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Study · Animal study (in vivo) · rat · 2007

3 results

Neuroprotection in focal cerebral ischemia owing to delayed treatment with melanocortins.

Giuliani D, Ottani A, Mioni C, Bazzani C, Galantucci M, Minutoli L, Bitto A, Zaffe D, Botticelli AR, Squadrito F, Guarini S

European journal of pharmacology5 Jun 2007Cited by 39 (Europe PMC)

PMID17588564 (opens in a new tab)DOI10.1016/j.ejphar.2007.05.025 (opens in a new tab)PepBankPUB-17588564
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with endothelin-1 induced focal cerebral ischemia, NDP-alpha-MSH reduced striatal damage when treatment began 3 h or 9 h after injury.

    In plain wordsIn rats with stroke-like brain injury, NDP-alpha-MSH reduced brain damage, even when treatment started hours later.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseStriatal damage
    Study

    ratn: not reported in source

    Focal cerebral ischemia induced by intrastriatal endothelin-1
    Comparator
    Vehicle-treated ischemic rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    340 microg/kg/day · intraperitoneal · 11 daysAs given in this study (rat).

    Source sentences

    Summary
    Treatment of ischemic rats with a nanomolar dose (340 microg/kg/day i.p. for 11 days, beginning 3 h or 9 h after endothelin-1 microinjection) of the melanocortin analog [Nle(4), D-Phe(7)]alpha-melanocyte-stimulating hormone (NDP-alpha-MSH) significantly reduced striatal damage, and improved subseque…
    1 context sentence
    Summary · context
    Here we aimed to investigate whether melanocortins are neuroprotective also in a rat model of focal cerebral ischemia induced by intrastriatal microinjection of endothelin-1.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with endothelin-1 induced focal cerebral ischemia, NDP-alpha-MSH improved functional recovery.

    In plain wordsIn rats with stroke-like brain injury, NDP-alpha-MSH improved recovery of function.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseFunctional recovery
    Study

    ratn: not reported in source

    Focal cerebral ischemia induced by intrastriatal endothelin-1
    Comparator
    Vehicle-treated ischemic rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    340 microg/kg/day · intraperitoneal · 11 daysAs given in this study (rat).

    Source sentences

    Summary
    Treatment of ischemic rats with a nanomolar dose (340 microg/kg/day i.p. for 11 days, beginning 3 h or 9 h after endothelin-1 microinjection) of the melanocortin analog [Nle(4), D-Phe(7)]alpha-melanocyte-stimulating hormone (NDP-alpha-MSH) significantly reduced striatal damage, and improved subseque…
    1 context sentence
    Summary · context
    Here we aimed to investigate whether melanocortins are neuroprotective also in a rat model of focal cerebral ischemia induced by intrastriatal microinjection of endothelin-1.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In ischemic rats, blockade of melanocortin MC4 receptors prevented the protective effect of NDP-alpha-MSH.

    In plain wordsIn rats with stroke-like brain injury, blocking the MC4 receptor removed the protective effect of NDP-alpha-MSH.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeNeuroprotection with MC4 receptor blockade
    Study

    ratn: not reported in source

    Focal cerebral ischemia induced by intrastriatal endothelin-1
    Comparator
    NDP-alpha-MSH without MC4 receptor blocker
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    340 microg/kg/day · intraperitoneal · 11 daysAs given in this study (rat).

    Source sentences

    Summary
    Pharmacological blockade of melanocortin MC(4) receptors prevented the protective effect of NDP-alpha-MSH.
    1 context sentence
    Summary · context
    Here we aimed to investigate whether melanocortins are neuroprotective also in a rat model of focal cerebral ischemia induced by intrastriatal microinjection of endothelin-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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