studied in Wistar rats after introduction into the cerebral ventriculi in a dose range from 1 mg to 10 mg and 100 mg and after intraperitoneal injections in a dose of 1 mg/kg.
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In Wistar rats, intraperitoneal cerebrolysin produced an anxiogenic effect.

    In plain wordsIn rats, cerebrolysin injected into the abdominal cavity produced an anxiety-increasing effect.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseAnxiogenic action after intraperitoneal administration
    Study

    ratn: not reported in source

    Wistar rats
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    1 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    A difference between the intraventricular and intraperitoneal effects of drugs was that in the first case both drugs produced a moderate anxiolytic action, while in the second case an anxiogenic effect was registered.
    1 context sentence
    Summary · context
    The comparative central effects of polypeptide drugs cortexin and cerebrolysin were studied in Wistar rats after introduction into the cerebral ventriculi in a dose range from 1 mg to 10 mg and 100 mg and after intraperitoneal injections in a dose of 1 mg/kg.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats, Cortexin produced greater psychostimulant effects than cerebrolysin.

    In plain wordsIn rats, Cortexin produced stronger stimulating effects than cerebrolysin.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreasePsychostimulant action
    Study

    ratn: not reported in source

    Wistar rats
    Comparator
    cerebrolysin
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Intraventricular: 1 mg to 10 mg and 100 mg. Intraperitoneal: 1 mg/kg. · intraventricular and intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Both drugs produced a moderate psychostimulant action, cortexin being more effective as compared to cerebrolysin.
    2 context sentences
    Summary · context
    This effect was confirmed by all methods studied, including open field, elevated plus-maze, intruder-resident, and self-stimulation of the lateral hypothalamus.
    Summary · context
    The comparative central effects of polypeptide drugs cortexin and cerebrolysin were studied in Wistar rats after introduction into the cerebral ventriculi in a dose range from 1 mg to 10 mg and 100 mg and after intraperitoneal injections in a dose of 1 mg/kg.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats, intraventricular Cortexin produced moderate anxiolytic action.

    In plain wordsIn rats, Cortexin injected into brain ventricles produced moderate anxiety-reducing effects.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseAnxiolytic action after intraventricular administration
    Study

    ratn: not reported in source

    Wistar rats
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    1 mg to 10 mg and 100 mg · intraventricularAs given in this study (rat).

    Source sentences

    Summary
    A difference between the intraventricular and intraperitoneal effects of drugs was that in the first case both drugs produced a moderate anxiolytic action, while in the second case an anxiogenic effect was registered.
    1 context sentence
    Summary · context
    The comparative central effects of polypeptide drugs cortexin and cerebrolysin were studied in Wistar rats after introduction into the cerebral ventriculi in a dose range from 1 mg to 10 mg and 100 mg and after intraperitoneal injections in a dose of 1 mg/kg.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats, intraperitoneal Cortexin produced an anxiogenic effect.

    In plain wordsIn rats, Cortexin injected into the abdominal cavity produced anxiety-increasing effects.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseAnxiogenic action after intraperitoneal administration
    Study

    ratn: not reported in source

    Wistar rats
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    1 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    A difference between the intraventricular and intraperitoneal effects of drugs was that in the first case both drugs produced a moderate anxiolytic action, while in the second case an anxiogenic effect was registered.
    1 context sentence
    Summary · context
    The comparative central effects of polypeptide drugs cortexin and cerebrolysin were studied in Wistar rats after introduction into the cerebral ventriculi in a dose range from 1 mg to 10 mg and 100 mg and after intraperitoneal injections in a dose of 1 mg/kg.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    14 Oct 2026, 05:02 UTC

    Study results updated

  3. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

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