Thymosin beta4 upregulates the expression of hepatocyte growth factor and downregulates the expression of PDGF-beta receptor in human hepatic stellate cells.

Barnaeva E, Nadezhda A, Hannappel E, Sjogren MH, Rojkind M

Annals of the New York Academy of Sciences21 Jun 2007Cited by 26 (Europe PMC)

PMID17584975DOI10.1196/annals.1415.035PepBankPUB-17584975

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In human hepatic stellate cells, thymosin beta‑4 had no effect on alpha2(I) collagen mRNA expression.
In plain wordsIn human liver cells grown in a dish, thymosin beta‑4 did not change collagen mRNA.
Peptide
Thymosin beta-4 (human)
Outcome
No significant changealpha2(I) collagen mRNA expression
Study
humann: not reported in source
human hepatic stellate cells
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Tbeta(4) had no effect on the expression of alpha2 (I) collagen, tissue inhibitor of metalloproteinases-1, and matrix metalloproteinase-2 mRNAs.
1 context sentence(design, population, supporting numbers)
Summary · context
To this end we studied whether the administration of Tbeta(4) to HSCs could alter the expression of genes encoding for extracellular matrix components, as well as those required for differentiation of HSCs.
Report a problemFND-1758497501
02LabIn vitro (cells)Mechanism
In human hepatic stellate cells, thymosin beta‑4 had no effect on tissue inhibitor of metalloproteinases-1 mRNA expression.
In plain wordsIn human liver cells grown in a dish, thymosin beta‑4 did not change TIMP-1 mRNA.
Peptide
Thymosin beta-4 (human)
Outcome
No significant changeTIMP-1 mRNA expression
Study
humann: not reported in source
human hepatic stellate cells
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Tbeta(4) had no effect on the expression of alpha2 (I) collagen, tissue inhibitor of metalloproteinases-1, and matrix metalloproteinase-2 mRNAs.
1 context sentence(design, population, supporting numbers)
Summary · context
To this end we studied whether the administration of Tbeta(4) to HSCs could alter the expression of genes encoding for extracellular matrix components, as well as those required for differentiation of HSCs.
Report a problemFND-1758497502
03LabIn vitro (cells)Mechanism
In human hepatic stellate cells, thymosin beta‑4 had no effect on matrix metalloproteinase-2 mRNA expression.
In plain wordsIn human liver cells grown in a dish, thymosin beta‑4 did not change MMP-2 mRNA.
Peptide
Thymosin beta-4 (human)
Outcome
No significant changeMMP-2 mRNA expression
Study
humann: not reported in source
human hepatic stellate cells
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Tbeta(4) had no effect on the expression of alpha2 (I) collagen, tissue inhibitor of metalloproteinases-1, and matrix metalloproteinase-2 mRNAs.
1 context sentence(design, population, supporting numbers)
Summary · context
To this end we studied whether the administration of Tbeta(4) to HSCs could alter the expression of genes encoding for extracellular matrix components, as well as those required for differentiation of HSCs.
Report a problemFND-1758497503
04LabIn vitro (cells)Mechanism
In human hepatic stellate cells, thymosin beta‑4 upregulated hepatocyte growth factor mRNA expression.
In plain wordsIn human liver cells grown in a dish, thymosin beta‑4 raised hepatocyte growth factor mRNA.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseHGF mRNA expression
Study
humann: not reported in source
human hepatic stellate cells
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
it upregulated the expression of HGF and downregulated the expression of platelet-derived growth factor-beta receptor mRNAs in these cells.
1 context sentence(design, population, supporting numbers)
Summary · context
To this end we studied whether the administration of Tbeta(4) to HSCs could alter the expression of genes encoding for extracellular matrix components, as well as those required for differentiation of HSCs.
Report a problemFND-1758497504
05LabIn vitro (cells)Mechanism
In human hepatic stellate cells, thymosin beta‑4 downregulated platelet-derived growth factor-beta receptor mRNA expression.
In plain wordsIn human liver cells grown in a dish, thymosin beta‑4 lowered PDGF-beta receptor mRNA.
Peptide
Thymosin beta-4 (human)
Outcome
DecreasePDGF-beta receptor mRNA expression
Study
humann: not reported in source
human hepatic stellate cells
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
downregulated the expression of platelet-derived growth factor-beta receptor mRNAs in these cells.
1 context sentence(design, population, supporting numbers)
Summary · context
To this end we studied whether the administration of Tbeta(4) to HSCs could alter the expression of genes encoding for extracellular matrix components, as well as those required for differentiation of HSCs.
Report a problemFND-1758497505

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.