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Study · Not a test of the peptide alone · 2007

3 results

Structural preferences of neuroprotective S14G-humanin peptide analyzed by molecular modeling and circular dichroism.

Rojo-Domínguez A, Ramírez-Galicia G, Havel J, Gutiérrez-González LH

Protein and peptide letters1 Jan 2007Cited by 7 (Europe PMC)

PMID17627606 (opens in a new tab)DOI10.2174/092986607780989903 (opens in a new tab)PepBankPUB-17627606
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01LabNot a test of Humanin aloneIn vitro (cell-free)Other

    In circular dichroism of the S14G analog of humanin, spectra showed a small degree of ordering without or with low TFE, and a structured conformation formed at higher TFE.

    In plain wordsIn lab tests, the S14G humanin analog showed little order in water and formed a structured shape when more TFE was added.

    Peptide
    Humanin
    Outcome
    Not applicableCircular dichroism of S14G-humanin with TFE
    Study

    n: not reported in source

    Circular dichroism in water and in 2,2,2-trifluoroethanol
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    In the absence of TFE and at low TFE concentrations, CD spectra are indicative of a small degree of ordering in the peptide. On further increment of TFE concentration, changes occur that indicate the formation of a structured conformation.
    1 context sentence
    Summary · context
    Circular dichroism experimental studies of S14G-HN in aquaeous solution and in different 2,2,2-trifluoroethanol (TFE) concentrations were also performed.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02LabNot a test of Humanin aloneIn vitro (cell-free)Other

    Circular dichroism and simulation both indicated that the S14G analog has a lower helical propensity than wild type humanin and a higher conformational flexibility.

    In plain wordsIn lab tests and computer models, the S14G humanin analog was less helical and more flexible than wild type humanin.

    Peptide
    Humanin
    Outcome
    Not applicableHelical propensity of S14G-humanin versus wild type
    Study

    n: not reported in source

    Circular dichroism and molecular dynamics simulation
    Comparator
    Wild type humanin
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Both experimental and computational results indicate that S14G-HN has a reduced helical propensity, in contrast with wild type humanin, as well as a higher conformational flexibility.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03Computer modelNot a test of Humanin aloneIn silicoOther

    In molecular modeling of the S14G analog of humanin, residues 5 to 10 tended to form a beta strand and residues 13 to 17 tended to form a turn or irregular shape.

    In plain wordsIn computer models, the S14G humanin analog tended to form a strand in residues 5 to 10 and a turn in residues 13 to 17.

    Peptide
    Humanin
    Outcome
    Not applicablePredicted secondary structure of S14G-humanin
    Study

    n: not reported in source

    Structure prediction and molecular dynamics simulation
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    A beta strand tendency in residues 5 to 10 and a propensity to adopt turn or irregular conformation in residues 13 to 17 was found.
    1 context sentence
    Summary · context
    Side chain reconstruction, homology modeling and molecular dynamics (MD) simulations were performed on four different models.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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