Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression.

Tkalcević VI, Cuzić S, Brajsa K, Mildner B, Bokulić A, Situm K, Perović D, Glojnarić I, Parnham MJ

European journal of pharmacology16 Jun 2007Cited by 98 (Europe PMC)

PMID17628536DOI10.1016/j.ejphar.2007.05.072PepBankPUB-17628536

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with implanted sponges, PL 14736 stimulated granulation tissue with selectivity similar to PDGF-BB.
In plain wordsIn rats, PL 14736 stimulated new repair tissue about as well as the growth factor PDGF-BB.
Peptide
BPC-157
Outcome
IncreaseGranulation tissue stimulation in sponge granuloma
Study
ratn: not reported in source
Sponge implantation granulation tissue
Comparator
PDGF-BB
Outcome group
Wound healing · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
While PDGF-BB and PL 14736 had similar selectivity for stimulation of granulation tissue in both sponge granuloma and in healing wounds in db/db mice, PL 14736 was more active in stimulating early collagen organization.
1 context sentence(design, population, supporting numbers)
Summary · context
We have compared the mechanism of action of the potential wound healing agent, PL 14736 (G E P P P G K P A D D A G L V), with that of PDGF-BB on granulation tissue formation following sponge implantation in the normoglycemic rat and in healing full-thickness excisional wounds in db/db genetically diabetic mice.
Report a problemFND-1762853601
02AnimalAnimal study (in vivo)Efficacy outcome
In diabetic db/db mice, PL 14736 stimulated granulation tissue in healing wounds with selectivity similar to PDGF-BB.
In plain wordsIn diabetic mice, PL 14736 stimulated new repair tissue in wounds about as well as PDGF-BB.
Peptide
BPC-157
Outcome
IncreaseGranulation tissue stimulation in db/db mouse wounds
Study
mousen: not reported in source
Full-thickness excisional wounds in db/db diabetic mice
Comparator
PDGF-BB
Outcome group
Wound healing · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
While PDGF-BB and PL 14736 had similar selectivity for stimulation of granulation tissue in both sponge granuloma and in healing wounds in db/db mice, PL 14736 was more active in stimulating early collagen organization.
1 context sentence(design, population, supporting numbers)
Summary · context
We have compared the mechanism of action of the potential wound healing agent, PL 14736 (G E P P P G K P A D D A G L V), with that of PDGF-BB on granulation tissue formation following sponge implantation in the normoglycemic rat and in healing full-thickness excisional wounds in db/db genetically diabetic mice.
Report a problemFND-1762853602
03AnimalAnimal study (in vivo)Efficacy outcome
PL 14736 was more active than PDGF-BB in stimulating early collagen organization in rat sponge granuloma and mouse wounds.
In plain wordsIn rats and mice, PL 14736 stimulated early collagen organization more than PDGF-BB.
Peptide
BPC-157
Outcome
IncreaseEarly collagen organization
Study
rat; mousen: not reported in source
Sponge granuloma (rat) and db/db wounds (mouse)
Comparator
PDGF-BB
Outcome group
Wound healing · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
While PDGF-BB and PL 14736 had similar selectivity for stimulation of granulation tissue in both sponge granuloma and in healing wounds in db/db mice, PL 14736 was more active in stimulating early collagen organization.
1 context sentence(design, population, supporting numbers)
Summary · context
We have compared the mechanism of action of the potential wound healing agent, PL 14736 (G E P P P G K P A D D A G L V), with that of PDGF-BB on granulation tissue formation following sponge implantation in the normoglycemic rat and in healing full-thickness excisional wounds in db/db genetically diabetic mice.
Report a problemFND-1762853603
04LabIn vitro (cells)Mechanism
In non-differentiated Caco-2 cells, PL 14736 stimulated egr-1 expression more rapidly than PDGF-BB.
In plain wordsIn cells, PL 14736 switched on the egr-1 gene faster than PDGF-BB.
Peptide
BPC-157
Outcome
Increaseegr-1 expression
Study
humann: not reported in source
Non-differentiated Caco-2 cells
Comparator
PDGF-BB
Outcome group
Receptor activity and mechanism · Whole body
Studied dose
Dose not stated
Source sentences
Summary
It also stimulated expression of egr-1 and its repressor nerve growth factor 1-A binding protein-2 (nab2) in non-differentiated Caco-2 cells more rapidly than PDGF-BB.
1 context sentence(design, population, supporting numbers)
Summary · context
Expression of the immediate response gene, early growth response gene-1 (egr-1) was studied in Caco-2 cells in vitro.
Report a problemFND-1762853604
05LabIn vitro (cells)Mechanism
In non-differentiated Caco-2 cells, PL 14736 stimulated expression of nab2, the repressor of egr-1, more rapidly than PDGF-BB.
In plain wordsIn cells, PL 14736 switched on the nab2 gene faster than PDGF-BB.
Peptide
BPC-157
Outcome
Increasenab2 expression
Study
humann: not reported in source
Non-differentiated Caco-2 cells
Comparator
PDGF-BB
Outcome group
Receptor activity and mechanism · Whole body
Studied dose
Dose not stated
Source sentences
Summary
It also stimulated expression of egr-1 and its repressor nerve growth factor 1-A binding protein-2 (nab2) in non-differentiated Caco-2 cells more rapidly than PDGF-BB.
1 context sentence(design, population, supporting numbers)
Summary · context
Expression of the immediate response gene, early growth response gene-1 (egr-1) was studied in Caco-2 cells in vitro.
Report a problemFND-1762853605

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.