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Study · Animal study (in vivo) · mouse · 2007

9 results

Thymosin beta4 is cardioprotective after myocardial infarction.

Srivastava D, Saxena A, Michael Dimaio J, Bock-Marquette I

Annals of the New York Academy of Sciences28 Jun 2007Cited by 37 (Europe PMC)

PMID17600280 (opens in a new tab)DOI10.1196/annals.1415.048 (opens in a new tab)PepBankPUB-17600280
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice after coronary artery ligation, thymosin beta‑4 treatment upregulated ILK in the heart.

    In plain wordsIn mice with a heart attack model, thymosin beta‑4 raised ILK in the heart.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseILK upregulation in the heart
    Study

    mousen: not reported in source

    coronary artery ligation
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After coronary artery ligation in mice, thymosin beta4 treatment resulted in upregulation of ILK and Akt activity in the heart, enhanced early myocyte survival, and improved cardiac function.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice after coronary artery ligation, thymosin beta‑4 treatment upregulated Akt activity in the heart.

    In plain wordsIn mice with a heart attack model, thymosin beta‑4 raised Akt activity in the heart.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseAkt activity in the heart
    Study

    mousen: not reported in source

    coronary artery ligation
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After coronary artery ligation in mice, thymosin beta4 treatment resulted in upregulation of ILK and Akt activity in the heart, enhanced early myocyte survival, and improved cardiac function.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice after coronary artery ligation, thymosin beta‑4 treatment enhanced early myocyte survival.

    In plain wordsIn mice with a heart attack model, thymosin beta‑4 improved early survival of heart muscle cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseEarly myocyte survival
    Study

    mousen: not reported in source

    coronary artery ligation
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After coronary artery ligation in mice, thymosin beta4 treatment resulted in upregulation of ILK and Akt activity in the heart, enhanced early myocyte survival, and improved cardiac function.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice after coronary artery ligation, thymosin beta‑4 treatment improved cardiac function.

    In plain wordsIn mice with a heart attack model, thymosin beta‑4 improved heart function.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCardiac function
    Study

    mousen: not reported in source

    coronary artery ligation
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After coronary artery ligation in mice, thymosin beta4 treatment resulted in upregulation of ILK and Akt activity in the heart, enhanced early myocyte survival, and improved cardiac function.
  5. 05LabIn vitro (cells)Efficacy outcome

    Thymosin beta‑4 promoted myocardial and endothelial cell migration in the embryonic heart.

    In plain wordsIn embryonic heart tissue, thymosin beta‑4 increased the movement of heart muscle and blood vessel cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseMyocardial and endothelial cell migration in embryonic heart
    Study

    n: not reported in source

    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We have found that the G-actin-sequestering peptide thymosin beta4 promotes myocardial and endothelial cell migration in the embryonic heart and retains this property in postnatal cardiomyocytes.
  6. 06LabIn vitro (cells)Efficacy outcome

    Thymosin beta‑4 retained its promotion of cell migration in postnatal cardiomyocytes.

    In plain wordsIn heart muscle cells from after birth, thymosin beta‑4 still increased cell movement.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCardiomyocyte migration in postnatal cardiomyocytes
    Study

    n: not reported in source

    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We have found that the G-actin-sequestering peptide thymosin beta4 promotes myocardial and endothelial cell migration in the embryonic heart and retains this property in postnatal cardiomyocytes.
  7. 07LabIn vitro (cells)Efficacy outcome

    Thymosin beta‑4 enhanced survival of embryonic and postnatal cardiomyocytes in culture.

    In plain wordsIn cells, thymosin beta‑4 improved the survival of heart muscle cells from embryos and after birth.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSurvival of cultured cardiomyocytes
    Study

    n: not reported in source

    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Survival of embryonic and postnatal cardiomyocytes in culture was also enhanced by thymosin beta4.
  8. 08LabIn vitro (cells)Mechanism

    In cardiomyocytes, thymosin beta‑4 formed a functional complex with PINCH and integrin-linked kinase.

    In plain wordsIn cells, thymosin beta‑4 formed a working complex with PINCH and integrin-linked kinase.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableComplex with PINCH and ILK
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    thymosin beta4 formed a functional complex with PINCH and integrin-linked kinase (ILK)
  9. 09LabIn vitro (cells)Mechanism

    In cardiomyocytes, the thymosin beta‑4 complex activated the survival kinase Akt/PKB, which was necessary for its effects.

    In plain wordsIn cells, thymosin beta‑4 switched on the survival enzyme Akt, which its effects on heart muscle cells needed.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseAkt/PKB activation in cardiomyocytes
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    resulting in activation of the survival kinase Akt/PKB, which was necessary for thymosin beta4's effects on cardiomyocytes.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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